Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever

Abstract

ABSTRACT Aim: Familial Mediterranean Fever (FMF) is an autosomal recessive and self-limiting disease. FMF is characterized by recurrent episodes of fever, peritonitis, synovitis and pleuritis. Individuals with chronic illness tend to experience depression or anxiety. It has also been stated that affective temperaments are the basis of mood disorders. The aim of our study is to determine the frequency of anxiety and depression in FMF patients, to determine the dominant temperament type, and to compare the findings with the healthy control group. Method: 73 patients with FMF and 30 age- and gender-matched healthy individuals without any systemic disease were included in the study. The hospital anxiety and depression scale were used to measure depression and anxiety, and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego –Autoquestionnaire (TEMPS-A) temperament scale was used to determine the temperament type. Results: The number of cases diagnosed with anxiety was 33 (45.2%) in the patient group and 5 (16.6%) in the control group; The number of cases diagnosed with depression was 23 (31.5%) in the patient group and 2 (6.6%) in the control group, and both were also found to be statistically significantly higher. (P values p=0.02 and p=0.002, respectively) No statistically significant correlation was found between gender, age, disease duration, regular use of treatment, presence of gene mutation and attack type, and anxiety and depression scores. According to the TEMPS-A temperament scale, the percentage of patients diagnosed with depressive temperament (20.5%) was higher than the control group (3.3%), and the difference was statistically significant. (p=0.02). Conclusion: When the clinical picture in FMF patients becomes complicated with anxiety or depression or in the presence of a temperament predisposed to these conditions, there may be various problems in patients' compliance and response to treatment. FMF patients should be monitored for accompanying anxiety or depression during follow-up. Key Words: Anxiety, Depression, Familial Mediterranean Fever, Temperament

Keywords

• Anxiety
• Depression
• Familial Mediterranean Fever
• Temperament Characteristics

Project Number

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Ailesel Akdeniz Ateşi Olan Kişilerde Mizaç Özellikleri, Anksiyete ve Depresyon

Abstract

ÖZET Amaç: Ailesel Akdeniz Ateşi (AAA), tekrarlayan ateş, peritonit, plörit ve sinovit atakları ile karakterize, otozomal resesif geçişli, kendi kendini sınırlayan bir hastalıktır. Kronik hastalığa sahip olan bireyler depresyon veya anksiyete yaşama eğilimindedir. Ayrıca duygulanımla ilgili mizaçların duygudurum bozukluklarının temeli olduğu belirtilmiştir. Çalışmamızın amacı, AAA hastalarında anksiyete ve depresyon sıklığını belirlemek, baskın mizaç türünü belirlemek ve bulguları sağlıklı kontrol grubu ile karşılaştırmaktır. Yöntem: Çalışmaya 73 AAA tanılı hastayla birlikte herhangi sistemik hastalığa sahip olmayan yaş ve cinsiyeti uyumlu 30 sağlıklı birey alındı. Hastane anksiyete ve depresyon ölçeği depresyon ve anksiyeteyi ölçmek için ve Temperament Evaluation of Memphis, Pisa, Paris and San Diego –Autoquestionnaire (TEMPS-A) mizaç ölçeği mizaç tipini belirleme amaçlı kullanıldı. Bulgular: Hasta grubunda 33 (%45,2), kontrol grubunda 5 (%16,6) kişi anksiyete tanısı aldı ve aradaki fark istatistiksel olarak anlamlı yüksek bulundu (p=0,02). Hasta grubunda 23 (%31,5), kontrol grubunda 2 (%6,6) kişi depresyon tanısı aldı ve aradaki fark istatistiksel olarak anlamlı yüksek bulundu (p=0,002). Yaş, cinsiyet, hastalık süresi, tedaviyi düzenli kullanma, gen mutasyonu varlığı ve atak tipi ile anksiyete ve depresyon puanları arasında istatistiksel olarak anlamlı ilişki saptanmadı. TEMPS-A mizaç ölçeğine göre hastalardan depresif mizaç tanısı alanların yüzdesi ( %20,5) kontrol grubuna göre (%3,3) daha yüksekti ve aradaki fark istatistiksel olarak anlamlıydı (p=0,02). Sonuç: AAA hastalarındaki klinik tablo anksiyete veya depresyon ile komplike hale geldiğinde veya bu durumlara yatkın mizaç varlığında hastaların tedaviye uyumunda ve tedaviye yanıtında çeşitli sorunlar olabilmektedir. AAA hastaları, takip sırasında eşlik eden anksiyete veya depresyon açısından izlenmelidir. Anahtar Kelimeler: Ailesel Akdeniz Ateşi, Anksiyete, Depresyon, Mizaç

Keywords

• Ailesel Akdeniz Ateşi
• Mizaç Özellikleri
• Anksiyete
• Depresyon

Supporting Institution

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Project Number

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Thanks

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