Investigation of Glucose, Lipid, Chromium Level Changes in Gestational Diabetic and Nondiabetic Pregnants Compared with Healthy Groups

Yıl 2020, , 489 - 494, 31.12.2020

Adem Keskin , Emrullah Dorman

https://doi.org/10.34087/cbusbed.697511

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Aim: In this study, it is aimed to investigate the changes and interactions of these metabolic parameters in
pregnancy and gestational diabetes and by studying fasting blood sugar, total cholesterol, triglyceride and plasma
chromium parameters, in blood samples of pregnant women diagnosed with gestational diabetes, pregnant
women without diabetes and healthy women who are not pregnant in the same age group
Materials and Methods: This study included 50 pregnant women with gestational diabetes, 50 healthy pregnant
women without diabetes and 50 healthy non-pregnant women in the same age group. It was measured fasting
blood sugar, total cholesterol, triglyceride and plasma chromium concentrations in blood samples taken from the
patient and control groups
Results: Fasting blood sugar and plasma chromium levels of gestational diabetes group were significantly higher
than the other two groups (p <0.05). While the total cholesterol and triglyceride levels of the gestational diabetes
group were significantly higher than the control group (p <0.05), there was no significant difference from the non-diabetic group. Triglyceride and plasma chromium levels of non-diabetic pregnant group were higher than

the control group (p <0.05). Plasma chromium levels shows a positive correlation with Body mass index, total
cholesterol and triglyceride levels of all groups.
Conclusion: In this study, chromium levels in gestational diabetes mellitus patients were found to be
significantly higher than the other two groups. A positive correlation was found between plasma chromium and
Body mass index, triglyceride and total cholesterol levels. There are quite contradictory publications on all types
of diabetes and chromium. It seems to be on his role in diabetes, to include the level of chromium in the tissue of
future research.

Anahtar Kelimeler

Gestational Diabetes Mellitus, Glucose, Chrome, Total Cholesterol, Triglycerides

Gestasyonel Diyabetik ve Nondiyabetik Gebelerin Glukoz, Lipid, Krom Seviyelerinin Sağlıklı Gruplara Göre Değişimlerinin İncelenmesi

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Amaç: Bu çalışmada, gestasyonel diyabet tanısı almış ve diyabetli olmayan gebeler ile aynı yaş grubunda gebe olmayan sağlıklı kadın bireylerin Açlık Kan Şekeri (AKŞ), total kolesterol, trigliserit, ve plazma krom (Cr) parametreleri çalışılarak, bu metabolik parametrelerin, gebelik ile gestasyonel diyabetteki değişimleri ve birbirleri ile etkileşimlerinin incelenmesi amaçlanmıştır.
Gereç ve Yöntem: Bu çalışmaya, 50 adet gestasyonel diyabetli(GDM) gebe, 50 adet diyabetli olmayan sağlıklı gebe ile 50 adet aynı yaş grubunda olan gebe olmayan sağlıklı kadın birey dahil edilmiştir. Hasta ve kontrol grubundan alınan kan örneklerinde AKŞ, total kolesterol, trigliserit ve plazma Cr konsantrasyonları ölçülmüştür.
Bulgular: GDM’li grubun AKŞ ve plazma Cr düzeyleri, diğer iki gruptan anlamlı yüksek çıkmıştır(p<0.05). GDM’li grubun total kolesterol ve trigliserit düzeyleri kontrol grubuna göre anlamlı yüksek çıkarken(p<0.05), nondiyabetik gruptan anlamlı bir fark bulunmamıştır. Nondiyabetik gebe grubun trigliserit ve plazma Cr düzeyleri, kontrol grubuna göre yüksek bulunmuştur(p<0.05). Buna ek olarak tüm grupların plazma Cr düzeyleri; vücut kitle indeksi (VKİ), total kolesterol ve trigliserit düzeyleri ile pozitif korelasyon göstermektedir.
Sonuçlar: Bu çalışmada GDM’li hastalarda krom düzeyleri diğer iki gruba göre anlamlı olarak yüksek bulunmuştur. Plazma krom ile VKİ, trigliserit ve total kolesterol düzeyleri arasında pozitif korelasyon saptanmıştır. Krom ve diyabetin tüm türleri ile ilgili oldukça çelişkili yayınlar vardır, gelecekteki araştırmaların dokuda krom düzeyini de kapsayacak biçimde, diyabetteki rolü üzerine olacağı görülmektedir.

Anahtar Kelimeler

Gestasyonel Diyabetes Mellitus, Krom, Glukoz, Total Kolesterol, Trigliserit

Kaynakça

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