The Relationship Between Prognostic Nutritional Index and Carotid Artery Stenosis in Patients with Diagnosed Carotid Artery Disease

Abstract

Objective: To investigate the relationship between prognostic nutritional index (PNI) and carotid artery stenosis (CAS). Material and Methods: This retrospective observational study included patients undergoing carotid endarterectomy (CEA) and patients with non-critical CAS who received medical treatment. All data retrieved retrospectively from the hospital medical files. The values acquired from the patients during acceptance to the hospital were used in the calculation of PNI. Results: There were 82 patients (68.3 % male, mean age: 70.5±8.9 years) in surgical group, and 79 patients (72.2% male, mean age: 62.0±9.1 years) were recorded in medical group. We detected statistically difference in surgical group in terms of higher BUN (p <0.001), higher CRP (p = 0.037), lower lymphocyte (p <0.001), lower PNI (p = 0.008) and lower LDL-C (p = 0.045). For predicting development of carotid stenosis, in a cut-off level of 47.25 there were 73.4% sensitivity and 46.3% % specificity for PNI (Area under the curve (AUC): 0.619, 95% CI: 0.533-0.706, Log rank p = 0.009). Conclusion: Although we found that PNI was not an independent variable predicting CAS progression in our study, PNI values were statistically significantly lower in the surgical group. PNI may be a potential marker of CAS in patients. For this, large-scale studies involving healthy individuals are needed.

Keywords

• Carotid Artery Stenosis
• Prognostic Nutritional Index
• Atherosclerosis

Karotis Arter Hastalığı Tanısı Almış Hastalarda Prognostik Beslenme İndeksi ile Karotis Arter Darlığı Arasındaki İlişki

Abstract

Giriş ve Amaç: Prognostik beslenme indeksi (PNI) ile karotis arter stenozu (KAS) arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Bu retrospektif gözlemsel çalışma, karotis endarterektomi (CEA) geçiren hastaları ve tıbbi tedavi gören kritik olmayan KAS'lu hastaları içermektedir. Tüm veriler geriye dönük olarak hastanemizin tıbbi dosya kayıtlarından alındı. Hastaneye kabul sırasında hastalardan elde edilen değerler PNI hesaplamasında kullanıldı. Bulgular: Cerrahi grupta 82 hasta (% 68,3 erkek, ortalama yaş: 70,5 ± 8,9 yıl), medikal grupta 79 hasta (% 72,2 erkek, ortalama yaş: 62,0 ± 9,1 yıl) kaydedildi. Cerrahi grupta anlamlı düzeyde daha yüksek BUN (p <0,001), daha yüksek CRP (p = 0,037), daha düşük lenfosit sayısı (p <0,001), daha düşük PNI (p = 0,008) ve daha düşük LDL-C (p = 0,045) değerleri tespit ettik . Karotis stenoz gelişimini tahmin etmek için, 47,25'lik bir Cut-Off seviyesinde, PNI için% 73,4 duyarlılık ve% 46,3 özgüllük vardı (Eğri altındaki alan (EAA): 0,619, % 95 CI: 0,533-0,706, Log rank p = 0.009). Sonuç: Çalışmamızda PNI'nın KAS progresyonunu öngören bağımsız bir değişken olmadığını bulmamıza rağmen, PNI değerleri cerrahi grupta istatistiksel olarak anlamlı derecede düşüktü. PNI, hastalarda olası bir KAS belirteci olabilir. Bunun için sağlıklı bireyleri içeren geniş çaplı çalışmalara ihtiyaç vardır.

Keywords

• Karotis Arter Darlığı
• Prognostik Beslenme İndeksi
• Ateroskleroz

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