The Possible Relationship Between Plasma Homocysteine, Folate and Vitamin B12 Levels and Limbus Vertebra

Year 2018, Volume: 5 Issue: 3, 107 - 111, 28.09.2018

Yavuz Samanci Suat Erol Çelik

Abstract

Aim:
In spite of the fact that a few mechanisms have been proposed to take part in
the development of the limbus vertebra, the mechanism of LV is still vague. The
aim of this study was to determine the plasma levels of Hcy, folate and vitamin
B12 in a group of women with LV and to compare with those of age-and body mass
index-matched women in order to explore their possible contribution to the
pathophysiology of LV.

Material
and Methods: The current study was based on a
consecutive series of 171 premenopausal women who were diagnosed with LV and
190 age- and body mass index-matched premenopausal women without LV. Demographics,
dual-energy X-ray absorptiometry results, and plasma homocysteine, folate, and
vitamin B12 levels were assessed.

Results:
The anthropometric, clinical, densitometric and biochemical
features were not statistically different between two groups, except for Hcy
levels (p < 0.001). While Hcy levels were significantly negatively
correlated with age (r = -0.162, p = 0.034) in the LV group; there was no such
relation in the control group (r = 0.026, p = 0.721).

Discussion:
Premenopausal young women with LV have higher Hcy levels compared
to age- and body mass index-matched premenopausal women. High Hcy levels may
play role in the pathogenesis of LV formation.

Keywords

Folate, Homocysteine, Limbus Vertebra, Vitamin B12

Plazma Homosistein, Folat ve Vitamin B12 Düzeyleri ile Limbus Vertebra Arasındaki Olası İlişki

Abstract

Amaç: Limbus vertebra (LV) gelişiminde rol alan birkaç mekanizma önerilmiş olmasına rağmen, LV'nin mekanizması hala belirsizdir. Bu çalışmanın amacı, LV'lı bir grupta Hcy, folat ve vitamin B12'nin plazma düzeylerini belirlemek ve yaş ve beden kitle indeksi eşleştirilmiş kadınlarla karşılaştırmak ve LV patofizyolojisine olası katkılarını araştırmaktır.

Gereç ve Yöntemler: Bu çalışma, LV tanısı konan 171 premenopozal kadın ile LV'siz 190 yaş ve vücut kitle indeksi eşleştirilmiş premenopozal kadını içermektedir. Demografik, dual enerji X-ışını absorpsiyometri sonuçları ve plazma homosistein, folat ve vitamin B12 düzeyleri değerlendirilmiştir.

Bulgular: Antropometrik, klinik, dansitometrik ve biyokimyasal özellikler, Hcy düzeyleri dışında iki grup arasında istatistiksel olarak farklı değildi (p <0.001). Hcy düzeyleri LV grubunda yaşla birlikte anlamlı derecede negatif iken (r = -0.162, p = 0.034); kontrol grubunda böyle bir ilişki yoktu (r = 0.026, p = 0.721).

Tartışma: LV'li premenopozal genç kadınlar, yaş ve beden kitle indeksi eşleştirilmiş premenopozal kadınlara göre daha yüksek Hcy seviyelerine sahiptir. Yüksek Hcy seviyeleri, LV oluşumunun patogenezinde rol oynayabilir.

Keywords

Folat, Homosistein, Limbus Vertebra, B12 Vitamini

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