Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi

Sükeynet Aydın; Cahit Bilgin; Asuman Deveci Özkan; Ayşe Erdoğan Çakar; Mehmet Akdoğan; Mehtap Erdoğan

doi:10.34087/cbusbed.648181

Research Article

Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi

Year 2020, Volume: 7 Issue: 2, 167 - 172, 30.06.2020

Sükeynet Aydın Cahit Bilgin Asuman Deveci Özkan Ayşe Erdoğan Çakar Mehmet Akdoğan Mehtap Erdoğan

https://doi.org/10.34087/cbusbed.648181

Abstract

Amaç: Asimetrik
dimetilarjinin (ADMA) ve nitrik oksit (NO), etkilerini birlikte gösterirler, bu
moleküller arasındaki denge hava yolu tonusunun ve fonksiyonunun sıkı
düzenlenmesine katkıda bulunmaktadır. Çalışmamızda astım tedavisinin serum ADMA, NO, düzeylerine solunum
fonksiyon testlerindeki (SFT) değişimlerine, Total IgE, hemogram düzeylerindeki
değişiklikleri belirlemeyi amaçlanmıştır.

Gereç ve Yöntemler: Çalışmamızda astım tanısı konmuş 30 Erkek/Kadın hasta
(40-60 yaş) ve benzer yaş grubunda 24 Erkek/Kadın kontrol grubu kullanılmıştır.
Çalışmada tedavi öncesi ve sonrası hasta ve kontrol gruplarından serum ADMA,
NO, Total IgE düzeylerine
ticari kiti kullanılarak ELISA yöntemiyle ve hemogram düzeyleri ise otomatik kan sayım cihazında
belirlenmiştir.

Bulgular: Astımlı
hastaların tedavi öncesi ve tedavi sonrası ADMA ve NO düzeyleri kontrol grubu
ile arasında anlamlı fark bulunmuştur (p<0,001). Astımlı hastaların tedavi öncesi ve
tedavi sonrası grupların total IgE düzeyleri kontrol grubu ile arasında fark
istatistiksel olarak anlamlı bulunmuştur. (p<0,001). Astımlı hastaların
tedavi öncesi ve tedavi sonrası grupların %FVC ve % PEF₂₅_-_75%düzeyleri kontrol
grubu ile arasındaki fark, tedavi öncesi grubun %FVC, %PEF₂₅_-_75% düzeyleri tedavi
sonrası grup arasındaki fark istatistiksel olarak anlamlı bulunmuştur
(p<0,001).

Sonuç: Astım hastalarında
tedavinin hastalar üzerindeki etkileri bu çalışma ile belirlenmiş ve elde
edilen veriler tedavi sonrası astım hastalarında iyileşme gözlenen parametre
düzeylerinin astım hastalarında tedaviye yanıtın takibinin belirlenmesinde
kullanılabileceği ortaya konmuştur.

Keywords

Astım, ADMA, Nitrik Oksit, ELISA, Solunum Fonksiyon Testi

References

1. D'Amato, G, Holgate, S.T, Pawankar, R, Ledford, D.K, Cecchi, L, Al-Ahmad, M, Al-Enezi, F, Al-Muhsen, S, Ansotegui, I, Baena-Cagnani, C.E, Baker, D.J, Bayram, H, Bergmann, K.C, Boulet, L.P, Buters, J.T, D'Amato, M, Dorsano, S, Douwes, J, Finlay, S.E, Garrasi, D, Gómez, M, Haahtela, T, Halwani, R, Hassani, Y, Mahboub, B, Marks, G, Michelozzi, P, Montagni, M, Nunes C, Oh JJ, Popov T.A, Portnoy, J, Ridolo, E, Rosário, N, Rottem, M, Sánchez-Borges, M, Sibanda, E, Sienra-Monge, J.J, Vitale, C, Annesi-Maesano, I, Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders, A statement of the World Allergy Organization. World Allergy Organisation Journal, 2015, 8(1), 25.
2. Ramratnam, S.K, Bacharier, L.B, Guilbert, T.W, Severe Asthma in Children, Journal of Allergy and Clinical Immunology Practice, 2017, 5(4), 889-898.
3. Castillo, J.R, Peters, S.P, Busse, W.W, Asthma Exacerbations: Pathogenesis, Prevention, and Treatment. Journal of Allergy and Clinical Immunology Practice, 2017, 5(4), 918-927.
4. Tain, Y.L, Hsu C.N, Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA). Toxins (Basel), 2017, 9(3), 92.
5. Roos, A.B, Mori, M, Grönneberg, R, Österlund, C, Claesson, H.E, Wahlström, J, Grunewald, J, Eklund, A, Erjefält, J.S, Lundberg, J.O, Nord, M, Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS. PLoS One. 2014, 9(2):e90018.
6. Lau, E.M, Morgan, P.E, Belousova, E.G, Toelle, B.G, Ayer, J.G, Celermajer, D.S, Marks, G.B, Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study. European Respiratory Journal, 2013, 41(5), 1234-7.
7. Scott, J.A, North, M.L, Rafii, M, Huang, H, Pencharz, P, Subbarao, P, Belik, J, Grasemann, H. Asymmetric dimethylarginine is increased in asthma, American Journal of Respiratory and Critical Care Medicine, 2011, 184(7), 779-85.
8. Carraro, S, Giordano, G, Piacentini, G, Kantar, A, Moser, S, Cesca, L, Berardi, M, Di Gangi, I.M, Baraldi, E, Asymmetric dimethylarginine in exhaled breath condensate and serum of children with asthma, Chest, 2013 144(2), 405-410.
9. Holguin, F, Comhair, S.A, Hazen, S.L, Powers, R.W, Khatri, S.S, Bleecker, E.R, Busse, W.W, Calhoun, W.J, Castro, M, Fitzpatrick, A.M, Gaston, B, Israel, E, Jarjour, N.N, Moore, W.C, Peters, S.P, Teague, W.G, Chung, K.F, Erzurum, S.C, Wenzel, S.E, An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. American Journal of Respiratory and Critical Care Medicine, 2013, 187(2), 153-9.
10. Boulet, L.P, Gauvreau, G, Boulay M.E, O'Byrne, P, Cockcroft, D.W; Clinical Investigative Collaboration, Canadian Network of Centers of Excellence AllerGen, The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti-inflammatory therapies, Allergy, 2007, 62(10):1101-10.
11. Pizzichini, E, Pizzichini, M.M, Efthimiadis, A, Evans, S, Morris, M.M, Squillace, D, Gleich, G.J, Dolovich, J, Hargreave, F.E, Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. American Journal of Respiratory and Critical Care Medicine, 1996, 154(2 Pt 1), 308-17.
12. Global Strategy For Asthma Management and Prevention (GINA). 2017
13. Miller, M.R, Hankinson, J, Brusasco, V, Burgos, F, Casaburi, R, Coates, A, Crapo, R, Enright, P, Van der Grinten, C.P.M, Gustafsson, P, Jensen, R, , Johnson, D.C, MacIntyre, N, McKay, R, Navajas, D, Pedersen, O.F, Pellegrino, R, Viegi, G, Wanger, J, Standardization of spirometry, European Respiratory Journal, 2005, 26, 319-338.
14. Buğdaycı, G, Serin, E, Asimetrik Dimetilarginin (ADMA), Düzce Medical Journal, 2005, 2, 36-41.
15. Tülübaş, F, Gürel, A, Donma, M.M, Nalbantoğlu, B, Topçu, B, Mut, D.Z, Astım ve alerjik rinitli çocuklarda total IgE, C-reaktif protein ve kan sayım parametrelerinin değerlendirilmesi. Dicle Medical Journal, 2013, 40(1), 57-61.
16. Berry, A, Busse, W.W, Biomarkers in asthmatic patients: Has their time come to direct treatment? Journal of Allergy and Clinical Immunology, 2016, 137, 1317–1324.
17. Huang, F, Del-Río-Navarro, B.E, Torres-Alcántara, S, Pérez-Ontiveros, J.A, Ruiz-Bedolla, E, Saucedo-Ramírez, O.J, Villafaña, S, Sánchez Muñoz, F, Bravo, G, Hong, E, Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. Journal of Asthma, 2017, 54(2), 153-161.
18. Ashutosh K. Nitric oxide and asthma: a review, Current Opinion in Pulmonary Medicine, 2000, 6(1), 21-5.
19. Essat, M, Harnan, S, Gomersall, T, Tappenden, P, Wong, R, Pavord, I, Lawson, R, Everard, M.L, Fractional exhaled nitric oxide for the management of asthma in adults: a systematic review. European Respiratory Journal, 2016, 47(3), 751-68.
20. Reddel, H, Ware, S, Marks, G, Salome, C, Jenkins, C, Woolcock, A, Differences between asthma exacerbations and poor asthma control. Lancet 30, 353(9150), 364-9.
21. Tajti, G, Papp, C, Kardos, L, Keki, S, Pak, K, Magdolna Emma Szilasi ME, Positive correlation of airway resistance and serum asymmetric dimethylarginine (ADMA) in bronchial asthma patients lacking evidence for systemic inflammation, Allergy, Asthma & Clinical Immunology, 2018,14, 2.

Year 2020, Volume: 7 Issue: 2, 167 - 172, 30.06.2020

Sükeynet Aydın Cahit Bilgin Asuman Deveci Özkan Ayşe Erdoğan Çakar Mehmet Akdoğan Mehtap Erdoğan

https://doi.org/10.34087/cbusbed.648181

Abstract

References

1. D'Amato, G, Holgate, S.T, Pawankar, R, Ledford, D.K, Cecchi, L, Al-Ahmad, M, Al-Enezi, F, Al-Muhsen, S, Ansotegui, I, Baena-Cagnani, C.E, Baker, D.J, Bayram, H, Bergmann, K.C, Boulet, L.P, Buters, J.T, D'Amato, M, Dorsano, S, Douwes, J, Finlay, S.E, Garrasi, D, Gómez, M, Haahtela, T, Halwani, R, Hassani, Y, Mahboub, B, Marks, G, Michelozzi, P, Montagni, M, Nunes C, Oh JJ, Popov T.A, Portnoy, J, Ridolo, E, Rosário, N, Rottem, M, Sánchez-Borges, M, Sibanda, E, Sienra-Monge, J.J, Vitale, C, Annesi-Maesano, I, Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders, A statement of the World Allergy Organization. World Allergy Organisation Journal, 2015, 8(1), 25.
2. Ramratnam, S.K, Bacharier, L.B, Guilbert, T.W, Severe Asthma in Children, Journal of Allergy and Clinical Immunology Practice, 2017, 5(4), 889-898.
3. Castillo, J.R, Peters, S.P, Busse, W.W, Asthma Exacerbations: Pathogenesis, Prevention, and Treatment. Journal of Allergy and Clinical Immunology Practice, 2017, 5(4), 918-927.
4. Tain, Y.L, Hsu C.N, Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA). Toxins (Basel), 2017, 9(3), 92.
5. Roos, A.B, Mori, M, Grönneberg, R, Österlund, C, Claesson, H.E, Wahlström, J, Grunewald, J, Eklund, A, Erjefält, J.S, Lundberg, J.O, Nord, M, Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS. PLoS One. 2014, 9(2):e90018.
6. Lau, E.M, Morgan, P.E, Belousova, E.G, Toelle, B.G, Ayer, J.G, Celermajer, D.S, Marks, G.B, Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study. European Respiratory Journal, 2013, 41(5), 1234-7.
7. Scott, J.A, North, M.L, Rafii, M, Huang, H, Pencharz, P, Subbarao, P, Belik, J, Grasemann, H. Asymmetric dimethylarginine is increased in asthma, American Journal of Respiratory and Critical Care Medicine, 2011, 184(7), 779-85.
8. Carraro, S, Giordano, G, Piacentini, G, Kantar, A, Moser, S, Cesca, L, Berardi, M, Di Gangi, I.M, Baraldi, E, Asymmetric dimethylarginine in exhaled breath condensate and serum of children with asthma, Chest, 2013 144(2), 405-410.
9. Holguin, F, Comhair, S.A, Hazen, S.L, Powers, R.W, Khatri, S.S, Bleecker, E.R, Busse, W.W, Calhoun, W.J, Castro, M, Fitzpatrick, A.M, Gaston, B, Israel, E, Jarjour, N.N, Moore, W.C, Peters, S.P, Teague, W.G, Chung, K.F, Erzurum, S.C, Wenzel, S.E, An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. American Journal of Respiratory and Critical Care Medicine, 2013, 187(2), 153-9.
10. Boulet, L.P, Gauvreau, G, Boulay M.E, O'Byrne, P, Cockcroft, D.W; Clinical Investigative Collaboration, Canadian Network of Centers of Excellence AllerGen, The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti-inflammatory therapies, Allergy, 2007, 62(10):1101-10.
11. Pizzichini, E, Pizzichini, M.M, Efthimiadis, A, Evans, S, Morris, M.M, Squillace, D, Gleich, G.J, Dolovich, J, Hargreave, F.E, Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. American Journal of Respiratory and Critical Care Medicine, 1996, 154(2 Pt 1), 308-17.
12. Global Strategy For Asthma Management and Prevention (GINA). 2017
13. Miller, M.R, Hankinson, J, Brusasco, V, Burgos, F, Casaburi, R, Coates, A, Crapo, R, Enright, P, Van der Grinten, C.P.M, Gustafsson, P, Jensen, R, , Johnson, D.C, MacIntyre, N, McKay, R, Navajas, D, Pedersen, O.F, Pellegrino, R, Viegi, G, Wanger, J, Standardization of spirometry, European Respiratory Journal, 2005, 26, 319-338.
14. Buğdaycı, G, Serin, E, Asimetrik Dimetilarginin (ADMA), Düzce Medical Journal, 2005, 2, 36-41.
15. Tülübaş, F, Gürel, A, Donma, M.M, Nalbantoğlu, B, Topçu, B, Mut, D.Z, Astım ve alerjik rinitli çocuklarda total IgE, C-reaktif protein ve kan sayım parametrelerinin değerlendirilmesi. Dicle Medical Journal, 2013, 40(1), 57-61.
16. Berry, A, Busse, W.W, Biomarkers in asthmatic patients: Has their time come to direct treatment? Journal of Allergy and Clinical Immunology, 2016, 137, 1317–1324.
17. Huang, F, Del-Río-Navarro, B.E, Torres-Alcántara, S, Pérez-Ontiveros, J.A, Ruiz-Bedolla, E, Saucedo-Ramírez, O.J, Villafaña, S, Sánchez Muñoz, F, Bravo, G, Hong, E, Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. Journal of Asthma, 2017, 54(2), 153-161.
18. Ashutosh K. Nitric oxide and asthma: a review, Current Opinion in Pulmonary Medicine, 2000, 6(1), 21-5.
19. Essat, M, Harnan, S, Gomersall, T, Tappenden, P, Wong, R, Pavord, I, Lawson, R, Everard, M.L, Fractional exhaled nitric oxide for the management of asthma in adults: a systematic review. European Respiratory Journal, 2016, 47(3), 751-68.
20. Reddel, H, Ware, S, Marks, G, Salome, C, Jenkins, C, Woolcock, A, Differences between asthma exacerbations and poor asthma control. Lancet 30, 353(9150), 364-9.
21. Tajti, G, Papp, C, Kardos, L, Keki, S, Pak, K, Magdolna Emma Szilasi ME, Positive correlation of airway resistance and serum asymmetric dimethylarginine (ADMA) in bronchial asthma patients lacking evidence for systemic inflammation, Allergy, Asthma & Clinical Immunology, 2018,14, 2.

There are 21 citations in total.

Details

Primary Language	Turkish
Subjects	Biochemistry and Cell Biology (Other)
Journal Section	Araştırma Makalesi
Authors	Sükeynet Aydın This is me 0000-0001-8129-5274 Cahit Bilgin 0000-0001-8129-5274 Asuman Deveci Özkan 0000-0002-3248-4279 Ayşe Erdoğan Çakar 0000-0002-5568-3959 Mehmet Akdoğan 0000-0003-2089-0082 Mehtap Erdoğan 0000-0002-9294-4919
Publication Date	June 30, 2020
Published in Issue	Year 2020 Volume: 7 Issue: 2

Cite

APA	Aydın, S., Bilgin, C., Deveci Özkan, A., Erdoğan Çakar, A., et al. (2020). Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 7(2), 167-172. https://doi.org/10.34087/cbusbed.648181
AMA	Aydın S, Bilgin C, Deveci Özkan A, Erdoğan Çakar A, Akdoğan M, Erdoğan M. Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. June 2020;7(2):167-172. doi:10.34087/cbusbed.648181
Chicago	Aydın, Sükeynet, Cahit Bilgin, Asuman Deveci Özkan, Ayşe Erdoğan Çakar, Mehmet Akdoğan, and Mehtap Erdoğan. “Astım Hastalarında Tedavinin Nitrik Oksit Ve Asimetrik Dimetil Arginin Düzeylerine Etkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 7, no. 2 (June 2020): 167-72. https://doi.org/10.34087/cbusbed.648181.
EndNote	Aydın S, Bilgin C, Deveci Özkan A, Erdoğan Çakar A, Akdoğan M, Erdoğan M (June 1, 2020) Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 7 2 167–172.
IEEE	S. Aydın, C. Bilgin, A. Deveci Özkan, A. Erdoğan Çakar, M. Akdoğan, and M. Erdoğan, “Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi”, CBU-SBED: Celal Bayar University-Health Sciences Institute Journal, vol. 7, no. 2, pp. 167–172, 2020, doi: 10.34087/cbusbed.648181.
ISNAD	Aydın, Sükeynet et al. “Astım Hastalarında Tedavinin Nitrik Oksit Ve Asimetrik Dimetil Arginin Düzeylerine Etkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 7/2 (June 2020), 167-172. https://doi.org/10.34087/cbusbed.648181.
JAMA	Aydın S, Bilgin C, Deveci Özkan A, Erdoğan Çakar A, Akdoğan M, Erdoğan M. Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2020;7:167–172.
MLA	Aydın, Sükeynet et al. “Astım Hastalarında Tedavinin Nitrik Oksit Ve Asimetrik Dimetil Arginin Düzeylerine Etkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 7, no. 2, 2020, pp. 167-72, doi:10.34087/cbusbed.648181.
Vancouver	Aydın S, Bilgin C, Deveci Özkan A, Erdoğan Çakar A, Akdoğan M, Erdoğan M. Astım Hastalarında Tedavinin Nitrik Oksit ve Asimetrik Dimetil Arginin Düzeylerine Etkisi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2020;7(2):167-72.

Download Cover Image

Article Files

Full Text