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Ailesel Akdeniz Ateşi

Year 2020, Volume: 7 Issue: 3, 413 - 417, 30.09.2020

Esra Nagehan Akyol Onder Pelin Ertan

https://doi.org/10.34087/cbusbed.696594
Cited By: 2

Abstract

Ailesel Akdeniz Ateşi (AAA) tekrarlayan ateş ve ateşe eşlik eden seröz zarların inflamasyonu ile karakterli otozomal resesif geçiş gösteren en sık otoinflamatuar hastalıktır. Özellikle Yahudiler, Araplar, Türkler ve Ermeniler’de sık olarak görülür. Kendi kendini sınırlayan ateş, karın ağrısı, göğüs ağrısı, eklem ağrısı ve şişliği, erizipel benzeri eritem atakları en sık belirti ve bulgulardır. Henoch Schönlein Purpura ve Poliarteritis Nodosa ile AAA birlikteliği sıktır. Tanı koymak amacı ile kullanılan spesifik bir test olmayıp hastalığın tanısı klinik ile konulur. Atak sırasında bakılan akut faz reaktanlarında artış ve atak dışı dönemde bunların normale dönmesi tanıyı destekler. AAA ayırıcı tanısında, diğer periyodik ateş sendromları ve diğer romatolojik hastalıklar, enfeksiyonlar, akut batın sendromları, maligniteler, porfiria gibi diğer hastalıklar göz önünde bulundurulmalıdır. 1972 yılından beri hastalığın tedavisinde etkin ilaç olarak kolşisin kullanılmaktadır. Kronik inflamasyona ikincil olarak gelişen AA (sekonder) amiloidoz, AAA’nın en ciddi komplikasyonudur. Kolşisin tedavisi atakların süre, sıklık ve şiddetini azalttığı gibi amiloidoz riskini de önler. Son yıllarda kolşisin tedavisini tolere edemeyen veya ilaca yanıt alınamayan hastalarda interlökin-1 antagonistlerinin kullanımı ile başarılı sonuçlar elde edilmiştir.

Keywords

Ailesel Akdeniz Ateşi amiloidoz kolşisin

References

  • Referans1. Ben-Chetrit, E, Levy, M. Familial Mediterranean fever. Lancet, 1998;351:659-64.
  • Referans2. Janeway, T.C, Mosenthal, H, Unusual paroxysmal syndrome, probably allied to recurrent vomiting, with a study of nitrogen metabolism. Trans Assoc Am Physicians, 1908; 23: 504518.
  • Referans3. Siegal, S, Benign paroxysmal peritonitis. Ann Intern Med, 1945; 23: 1-21.
  • Referans4. Marmaralı, A, Garip bir karın ağrısı sendromu. Türk Tıp Cem Mec, No:12, 1946.
  • Referans5. Mamou, H, Cattan, R, La maladie periodique. Sem Hop Paris 1952;1062-70.
  • Referans6. Heller, H, Sohar, E, Sherf, L, Familial Mediterranean fever. Arch Intern Med, 1958;102(1):50-71.
  • Referans7. Özkan, E, Okur, Ö, Ekmekçi, A, Özcan, R, Tag, T, A new approach to the treatment of periodic fever. Med Bull Istanbul, 1972; 5: 44-49.
  • Referans8. Goldfinger, S.E, Colchicine for Familial Mediterranean Fever. N Engl J Med, 1972; 287: 1302.
  • Referans9. Fonnesu, C, Cerquaglia, C, Giovinale, M, et al. Familial Mediterranean Fever: A review for clinical management. Joint Bone Spine, 2009; 76: 227-233.
  • Referans10. Onen, F, Familial Mediterranean fever. Rheumatol Int, 2006; 26(6): 489–96.
  • Referans11. Ben-Chetrit, E, Touitou, I, Familial Mediterranean Fever in the World. Arthritis&Rheumatism, 2009;61:1447-53.
  • Referans12. Lidar, M, Livneh, A, Familial Mediterranean Fever: clinical, molecular and advancements. The Journal of Medicine, 2007; 65 (9): 318-324.
  • Referans13. Turkısh FMF Study Group. Familial Mediterranean Fever in Turkey. Results of a Nationwide Multicenter Study. Medicine, 2005; 84: 1-11.
  • Referans14. Baskın, E, Saatçi, Ü, Familial Mediterranean Fever. Current Rheumatology Reviews, 2006; 2:101-108.
  • Referans15. Kasapçopur, Ö, Arısoy, N, Ailesel Akdeniz Ateşi ve diğer otoenflamatuar hastalıklar. Türk Pediatri Arşivi, 2006; 41; 9-17.
  • Referans16. The international FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause FMF. Cell, 1997; 90:797-807.
  • Referans17. French FMF Consortium. A candidate gene for familial mediterranean fever. Nature Genetics, 1997; 17: 25-31.
  • Referans18. Soylemezoglu, O, Kandur, Y, Gonen, S, Düzova, A, Ozcakar, Z.B, Fidan, K, et al. Familial Mediterrenean fever gene mutation frequencies in a sample Turkish population. Clin Exp Rheumatol, 2016:102(6):97-100.
  • Referans19. Touitou I. Inheritance of autoinflammatory diseases: shifting pradigms and nomenclature. J Med Genet, 2013;50(6):349-59.
  • Referans20. Ozturk, C, Halıcıoglu, O, Coker, I, Gulez, N, Sutçuoglu, S, Karaca, N, et al. Association of clinical and genetical features in FMF with focus on MEFV strip assay sensitivity in 452 children from western Anatolia, Turkey. Clin Rheumatol, 2012;31:493-501.
  • Referans21. Arıcı, Z.S, Bilginer, Y, Özen, S, Ailesel Akdeniz Ateşi: Epidemiyoloji ve Genetik, Türkiye Klinikleri J Rheumatol-Special Topics, 2017;10(1):1-7.
  • Referans22. Manukyan, G, Rustam, A, Update on Pyrifunctions and mechanisms of Familial Mediterrenean Fever. Front. Microbiol, 2016;7:456.
  • Referans23. Wang, D.Q.H, Bonfrate, L, de Bari, O, Wang, T.Y, Portincasa, P, Familial Mediterranean fever: From pathogenesis to treatment. J Genet Syndr Gene Ther, 2014;5:248.
  • Referans24. Tamir, N, Langevitz, P, Zemer, D, Pras, E, Shinar, Y, Padeh, S, et al. Late-onset familial Mediterranean fever (FMF): a subset with distinct clinical, demographic, and molecular genetic characteristics. Am J Med Genet 1999;87(1):30-5.
  • Referans25. Özdel, S, Özçakar, Z.B, Şahin-Kunt, S, Elhan, A.E,Yalçınkaya, F. Late-onset disease is associated With a mild phenotype in children with familial Mediterranean fever. Clin Rheumatol, 2016 Jul;35(7):1837-40.
  • Referans26. Aydın, F, Özçakar, Z.B, Yalçınkaya, F, Çocuklarda Ailesel Akdeniz Ateşi Tanı ve Tedavisi, Türkiye Klinikleri J Rheumatol-Special Topics, 2017;10(1):46-54.
  • Referans27. Saatçi, Ü, Özen, S, Özdemir, S, Bakkaloğlu, A, Beşbaş, N, Topaloğlu, R, Arslan, Ş, Familial mediterranean fever in children: report of a large series and discussion of the risk and prognostic factors of amyloidosis. Eur J Pediatr, 1997; 156: 619-23.
  • Referans28. Sarı, I, Birlik, M, Kasifoğlu, T, Familial Mediterraneanfever: An updated review. Eur J Rheumatol, 2014;1(1):21-33.
  • Referans29. Tunca, M, Akar, S, Onen, F, Ozdogan, H, Kasapcopur, O, Yalcinkaya, F, Et al; Turkish FMF Study Group. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore), 2005; 84(1):1-11.
  • Referans30. Mor, A, Gal, R, Livneh, A, Abdominal and digestive system associations of familial mediterranean fever. Am J Gastroenterol, 2003; 98:2594-604.
  • Referans31. Lidar, M, Pras, M, Langevitz, P, Livneh A, Thoracic and Lung Involvement in Familial Mediaterranean Fever. Clin Chest Med, 2002; 23: 505-511.
  • Referans32. Langevitz, P, Zemer, D, Livneh, A, Shemer, J, Pras, M. Protracted febrile myalgia in patients with Familial Mediterranean Fever. J Rheumatol, 1994; 21: 1708-09.
  • Referans33. Yalcinkaya, F, Tekin, M, Çakar, N, Akar, E, Akar, N, Tümer,N, Familial Mediterrenean fever and systemic amyloidosis in untreated Turkish patients. Q J Med, 2000;93:681-4.
  • Referans34. Yalçinkaya, F, Tümer, N, Glomerular lesions other than amyloidosis in patients with familial Mediterranean fever. Nephrol Dial Transplant, 1999;14(1):21-3.
  • Referans35. Padeh, S, Periodic fever syndromes. Pediatr Clin N Am, 2005; 52:577-609.
  • Referans36. Sohar, E, Gafni,, J, Pras M, Heller, H, FMF: A survey of 470 cases and review of the literature. Am J Med, 1967;43:227-5.
  • Referans37. Livneh, A, Langevitz, P, Zemer, D et al. Criteria for the diagnosis of Familial mediterranean Fever. Arthritis-Rheumatism 1997; 40: 1879-85.
  • Referans38. Yalçınkaya, F, Ozen, S, Ozcakar, Z.B¸ Aktay, N, Çakar, N, Düzova, A, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology, 2009;48: 395-98.
  • Referans39. Kondi, A, Hentgen, V, Piram, M, Letierce, A, Guillaume-Czitrom, S, Koné-Paut, Validation of the new paediatric criteria for the diagnosis of familial Mediterranean fever: data from a mixed population of 100 children from the French reference centre for auto-inflammatory disorders. Rheumatology (Oxford), 2010;49:2200-03.
  • Referans40. Slobodnick, A, Shah, B, Pillinger, M.H, Krasnokutsky, S, Colchicine: Old and New. The American Journal of Medicine, 2015;128:46170.
  • Referans41. Van der Hilst, J.C.H, Moutschen, M, Messiaen, P1, Lauwerys, B.R, Vanderschueren, S, Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature. Biologics, 2016;4(10):75-80.
  • Referans42. Mitroulis, I, Papadopoulos, VP, Konstantinidis, T, Ritis, K, Anakinra suppresses familial Mediterranean fever crises in a colchicine-resistant patient. The Journal of Medicine, 2008; 66: 489-91.

Year 2020, Volume: 7 Issue: 3, 413 - 417, 30.09.2020

Esra Nagehan Akyol Onder Pelin Ertan

https://doi.org/10.34087/cbusbed.696594
Cited By: 2

Abstract

References

  • Referans1. Ben-Chetrit, E, Levy, M. Familial Mediterranean fever. Lancet, 1998;351:659-64.
  • Referans2. Janeway, T.C, Mosenthal, H, Unusual paroxysmal syndrome, probably allied to recurrent vomiting, with a study of nitrogen metabolism. Trans Assoc Am Physicians, 1908; 23: 504518.
  • Referans3. Siegal, S, Benign paroxysmal peritonitis. Ann Intern Med, 1945; 23: 1-21.
  • Referans4. Marmaralı, A, Garip bir karın ağrısı sendromu. Türk Tıp Cem Mec, No:12, 1946.
  • Referans5. Mamou, H, Cattan, R, La maladie periodique. Sem Hop Paris 1952;1062-70.
  • Referans6. Heller, H, Sohar, E, Sherf, L, Familial Mediterranean fever. Arch Intern Med, 1958;102(1):50-71.
  • Referans7. Özkan, E, Okur, Ö, Ekmekçi, A, Özcan, R, Tag, T, A new approach to the treatment of periodic fever. Med Bull Istanbul, 1972; 5: 44-49.
  • Referans8. Goldfinger, S.E, Colchicine for Familial Mediterranean Fever. N Engl J Med, 1972; 287: 1302.
  • Referans9. Fonnesu, C, Cerquaglia, C, Giovinale, M, et al. Familial Mediterranean Fever: A review for clinical management. Joint Bone Spine, 2009; 76: 227-233.
  • Referans10. Onen, F, Familial Mediterranean fever. Rheumatol Int, 2006; 26(6): 489–96.
  • Referans11. Ben-Chetrit, E, Touitou, I, Familial Mediterranean Fever in the World. Arthritis&Rheumatism, 2009;61:1447-53.
  • Referans12. Lidar, M, Livneh, A, Familial Mediterranean Fever: clinical, molecular and advancements. The Journal of Medicine, 2007; 65 (9): 318-324.
  • Referans13. Turkısh FMF Study Group. Familial Mediterranean Fever in Turkey. Results of a Nationwide Multicenter Study. Medicine, 2005; 84: 1-11.
  • Referans14. Baskın, E, Saatçi, Ü, Familial Mediterranean Fever. Current Rheumatology Reviews, 2006; 2:101-108.
  • Referans15. Kasapçopur, Ö, Arısoy, N, Ailesel Akdeniz Ateşi ve diğer otoenflamatuar hastalıklar. Türk Pediatri Arşivi, 2006; 41; 9-17.
  • Referans16. The international FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause FMF. Cell, 1997; 90:797-807.
  • Referans17. French FMF Consortium. A candidate gene for familial mediterranean fever. Nature Genetics, 1997; 17: 25-31.
  • Referans18. Soylemezoglu, O, Kandur, Y, Gonen, S, Düzova, A, Ozcakar, Z.B, Fidan, K, et al. Familial Mediterrenean fever gene mutation frequencies in a sample Turkish population. Clin Exp Rheumatol, 2016:102(6):97-100.
  • Referans19. Touitou I. Inheritance of autoinflammatory diseases: shifting pradigms and nomenclature. J Med Genet, 2013;50(6):349-59.
  • Referans20. Ozturk, C, Halıcıoglu, O, Coker, I, Gulez, N, Sutçuoglu, S, Karaca, N, et al. Association of clinical and genetical features in FMF with focus on MEFV strip assay sensitivity in 452 children from western Anatolia, Turkey. Clin Rheumatol, 2012;31:493-501.
  • Referans21. Arıcı, Z.S, Bilginer, Y, Özen, S, Ailesel Akdeniz Ateşi: Epidemiyoloji ve Genetik, Türkiye Klinikleri J Rheumatol-Special Topics, 2017;10(1):1-7.
  • Referans22. Manukyan, G, Rustam, A, Update on Pyrifunctions and mechanisms of Familial Mediterrenean Fever. Front. Microbiol, 2016;7:456.
  • Referans23. Wang, D.Q.H, Bonfrate, L, de Bari, O, Wang, T.Y, Portincasa, P, Familial Mediterranean fever: From pathogenesis to treatment. J Genet Syndr Gene Ther, 2014;5:248.
  • Referans24. Tamir, N, Langevitz, P, Zemer, D, Pras, E, Shinar, Y, Padeh, S, et al. Late-onset familial Mediterranean fever (FMF): a subset with distinct clinical, demographic, and molecular genetic characteristics. Am J Med Genet 1999;87(1):30-5.
  • Referans25. Özdel, S, Özçakar, Z.B, Şahin-Kunt, S, Elhan, A.E,Yalçınkaya, F. Late-onset disease is associated With a mild phenotype in children with familial Mediterranean fever. Clin Rheumatol, 2016 Jul;35(7):1837-40.
  • Referans26. Aydın, F, Özçakar, Z.B, Yalçınkaya, F, Çocuklarda Ailesel Akdeniz Ateşi Tanı ve Tedavisi, Türkiye Klinikleri J Rheumatol-Special Topics, 2017;10(1):46-54.
  • Referans27. Saatçi, Ü, Özen, S, Özdemir, S, Bakkaloğlu, A, Beşbaş, N, Topaloğlu, R, Arslan, Ş, Familial mediterranean fever in children: report of a large series and discussion of the risk and prognostic factors of amyloidosis. Eur J Pediatr, 1997; 156: 619-23.
  • Referans28. Sarı, I, Birlik, M, Kasifoğlu, T, Familial Mediterraneanfever: An updated review. Eur J Rheumatol, 2014;1(1):21-33.
  • Referans29. Tunca, M, Akar, S, Onen, F, Ozdogan, H, Kasapcopur, O, Yalcinkaya, F, Et al; Turkish FMF Study Group. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore), 2005; 84(1):1-11.
  • Referans30. Mor, A, Gal, R, Livneh, A, Abdominal and digestive system associations of familial mediterranean fever. Am J Gastroenterol, 2003; 98:2594-604.
  • Referans31. Lidar, M, Pras, M, Langevitz, P, Livneh A, Thoracic and Lung Involvement in Familial Mediaterranean Fever. Clin Chest Med, 2002; 23: 505-511.
  • Referans32. Langevitz, P, Zemer, D, Livneh, A, Shemer, J, Pras, M. Protracted febrile myalgia in patients with Familial Mediterranean Fever. J Rheumatol, 1994; 21: 1708-09.
  • Referans33. Yalcinkaya, F, Tekin, M, Çakar, N, Akar, E, Akar, N, Tümer,N, Familial Mediterrenean fever and systemic amyloidosis in untreated Turkish patients. Q J Med, 2000;93:681-4.
  • Referans34. Yalçinkaya, F, Tümer, N, Glomerular lesions other than amyloidosis in patients with familial Mediterranean fever. Nephrol Dial Transplant, 1999;14(1):21-3.
  • Referans35. Padeh, S, Periodic fever syndromes. Pediatr Clin N Am, 2005; 52:577-609.
  • Referans36. Sohar, E, Gafni,, J, Pras M, Heller, H, FMF: A survey of 470 cases and review of the literature. Am J Med, 1967;43:227-5.
  • Referans37. Livneh, A, Langevitz, P, Zemer, D et al. Criteria for the diagnosis of Familial mediterranean Fever. Arthritis-Rheumatism 1997; 40: 1879-85.
  • Referans38. Yalçınkaya, F, Ozen, S, Ozcakar, Z.B¸ Aktay, N, Çakar, N, Düzova, A, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology, 2009;48: 395-98.
  • Referans39. Kondi, A, Hentgen, V, Piram, M, Letierce, A, Guillaume-Czitrom, S, Koné-Paut, Validation of the new paediatric criteria for the diagnosis of familial Mediterranean fever: data from a mixed population of 100 children from the French reference centre for auto-inflammatory disorders. Rheumatology (Oxford), 2010;49:2200-03.
  • Referans40. Slobodnick, A, Shah, B, Pillinger, M.H, Krasnokutsky, S, Colchicine: Old and New. The American Journal of Medicine, 2015;128:46170.
  • Referans41. Van der Hilst, J.C.H, Moutschen, M, Messiaen, P1, Lauwerys, B.R, Vanderschueren, S, Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature. Biologics, 2016;4(10):75-80.
  • Referans42. Mitroulis, I, Papadopoulos, VP, Konstantinidis, T, Ritis, K, Anakinra suppresses familial Mediterranean fever crises in a colchicine-resistant patient. The Journal of Medicine, 2008; 66: 489-91.
There are 42 citations in total.

Details

Primary Language Turkish
Subjects Paediatrics, Rheumatology and Arthritis
Journal Section Derleme
Authors

Esra Nagehan Akyol Onder 0000-0003-0321-2204

Pelin Ertan 0000-0002-1882-5962

Publication Date September 30, 2020
Published in Issue Year 2020 Volume: 7 Issue: 3

Cite

APA Akyol Onder, E. N., & Ertan, P. (2020). Ailesel Akdeniz Ateşi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 7(3), 413-417. https://doi.org/10.34087/cbusbed.696594
AMA Akyol Onder EN, Ertan P. Ailesel Akdeniz Ateşi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. September 2020;7(3):413-417. doi:10.34087/cbusbed.696594
Chicago Akyol Onder, Esra Nagehan, and Pelin Ertan. “Ailesel Akdeniz Ateşi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 7, no. 3 (September 2020): 413-17. https://doi.org/10.34087/cbusbed.696594.
EndNote Akyol Onder EN, Ertan P (September 1, 2020) Ailesel Akdeniz Ateşi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 7 3 413–417.
IEEE E. N. Akyol Onder and P. Ertan, “Ailesel Akdeniz Ateşi”, CBU-SBED: Celal Bayar University-Health Sciences Institute Journal, vol. 7, no. 3, pp. 413–417, 2020, doi: 10.34087/cbusbed.696594.
ISNAD Akyol Onder, Esra Nagehan - Ertan, Pelin. “Ailesel Akdeniz Ateşi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 7/3 (September 2020), 413-417. https://doi.org/10.34087/cbusbed.696594.
JAMA Akyol Onder EN, Ertan P. Ailesel Akdeniz Ateşi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2020;7:413–417.
MLA Akyol Onder, Esra Nagehan and Pelin Ertan. “Ailesel Akdeniz Ateşi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 7, no. 3, 2020, pp. 413-7, doi:10.34087/cbusbed.696594.
Vancouver Akyol Onder EN, Ertan P. Ailesel Akdeniz Ateşi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2020;7(3):413-7.

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