Iterated bootstrap procedure in individual bioequivalence

Abstract

In this paper, we propose an iterating principle in the bootstrap method to assess the individual bioequivalence under 2×4 randomized crossover design. The finite sample properties of the proposed algorithm are illustrated by an extensive simulation study and a real-world example. Our findings reveal that the proposed idea have better performance than the classical percentile bootstrap confidence limits.

Keywords

• Bioequivalence,bootstrap,hypothesis testing

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