Iterated bootstrap procedure in individual bioequivalence

Year 2019, Volume: 68 Issue: 1, 583 - 594, 01.02.2019

Ufuk Beyaztas

https://doi.org/10.31801/cfsuasmas.438407

Abstract

In this paper, we propose an iterating principle in the bootstrap method to assess the individual bioequivalence under 2×4 randomized crossover design. The finite sample properties of the proposed algorithm are illustrated by an extensive simulation study and a real-world example. Our findings reveal that the proposed idea have better performance than the classical percentile bootstrap confidence limits.

Keywords

Bioequivalence , bootstrap , hypothesis testing

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