Radiant Defense: Harnessing Boron-Based Gel for Shielding Against Radiation-Induced Dermatitis in Rat Models

Year 2024, Volume: 1 Issue: 2, 131 - 138, 14.06.2024

Erhan Ayşan , Ufuk Oguz Idiz , Fikrettin Şahin

Abstract

Objective: Radiation therapy commonly induces dermatitis as a side effect. This study aims to assess the efficacy of a boron-based gel in alleviating radiation-induced dermatitis and explore its potential molecular mechanisms.
Methods: Thirty-two rats were divided into four equal groups: control, boron alone, irradiation alone, and irradiation with boron groups. The boron-based gel was applied to the skin area receiving 30 Gy of irradiation, 30 minutes before exposure. The evaluation of radiation-induced dermatitis was conducted using a skin scoring system, alongside the analysis of tissue expression levels of Bax, Bcl-2, and Bcl-xl proteins.
Results: In the irradiation with boron group, both the skin scores for radiation-induced dermatitis and the levels of Bax protein were significantly lower compared to the radiotherapy-only group (p<0.001, p<0.05 respectively). Bcl-2 expression was reduced in both the irradiation alone and irradiation with boron groups compared to the control group (p<0.05). Additionally, Bcl-xl expression was lower in the irradiation with boron group compared to the other groups (p<0.05).
Conclusion: The application of boron-based gel demonstrates a preferential impact on Bax rather than Bcl-2. Moreover, the use of boron-based gel on the skin effectively reduces radiation-induced dermatitis in rats through a Bax-dependent mechanism.

Keywords

Apoptosis, Bax, Radiation, Rats

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