Joint hypermobility in rheumatoid arthritis: A case- control study

Year 2024, Volume: 1 Issue: 3, 179 - 184, 11.10.2024

Zerrin Kasap , Benay Sarı

https://doi.org/10.70058/cjm.1536334

Abstract

Objective: To evaluate the presence of joint hypermobility (JH) in rheumatoid arthritis (RA) patients and the relationship between JH and disease activity, hand functions, and quality of life.
Methods: Thirty-four seropositive RA patients and 34 controls were included. Demographic data, body mass index, and state of JH (Beighton scores) of all participants were recorded. Two groups were compared in terms of JH. In RA patients, the Disease Activity Score-28 (DAS-28) was used to evaluate disease activity, the Duruöz Hand Index (DHI) for hand functions, and the Nottingham Health Profile (NHP) for quality of life. A correlation analysis was performed to evaluate the relationship of these data with JH in RA patients.
Results: In the RA group, there were no patients with JH. No significant difference was found in the Beighton scores compared to the control group (p=0.383). The Beighton score showed a statistically significant negative correlation with DAS-28, DHI, NHP total, NHP pain, NHP physical activity, and NHP energy level. (p=0.026, p=0.015, p=0.003, p<0.001, p=0.007, p=0.001, respectively).
Conclusion: JH was not detected in patients with RA. Decreased joint mobility may be associated with high disease activity, poor quality of life, and poor hand function.

Keywords

rheumatoid arthritis, joint hypermobility, hand function

References

• Colquhoun M, Gulati M, Farah Z, Mouyis M. Clinical features of rheumatoid arthritis. Medicine. 2022;50(3):138-142.
• Sharif K, Sharif A, Jumah F, Oskouian R, Tubbs RS. Rheumatoid arthritis in review: Clinical, anatomical, cellular and molecular points of view. Clinical Anatomy. 2018;31(2):216-223.
• Kumar B, Lenert P. Joint hypermobility syndrome: recognizing a commonly overlooked cause of chronic pain. The American journal of medicine. 2017;130(6):640-647.
• Grahame R. Hypermobility: an important but often neglected area within rheumatology. Nature clinical practice Rheumatology. 2008;4(10):522-524.
• Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology. 2012;51(suppl_6):vi5- vi9.
• van Gestel AM, Haagsma CJ, van Riel PL. Validation of rheumatoid arthritis improvement criteria that include simplified joint counts. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 1998;41(10):1845-1850.
• Beighton P, Solomon L, Soskolne C. Articular mobility in an African population. Annals of the rheumatic diseases. 1973;32(5):413.
• DURUÖZ MT, POIRAUDEAU S, FERMANIAN J, MENKES C-J. Functional Disability Scale That Assesses Functional. population. 1996;23:1167-72.
• Essink-Bot M-L, Krabbe PF, Bonsel GJ, Aaronson NK. An empirical comparison of four generic health status measures: the Nottingham Health Profile, the Medical Outcomes Study 36-item Short-Form Health Survey, the COOP/WONCA charts, and the EuroQol instrument. Medical care. 1997:522-537.
• Kücükdeveci A, McKenna S, Kutlay S, Gürsel Y, Whalley D, Arasil T. The development and psychometric assessment of the Turkish version of the Nottingham Health Profile. International Journal of Rehabilitation Research. 2000;23(1):31-38.
• Cooney JK, Law R-J, Matschke V, et al. Benefits of exercise in rheumatoid arthritis. Journal of aging research. 2011;2011(1):681640.
• Veldhuijzen van Zanten JJ, Rouse PC, Hale ED, et al. Perceived barriers, facilitators and benefits for regular physical activity and exercise in patients with rheumatoid arthritis: a review of the literature. Sports medicine. 2015;45:1401-1412.
• Metsios GS, Kitas GD. Physical activity, exercise and rheumatoid arthritis: effectiveness, mechanisms and implementation. Best practice & research Clinical rheumatology. 2018;32(5):669- 682.
• Li Z, Wang X-Q. Clinical effect and biological mechanism of exercise for rheumatoid arthritis: A mini review. Frontiers in Immunology. 2023;13:1089621.
• England BR, Smith BJ, Baker NA, et al. 2022 American College of Rheumatology Guideline for exercise, rehabilitation, diet, and additional integrative interventions for rheumatoid arthritis. Arthritis & Rheumatology. 2023;75(8):1299-1311.
• Dwivedi S, Testa EJ, Modest JM, Ibrahim Z, Gil JA. Surgical Management of Rheumatoid Arthritis of the Hand. Rhode Island Medical Journal. 2020;103(4):32-36.
• Santiago MB. Jaccoud-type lupus arthropathy. Lupus. 2022;31(4):398-406.
• Arab Alkabeya H, Hughes AM, Adams J. Factors associated with hand and upper arm functional disability in people with rheumatoid arthritis: a systematic review. Arthritis care & research. 2019;71(11):1473-1481.
• Dellhag B, Burckhardt CS. Predictors of hand function in patients with rheumatoid arthritis. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 1995;8(1):16-20.
• Arslan H, Erdem İH. The effect of an intensive hand exercise program on muscle strength and hand functions in patients with rheumatoid arthritis. Medical Records. 2023;5(3):620-6.
• Bridges AJ, Smith E, Reid J. Joint hypermobility in adults referred to rheumatology clinics. Annals of the Rheumatic Diseases. 1992;51(6):793-796.
• Malek S, Reinhold EJ, Pearce GS. The Beighton Score as a measure of generalised joint hypermobility. Rheumatology international. 2021;41(10):1707-1716.
• Sobhani-Eraghi A, Motalebi M, Sarreshtehdari S, Molazem- Sanandaji B, Hasanlu Z. Prevalence of joint hypermobility in children and adolescents: A systematic review and meta-analysis. Journal of Research in Medical Sciences. 2020;25(1):104.
• Cho S-K, Kim D, Jun J-B, Bae S-C, Sung Y-K. Factors influencing quality of life (QOL) for Korean patients with rheumatoid arthritis (RA). Rheumatology international. 2013;33:93-102.
• Katchamart W, Narongroeknawin P, Chanapai W, Thaweeratthakul P. Health-related quality of life in patients with rheumatoid arthritis. BMC rheumatology. 2019;3:1-8.
• Wan SW, He H-G, Mak A, et al. Health-related quality of life and its predictors among patients with rheumatoid arthritis. Applied Nursing Research. 2016;30:176-183.