Investigation of Parvovirus B19 seropositivity levels in patients with joint pain

Year 2025, Volume: 2 Issue: 3, 144 - 152, 28.10.2025

Selahattin Ünlü , Melahat Gürbüz , Yeliz Çetinkol

https://doi.org/10.70058/cjm.1698938

Abstract

Objective: Parvovirus B19 is a DNA virus belonging to the genus Erythrovirus of the Parvoviridae family, which is widespread worldwide and associated with different clinical pictures. Parvovirus B19 can cause arthritis and arthralgia. In this study, we aimed to compare seropositivity rates in patients with and without joint symptoms.
Methods: In the study, Parvovirus B19 IgG, IgM and PCR results of patients who were studied in the microbiology laboratory between 2020 and 2024 were retrospectively analyzed. Blood samples were evaluated with ELISA-based serologic tests and the presence of viral genome was investigated in PCR tests. In statistical analyses, p<0.05 was considered significant.
Results: Parvovirus B19 IgG seropositivity rate was 33.37% in the group without joint pain, while this rate increased to 50.4% in individuals with joint pain (p=0.00017). In addition, while the IgG positivity rate was 36.18% in women in the group without joint pain, this rate was 58.2% in the group with joint pain (p=0.00058). Parvovirus B19 IgM rates increased from 2.90% in the group without joint pain to 3.20% in the group with joint pain. No positivity was detected in individuals with joint pain in PCR tests.
Conclusion: The seropositivity rate of parvovirus B19 increases with age and is higher in women. The high seropositivity rate in individuals with joint complaints suggests that this infection should be considered in the differential diagnosis of diseases with joint pain, especially rheumatologic diseases. These findings on the epidemiology and clinical presentation of parvovirus B19 are consistent with the literature.

Keywords

Parvovirus B19 , Arthralgia , Serology

Eklem ağrısı olan hastalarda Parvovirus B19 seropozitiflik düzeylerinin araştırılması

Abstract

Amaç: Parvovirus B19, Parvoviridae ailesinin Erythrovirus cinsine ait, dünya genelinde yaygın görülen ve farklı klinik tablolarla ilişkili bir DNA virüsüdür. Parvovirus B19 artrit, artraljiyi neden olabilmektedir. Çalışmada, eklem semptomları olan ve olmayan hastalarda seropozitiflik oranlarının karşılaştırması amaçlandı.
Yöntem: Çalışmada, 2020-2024 yılları arasında mikrobiyoloji laboratuvarında çalışılmış, hastalara ait Parvovirus B19 IgG, IgM ve PCR sonuçları retrospektif olarak analiz edilmiştir. Kan örnekleri ELISA tabanlı serolojik testlerle değerlendirilmiş, PCR testlerinde viral genom varlığı araştırılmıştır. İstatistiksel analizlerde p<0.05 anlamlı kabul edilmiştir.
Bulgular: Eklem ağrısı olmayan grupta Parvovirus B19 IgG seropozitiflik oranı %33.37 iken, eklem ağrısı olan bireylerde bu oran %50.4'e yükselmiştir (p=0.00017). Ayrıca eklem ağrısı olmayan gruptaki kadınlarda IgG pozitiflik oranı, %36.18 iken eklem ağrısı olan grupta bu oran %58.2 bulunmuştur (p=0.00058). Parvovirus B19 IgM oranları eklem ağrısı olmayan grupta %2.90 iken, eklem ağrısı olanlarda %3.20’ye yükselmiştir. PCR testlerinde eklem ağrısı olan bireylerde pozitiflik tespit edilmemiştir.
Sonuç: Parvovirus B19 seropozitiflik oranı yaşla birlikte artmakta ve kadınlarda daha yüksek görülmektedir. Eklem yakınmaları olan bireylerde seropozitiflik oranının yüksek bulunması, bu enfeksiyonun romatolojik hastalıklar başta olmak üzere eklem ağrısı görülen hastalıkların ayırıcı tanısında akılda tutulması gerektiğini düşündürmektedir. Parvovirus B19’un epidemiyolojisi ve klinik prezentasyonu hakkındaki bu bulgular, literatürle uyumludur.

Keywords

Parvovirus B19 , Artralji , Seroloji

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