Case Report
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Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings

Year 2020, , 468 - 472, 30.12.2020
https://doi.org/10.33808/clinexphealthsci.669796

Abstract

Cemento-ossifying fibroma, which is considered a benign mesenchymal odontogenic tumour of the jaws, is a type of fibro-osseous lesion characterized by slow growth and proliferation of fibrous cellular stroma containing osteoid, bone or cementum-like tissue. The aim of this study was to report a case of cemento-ossifying fibroma in the mandible with clinical, radiological, and histopathological findings and surgical treatment. A 37-year-old woman was admitted to our clinic with the complaint of gradually growing painless swelling in the right mandibular premolar area. Intra-oral examination revealed a bony hard and non-tender mass with intact overlying mucosa on the buccal and lingual aspects of the mandibular right premolar teeth. Periapical, panoramic, and cone beam computed tomography images revealed the presence of a multilocular hypodense lesion with bicortical destruction and expansion in the relevant area. Excisional biopsy of the lesion was performed and histopathological examination exhibited the definite diagnosis of cemento-ossifying fibroma. Clinical, radiological, and histopathological examination should be considered in the diagnosis and treatment planning of cemento-ossifying fibroma.

References

  • 1. Liu Y, Wang H, You M, Yang Z, Miao J, Shimizutani K, Koseki T. Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol 2010;39:57‑63.
  • 2. Pandey V, Sharma A, Sudarshan V. Cemento-ossifying fibroma - a rare case report with review of literature. IJCMR 2016;3:2681-2682.
  • 3. Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch 2018;472:331-339.
  • 4. Pindborg JJ, Kramer IRH. Histological typing of odontogenic tumors, jaw cysts and allied lesions. International histological classification of tumors. Geneva: WHO;1971. p.31-34.
  • 5. Kramer IR, Pindborg JJ, Shear M. The World Health Organization histological typing of odontogenic tumours; introducing the second edition. Eur J Cancer B Oral Oncol 1993;29:169-171.
  • 6. Reichart PA, Philipsen HP, Sciubba JJ. The new classification of Head and Neck Tumours (WHO) - any changes? Oral Oncol 2006;42:757-758.
  • 7. El-Mofty SK, Nelson B, Toyosawa S. Ossifying fibroma. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC Press; 2017. p. 251-252.
  • 8. Bala TK, Soni S, Dayal P, Ghosh I. Cemento-ossifying fibroma of the mandible a clinicopathological report. Saudi Med J 2017;38:541-545.
  • 9. Mithra R, Baskaran P, Sathyakumar M. Imaging in the diagnosis of cemento-ossifying fibroma A case series. J Clin Imaging Sci 2012;2:52.
  • 10. Sridevi U, Jain A, Turagam N, Prasad MD. Cemento-ossifying fibroma: A case report. Adv Cancer Prev 2016;1:111.
  • 11. Rani A, Kalra N, Poswal R, Sharma S. Cemento‑ossifying fibroma: Report of a case and emphasis on its diagnosis. Indian J Multidiscip Dent 2017;7:140-143.
  • 12. Dalghous A, Alkhabuli JO. Cemento-ossifying fibroma occurring in an elderly patient: A case report and a review of literature. Libyan J Med 2007;2:95-98.
  • 13. Wanzeler AMV, Rohden D, Arús NA, Silveira HLD, Hildebrand LC. Central cemento-ossifying fibroma: clinical-imaging and histopathological diagnosis. Int J Odontostomat 2018;12:233-236.
  • 14. Silvestre-Rangil J, Silvestre FJ, Requeni-Bernal J. Cemento-ossifying fibroma of the mandible: Presentation of a case and review of the literature. J Clin Exp Dent 2011;3:66-69.
  • 15. Peravali RK, Bhat HH, Reddy S. Maxillo-Mandibular Cemento-ossifying fibroma: A rare case report. J Maxillofac Oral Surg 2015;14:300-307.
  • 16. Kharsan V, Madan RS, Rathod P, Balani A, Tiwari S, Sharma S. Large ossifying fibroma of jaw bone: a rare case report. Pan Afr Med J 2018;30:306.
  • 17. Reddy R, Sarkar P, Manuel RA, Saxena D, Hoisala VR. Cemento-ossifying fibroma: A case report. IJSS Case Reports and Reviews 2016;3:13-15.
  • 18. Neville BW, Damm DD, Allen CMA, Chi AC. Oral and Maxillofacial Pathology. 4th ed. St. Louis, Missouri: Elsevier; 2016.
  • 19. Swami A, Kale L, Mishra S, Choudhary S. Central ossifying fibroma of mandible: A case report and review of literature. J Indian Acad Oral Med Radiol 2015;27:131-135.
  • 20. Atul SK, Bishen KA, Shitalkumar GS. Understanding massive maxillofacial central cement-ossifying fibroma. Indian J Stomatol 2014;5:148-150.
  • 21. Koury ME, Regezi JA, Perrott DH, Kaban LB. Atypical fibro-osseous lesions: diagnostic challenges and treatment concepts. Int J Oral Maxillofac Surg 1995;24:162-169.
  • 22. Regezi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 7th ed. St. Louis, Missoouri: Elsevier; 2016.
Year 2020, , 468 - 472, 30.12.2020
https://doi.org/10.33808/clinexphealthsci.669796

Abstract

Cemento-ossifying fibroma, which is considered a benign mesenchymal odontogenic tumour of the jaws, is a type of fibro-osseous lesion characterized by slow growth and proliferation of fibrous cellular stroma containing osteoid, bone or cementum-like tissue. The aim of this study was to report a case of cemento-ossifying fibroma in the mandible with clinical, radiological, and histopathological findings and surgical treatment.
A 37-year-old female patient was admitted to our clinic with the complaint of gradually growing painless swelling in the right mandibular premolar area. Intra-oral examination revealed a bony hard and non-tender mass with intact overlying mucosa on the buccal and lingual aspect of the mandibular right premolar teeth. Periapical, panoramic, and cone beam computed tomography images revealed the presence of a multilocular hypodense lesion with bicortical destruction and expansion in the relevant area. Excisional biopsy of the lesion was performed and histopathological examination exhibited the definite diagnosis of cemento-ossifying fibroma.
Clinical, radiological, and histopathological examination should be considered in the diagnosis and treatment planning of cemento-ossifying fibroma.

References

  • 1. Liu Y, Wang H, You M, Yang Z, Miao J, Shimizutani K, Koseki T. Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol 2010;39:57‑63.
  • 2. Pandey V, Sharma A, Sudarshan V. Cemento-ossifying fibroma - a rare case report with review of literature. IJCMR 2016;3:2681-2682.
  • 3. Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch 2018;472:331-339.
  • 4. Pindborg JJ, Kramer IRH. Histological typing of odontogenic tumors, jaw cysts and allied lesions. International histological classification of tumors. Geneva: WHO;1971. p.31-34.
  • 5. Kramer IR, Pindborg JJ, Shear M. The World Health Organization histological typing of odontogenic tumours; introducing the second edition. Eur J Cancer B Oral Oncol 1993;29:169-171.
  • 6. Reichart PA, Philipsen HP, Sciubba JJ. The new classification of Head and Neck Tumours (WHO) - any changes? Oral Oncol 2006;42:757-758.
  • 7. El-Mofty SK, Nelson B, Toyosawa S. Ossifying fibroma. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC Press; 2017. p. 251-252.
  • 8. Bala TK, Soni S, Dayal P, Ghosh I. Cemento-ossifying fibroma of the mandible a clinicopathological report. Saudi Med J 2017;38:541-545.
  • 9. Mithra R, Baskaran P, Sathyakumar M. Imaging in the diagnosis of cemento-ossifying fibroma A case series. J Clin Imaging Sci 2012;2:52.
  • 10. Sridevi U, Jain A, Turagam N, Prasad MD. Cemento-ossifying fibroma: A case report. Adv Cancer Prev 2016;1:111.
  • 11. Rani A, Kalra N, Poswal R, Sharma S. Cemento‑ossifying fibroma: Report of a case and emphasis on its diagnosis. Indian J Multidiscip Dent 2017;7:140-143.
  • 12. Dalghous A, Alkhabuli JO. Cemento-ossifying fibroma occurring in an elderly patient: A case report and a review of literature. Libyan J Med 2007;2:95-98.
  • 13. Wanzeler AMV, Rohden D, Arús NA, Silveira HLD, Hildebrand LC. Central cemento-ossifying fibroma: clinical-imaging and histopathological diagnosis. Int J Odontostomat 2018;12:233-236.
  • 14. Silvestre-Rangil J, Silvestre FJ, Requeni-Bernal J. Cemento-ossifying fibroma of the mandible: Presentation of a case and review of the literature. J Clin Exp Dent 2011;3:66-69.
  • 15. Peravali RK, Bhat HH, Reddy S. Maxillo-Mandibular Cemento-ossifying fibroma: A rare case report. J Maxillofac Oral Surg 2015;14:300-307.
  • 16. Kharsan V, Madan RS, Rathod P, Balani A, Tiwari S, Sharma S. Large ossifying fibroma of jaw bone: a rare case report. Pan Afr Med J 2018;30:306.
  • 17. Reddy R, Sarkar P, Manuel RA, Saxena D, Hoisala VR. Cemento-ossifying fibroma: A case report. IJSS Case Reports and Reviews 2016;3:13-15.
  • 18. Neville BW, Damm DD, Allen CMA, Chi AC. Oral and Maxillofacial Pathology. 4th ed. St. Louis, Missouri: Elsevier; 2016.
  • 19. Swami A, Kale L, Mishra S, Choudhary S. Central ossifying fibroma of mandible: A case report and review of literature. J Indian Acad Oral Med Radiol 2015;27:131-135.
  • 20. Atul SK, Bishen KA, Shitalkumar GS. Understanding massive maxillofacial central cement-ossifying fibroma. Indian J Stomatol 2014;5:148-150.
  • 21. Koury ME, Regezi JA, Perrott DH, Kaban LB. Atypical fibro-osseous lesions: diagnostic challenges and treatment concepts. Int J Oral Maxillofac Surg 1995;24:162-169.
  • 22. Regezi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 7th ed. St. Louis, Missoouri: Elsevier; 2016.
There are 22 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Melda Pelin Akkitap 0000-0001-7744-6615

Birsay Gümrü 0000-0002-7734-4755

Ender İdman 0000-0001-7967-841X

Necip Fazıl Erdem 0000-0002-5374-3233

Zeynep Gümüşer 0000-0002-7834-4343

Fatma Aksakallı 0000-0002-2429-9196

Publication Date December 30, 2020
Submission Date January 3, 2020
Published in Issue Year 2020

Cite

APA Akkitap, M. P., Gümrü, B., İdman, E., Erdem, N. F., et al. (2020). Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences, 10(4), 468-472. https://doi.org/10.33808/clinexphealthsci.669796
AMA Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F. Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences. December 2020;10(4):468-472. doi:10.33808/clinexphealthsci.669796
Chicago Akkitap, Melda Pelin, Birsay Gümrü, Ender İdman, Necip Fazıl Erdem, Zeynep Gümüşer, and Fatma Aksakallı. “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”. Clinical and Experimental Health Sciences 10, no. 4 (December 2020): 468-72. https://doi.org/10.33808/clinexphealthsci.669796.
EndNote Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F (December 1, 2020) Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences 10 4 468–472.
IEEE M. P. Akkitap, B. Gümrü, E. İdman, N. F. Erdem, Z. Gümüşer, and F. Aksakallı, “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”, Clinical and Experimental Health Sciences, vol. 10, no. 4, pp. 468–472, 2020, doi: 10.33808/clinexphealthsci.669796.
ISNAD Akkitap, Melda Pelin et al. “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”. Clinical and Experimental Health Sciences 10/4 (December 2020), 468-472. https://doi.org/10.33808/clinexphealthsci.669796.
JAMA Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F. Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences. 2020;10:468–472.
MLA Akkitap, Melda Pelin et al. “Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings”. Clinical and Experimental Health Sciences, vol. 10, no. 4, 2020, pp. 468-72, doi:10.33808/clinexphealthsci.669796.
Vancouver Akkitap MP, Gümrü B, İdman E, Erdem NF, Gümüşer Z, Aksakallı F. Cemento-Ossifying Fibroma: Clinical, Radiological and Histopathological Findings. Clinical and Experimental Health Sciences. 2020;10(4):468-72.

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