The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Year 2022, Volume: 12 Issue: 1, 134 - 140, 30.03.2022

Ayhan Tanyeli , Fazile Nur Ekinci Akdemir , Ersen Eraslan , Mustafa Can Güler , Saime Özbek Şebin , Selim Comaklı İlhami Gülçin

https://doi.org/10.33808/clinexphealthsci.864015

Cited By: 3

Abstract

Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model.
Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated.
Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1β, caspase-3, and TNF-α immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group.
Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.

Keywords

Cecal ligation puncture, sinapic acid, lung, kidney, rat

Supporting Institution

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Thanks

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