The Investigation of Corrosion Performance and Durability of Hydroxyapatite-Coated Titanium Implants and the Effect of Antibiotic Additives

Year 2021, Volume: 36 Issue: 3, 735 - 742, 30.09.2021

Demet Yazıcı Nilgün Alpay , Başak Doğru Mert

https://doi.org/10.21605/cukurovaumfd.1005521

Abstract

In this study, amoxicillin and potassium clavulanate were loaded as antibiotic additives to hydroxyapatite coating (L-HAP) and were used to enhance biocompatibility and corrosion resistance of titanium (Ti) in- vitro conditions. Coating was achieved using the Successive Ionic Layer Adsorption and Reaction (SILAR) process. Scanning electron microscopy (SEM) images, energy dispersive X-ray (EDX) analysis, atomic force microscopy (AFM) images, X-ray diffraction (XRD) analysis, and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) were used to determine the surface morphology. The corrosion test was performed using electrochemical impedance spectroscopy (EIS) and polarization curves in artificial saliva at 310 K. Furthermore the quantum chemical parameters of amoxicillin and potassium clavulanate were investigated and associated with the adsorption ability of these molecules. Results revealed that the corrosion performance of Ti was improved by L-HAP, which had a lower anodic current density and better corrosion resistance. This situation dealt with the more durable, compact film that had been produced on the surface.

Keywords

Artificial saliva, Biocompatibility, SILAR, Titanium

Hidroksiapatit Kaplı Titanyum İmplantların Korozyon Performansı ve Dayanıklılığının ve Antibiyotik Katkı Maddelerinin Etkisinin Araştırılması

Abstract

Bu çalışmada, hidroksiapatit kaplamaya (L-HAP) antibiyotik katkı maddesi olarak ilave edilen amoksisilin ve potasyum klavulanat, in-vitro koşullarda titanyumun (Ti) biyouyumluluğunu ve korozyon direncini arttırmak için kullanılmıştır. Kaplama, Ardışık İyonik Katman Adsorpsiyon ve Reaksiyon (SILAR) yöntemi ile gerçekleştirildi. Yüzey morfolojisi, taramalı elektron mikroskobu (SEM), atomik kuvvet mikroskobu (AFM), enerji dağıtıcı X-ışını (EDX) analizi, X-ışını kırınımı (XRD) analizi, azaltılmış toplam yansıma-Fourier dönüşümlü kızılötesi spektroskopisi (ATR- FTIR) ile belirlendi. Korozyon testleri, elektrokimyasal impedans spektroskopisi (EIS) ve polarizasyon eğrileri yardımıyla 310 K'de yapay tükürük çözeltisinde elde edildi. Ayrıca amoksisilin ve potasyum klavulanatın kuantum kimyasal parametreleri araştırıldı ve bu moleküllerin adsorpsiyon yeteneği ile ilişkilendirildi. Sonuçlar, Ti'nin korozyon performansının, daha düşük anodik akım yoğunluğuna ve daha iyi korozyon direncine sahip olan L-HAP ile iyileştirildiğini ortaya koydu. Bu durum, yüzeyde üretilen daha dayanıklı, kompakt film ile ilişkilendirildi.

Keywords

Yapay tükürük, Biyouyumluluk, SILAR, Titanyum

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