Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood

Hacer Yapıcıoğlu; Ayşe Özkan; Mustafa Yılmaz; Yaşar Sertdemir

doi:10.17826/cutf.280160

TR EN

Yenidoğan döneminde sağlık bakımı ile ilişkili enfeksiyon geçirmiş ve geniş spektrumlu antibiyotik kullanmış olmanın erken çocukluk döneminde gözlenen astma, allerjik rinit ve atopik dermatit üzerine etkisi

Abstract

Amaç: Bu çalışmadaki amacımız yenidoğan döneminde sağlık bakımı ilişkili enfeksiyon (SBİE) geçiren ve geniş spektrumu antibiyotik kullanan çocuklarda astma, allerjjk rinit ve atopic dermatit sıklığını araştırmaktır.

Gereç ve Yöntem: Çalışmaya Yenidoğan Yoğun Bakım Ünitesi’nde 6 yıl içinde izlenen 73 SBİE olan çocuk ile bu çocukların yenidoğan döneminde sağlıklı olan 41 kardeşi alındı. Ebeveynlere detaylı bir anket uygulandı ve çocuklardan tam kan sayımı, serum total Ig Eve spesifik IgE için kan örnekleri alındı.

Bulgular: SBİE olan 73 çocuğun 32’sinde (%45.2) ventilator ilişkili pnömoni, 28’inde (%38.4) kan dolaşımı enfeksiyonu, 12’sinde (%16.4) klinik sepsis gözlenmişti. Astma SBİE grubunda belirgin daha fazla (%32.9’a karşın %4.9) iken allerjik rinit (%4.1’e karşın %2.4) ve atopik dermatit sıklığı farklı değildi (%6,8’e karşın %0). Allerjisi olmayan 85 çocuk ile allerjisi olan 29 çocuk kıyaslandığında, yenidoğan döneminde SBİE geçirmek ve antibiyotik kullanmak allerjik olma oranını 11.5 kat arttırmaktaydı.

Sonuç: SBİE grubunda astma daha sık gözlenmiş olup, yenidoğan döneminde SBİE geçirmek ve geniş spektrumlu antibiyotik kullanmak erken çocukluk döneminde allerji riskini arttırmaktadır.

Keywords

Antibiyotik,allerjik hastalıklar,sağlık bakımı ilişkili enfeksiyon,yenidoğan dönemi

Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood

Abstract

Purpose: The iam of this study was to investigate the effect of healthcare associated infections (HAIs) and broad spectrum antibiotic use in newborn period on asthma, allergic rhinitis and atopic dermatitis.

Material and Methods: Seventy three children treated for HAIs in newborn period in Neonatal Intesive Care Unitin a 6 years period, and their 41 siblings who were healthy in newborn period were included in the study. Parents answered a detailed questionnaire, children were examined and complete blood count, serum total Ig E and specific Ig E levels were studied.

Results: Ventilator associated pneumonia was observed in 32 (45.2%), blood stream infection in 28 (38.4%) and clinic sepsis in 12 (16.4%) of 73 children with HAIs. Asthma was significantly higher in HAIs group compared to sibling group (32.9% vs. 4.9), whereas there was no significant difference in allergic rhinitis (4.1% vs.2.4%) and atopic dermatitis (6.8% vs. 0%) among groups. When non-allergic 85 subjects and allergic 29 children compared, children who had been hospitalised and treated with broad-spectrum antibiotics in newborn period were almost 11.5 times as likely to have an allergic disease.

Conclusion: Asthma was significantly higher in HAI group, and allergic disease risk seems to increase in children treated with broad-spectrum antibiotics for HAIs in newborn period

Keywords

Antibiotics,allergic disease,healthcare associated infection,newborn period.

References

1. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry crosssectional surveys. Lancet. 2006;26:368:733-43.
2. Von Hertzen LC. The hygiene hypothesis in the development of atopy and asthma still a matter of controversy? Q J Med. 1998;91:767-71.
3. Strachan DP. Hay fever, hygiene and household size. BMJ.1989;299:1259-60.
4. Mendall MA, Kumar D. Antibiotic use, childhood affluence and irritable bowel syndrome (IBS). Eur J Gast Hepatol. 1998;10:59-62.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Hacer Yapıcıoğlu
CUKUROVA UNIV

Ayşe Özkan
CUKUROVA UNIV

Mustafa Yılmaz This is me
CUKUROVA UNIV

Yaşar Sertdemir This is me
CUKUROVA UNIV

Publication Date

March 31, 2017

Submission Date

December 22, 2016

Acceptance Date

August 23, 2016

Published in Issue

Year 2017 Volume: 42 Number: 1

DOI

https://doi.org/10.17826/cutf.280160

IZ

https://izlik.org/JA43DR38YW

APA

Yapıcıoğlu, H., Özkan, A., Yılmaz, M., & Sertdemir, Y. (2017). Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood. Cukurova Medical Journal, 42(1), 132-139. https://doi.org/10.17826/cutf.280160

AMA

1.Yapıcıoğlu H, Özkan A, Yılmaz M, Sertdemir Y. Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood. Cukurova Med J. 2017;42(1):132-139. doi:10.17826/cutf.280160

Chicago

Yapıcıoğlu, Hacer, Ayşe Özkan, Mustafa Yılmaz, and Yaşar Sertdemir. 2017. “Effect of Healthcare Associated Infections and Broad Spectrum Antibiotic Use in Newborn Period on Development of Asthma, Allergic Rhinitis and Atopic Dermatitis in Early Childhood”. Cukurova Medical Journal 42 (1): 132-39. https://doi.org/10.17826/cutf.280160.

EndNote

Yapıcıoğlu H, Özkan A, Yılmaz M, Sertdemir Y (March 1, 2017) Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood. Cukurova Medical Journal 42 1 132–139.

IEEE

[1]H. Yapıcıoğlu, A. Özkan, M. Yılmaz, and Y. Sertdemir, “Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood”, Cukurova Med J, vol. 42, no. 1, pp. 132–139, Mar. 2017, doi: 10.17826/cutf.280160.

ISNAD

Yapıcıoğlu, Hacer - Özkan, Ayşe - Yılmaz, Mustafa - Sertdemir, Yaşar. “Effect of Healthcare Associated Infections and Broad Spectrum Antibiotic Use in Newborn Period on Development of Asthma, Allergic Rhinitis and Atopic Dermatitis in Early Childhood”. Cukurova Medical Journal 42/1 (March 1, 2017): 132-139. https://doi.org/10.17826/cutf.280160.

JAMA

1.Yapıcıoğlu H, Özkan A, Yılmaz M, Sertdemir Y. Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood. Cukurova Med J. 2017;42:132–139.

MLA

Yapıcıoğlu, Hacer, et al. “Effect of Healthcare Associated Infections and Broad Spectrum Antibiotic Use in Newborn Period on Development of Asthma, Allergic Rhinitis and Atopic Dermatitis in Early Childhood”. Cukurova Medical Journal, vol. 42, no. 1, Mar. 2017, pp. 132-9, doi:10.17826/cutf.280160.

Vancouver

1.Hacer Yapıcıoğlu, Ayşe Özkan, Mustafa Yılmaz, Yaşar Sertdemir. Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood. Cukurova Med J. 2017 Mar. 1;42(1):132-9. doi:10.17826/cutf.280160

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Yenidoğan döneminde sağlık bakımı ile ilişkili enfeksiyon geçirmiş ve geniş spektrumlu antibiyotik kullanmış olmanın erken çocukluk döneminde gözlenen astma, allerjik rinit ve atopik dermatit üzerine etkisi

Abstract

Keywords

Effect of healthcare associated infections and broad spectrum antibiotic use in newborn period on development of asthma, allergic rhinitis and atopic dermatitis in early childhood

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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