Urinary N-acetyl-β-D-glucosaminidase (NAG) and renal tubular injury in mild preeclampsia
Abstract
Purpose: This study aimed to evaluate the amount of N-acetyl-β-D-glucosaminidase (NAG) in the 24 h urine output of patients with normotensive pregnancies (control) group with mild preeclampsia (study) group and to detect the presence of renal tubular injury in mild preeclampsia patients.
Material and Methods: The study was conducted among 13 patients study group and 15 patients control group. The 24 h urine output and protein, glomerular filtration rate, systolic and diastolic arterial pressures, serum creatinine, and 24 h urine NAG values of the pregnants were calculated.
Results: Statistical difference was not detected among gestational week, 24 h urine volume (mL), serum creatinine (mg/dL), and glomerular filtration rates of the control and the study groups. The differences of the 24 h urine protein (U/l), systolic and diastolic arterial blood pressures (mmHg), and 24 h urine NAG between groups were statistically significant. A significant correlation was found between the NAG values and 24 h urine protein.
Conclusion: This study shows that; evaluating the impact of protein assessment along with NAG, which indicates both glomerular and tubular injuries, is important, and that renal tubular injury occurs in patients with mild preeclampsia but it did not cause any changes of serum creatinine.
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