Effect of endocervical glandular involvement on residual and recurrent disease in patients with high grade cervical dysplasia
Abstract
Purpose: The aim of this study was to evaluate the effect of endocervical glandular involvement on residual and recurrent disease in high-grade cervical dysplasia.
Material and Methods: Patients underwent Loop Electrosurgical Excision Procedure (LEEP) or Cold Knife Conization (CKC) between January 2015 and June 2016 were identified. Patients that had low grade lesions in conization specimens were excluded. The data were collected for age, menopausal status, cytology, colposcopic findings, conization procedure, HPV positivity and subtype, diameters of specimen, number of pieces, pathologic data including status of margins, endocervical glandular involvement (EGI) and recurrence. Prognostic effect of EGI on residual and recurrent disease were evaluated
Results: Of 282 patients, 204 were eligible. Median age was 41 years in both groups. Age, menopausal status, cytology, diameters of specimen, number of pieces, colposcopy findings and conization procedure did not differ between groups.. Surgical margin positivity was higher in EGI positive group. HPV type 16 positivity was significantly higher in EGI positive patients. EGI was found to be the only prognostic factor for residual disease and was not a prognostic factor for recurrent disease.
Conclusion: Our findings showed that EGI appears as a poor prognostic factor for residual disease but not for recurrence in patients with high-grade cervical dysplasia.
Keywords
Endocervical Glandular Involvement,Cervical Dysplasia,Surgical Margin
References
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