Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi

Neslihan Önenli Mungan; Fatih Gürbüz; Eda Mengen; Özden Özgür; Ali Kemal Topaloğlu; Bilgin Yüksel

doi:10.17826/cutf.46470

EN TR

Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi

Abstract

Amaç: Osteogenezis imperfekta bağ dokusunun kalıtsal bir hastalığıdır. Bu durumdaki çocuklar tekrarlayan kırıklar, deformiteler, osteoporosis ve ağrıdan yakınırlar. Son yıllarda pamidronat standart tedavi tercihi olmuştur. Ancak, optimal doz ve aralık henüz tam olarak belirlenmemiştir. Bu çalışmada amaç, iki farklı pamidronat tedavi rejiminin karşılaştırılmasıdır. Materyal ve Metod: Yaşları 42.3 ± 37.4 ay arasında değişen toplam 12 hastada yapıldı. Başlangıçta her iki ayda bir defa 1.5 mg/kg/gün dozunda 23.5 ± 9.0 ay pamidromat infüzyonu uygulandı (ilk protokol), daha sonra üçer aylık aralarla 3 gün üstüste 1 mg/kg/gün 18.5 ± 5.1 ay dozuna geçildi (ikinci protokol). Kemik mineral dansitesi z-skoru yıllık değerlendirildi. Bulgular: Yıllık kırık oranı ilk protokolde 6.3 ± 5.5"den 1.1 ± 1.3"e (p=0.001), ikinci protokolde 1.1 ± 1.3"den 0.0 ± 0.0"a (p

Keywords

Osteogenesiz imperfekta, pamidronat, çocuklar

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Yazışma Adresi / Address for Correspondence: Dr. Fatih GÜRBÜZ Çukurova Üniversitesi Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, ADANA Email: fggurbuz@yahoo.com G eliş tarihi/Received on: 20.01.2014
Kabul tarihi/Accepted on:27.02.2014

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Primary Language

Turkish

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Journal Section

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Authors

Neslihan Önenli Mungan This is me

Fatih Gürbüz This is me

Eda Mengen This is me

Özden Özgür This is me

Ali Kemal Topaloğlu This is me

Bilgin Yüksel This is me

Publication Date

July 22, 2014

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July 22, 2014

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Year 2014 Volume: 39 Number: 3

DOI

https://doi.org/10.17826/cutf.46470

IZ

https://izlik.org/JA47GS67JD

APA

Mungan, N. Ö., Gürbüz, F., Mengen, E., Özgür, Ö., Topaloğlu, A. K., & Yüksel, B. (2014). Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi. Cukurova Medical Journal, 39(3), 532-539. https://doi.org/10.17826/cutf.46470

AMA

1.Mungan NÖ, Gürbüz F, Mengen E, Özgür Ö, Topaloğlu AK, Yüksel B. Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi. Cukurova Med J. 2014;39(3):532-539. doi:10.17826/cutf.46470

Chicago

Mungan, Neslihan Önenli, Fatih Gürbüz, Eda Mengen, Özden Özgür, Ali Kemal Topaloğlu, and Bilgin Yüksel. 2014. “Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi”. Cukurova Medical Journal 39 (3): 532-39. https://doi.org/10.17826/cutf.46470.

EndNote

Mungan NÖ, Gürbüz F, Mengen E, Özgür Ö, Topaloğlu AK, Yüksel B (September 1, 2014) Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi. Cukurova Medical Journal 39 3 532–539.

IEEE

[1]N. Ö. Mungan, F. Gürbüz, E. Mengen, Ö. Özgür, A. K. Topaloğlu, and B. Yüksel, “Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi”, Cukurova Med J, vol. 39, no. 3, pp. 532–539, Sept. 2014, doi: 10.17826/cutf.46470.

ISNAD

Mungan, Neslihan Önenli - Gürbüz, Fatih - Mengen, Eda - Özgür, Özden - Topaloğlu, Ali Kemal - Yüksel, Bilgin. “Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi”. Cukurova Medical Journal 39/3 (September 1, 2014): 532-539. https://doi.org/10.17826/cutf.46470.

JAMA

1.Mungan NÖ, Gürbüz F, Mengen E, Özgür Ö, Topaloğlu AK, Yüksel B. Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi. Cukurova Med J. 2014;39:532–539.

MLA

Mungan, Neslihan Önenli, et al. “Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi”. Cukurova Medical Journal, vol. 39, no. 3, Sept. 2014, pp. 532-9, doi:10.17826/cutf.46470.

Vancouver

1.Neslihan Önenli Mungan, Fatih Gürbüz, Eda Mengen, Özden Özgür, Ali Kemal Topaloğlu, Bilgin Yüksel. Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi. Cukurova Med J. 2014 Sep. 1;39(3):532-9. doi:10.17826/cutf.46470

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi

Evaluation of Two Different Pamidronate Treatment Protocols in Children with Osteogenesis Imperfecta

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Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi

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