Meme Kanseri Cerrahisinde Gabapentin Uygulamasının Preoperatif Anksiyete ve Postoperatif Analjezi Üzerine Etkisi

Seda Kişi; Ersel Güleç; Mediha Türktan; Zehra Hatipoğlu; Yasemin Güneş

doi:10.17826/cutf.82013

EN TR

The Effect of Gabapentin on Preoperative Anxiety and Postoperative Analgesia in Breast Cancer Surgery

Abstract

Purpose: The goal of this study was to evaluate the effect of pre-emptive gabapentin administration on anxiety and on postoperative tramadol requirement in patients undergoing breast cancer surgery. Material and Methods: After obtaining the local ethics committee approval and written informed consent, sixty-two patients with ASA physical status I-II aged 18-60 years and scheduled for breast cancer surgery were included into our study. They were randomly allocated into two groups. As control group did not receive premedication, the other group received 600 mg gabapentin per orally. We performed STAI-2 (The State-Trait Anxiety Inventory-2) and preoperatively STAI-1 (The State-Trait Anxiety Inventory-1) in both groups. Heart rate, systolic and diastolic blood pressure were recorded intraoperatively. 30 minutes before the end of surgery, 1mg.kg-1 tramadol was administered intravenously for postoperative analgesia. Patient controlled analgesia device was used intravenously to provide postoperative analgesia. Postoperative VAS scores and postoperative tramadol requirement at 5, 10, 15, 30, 45th and 60th minutes and at 4, 8, 12, 24th hours were recorded. Results: Demographic data, hemodynamic values during the surgery, and anxiety scores were not different between two groups. Heart rate at 10th and 60th minutes intraoperatively, tramadol requirement and VAS scores postoperatively were significantly reduced in gabapentin group compared with control group (p

Keywords

Anxiety, Gabapentin, Patient controlled analgesia, Pre-emptive analgesia

Meme Kanseri Cerrahisinde Gabapentin Uygulamasının Preoperatif Anksiyete ve Postoperatif Analjezi Üzerine Etkisi

Öz

Amaç: Bu çalışmada meme kanseri nedeniyle opere olacak olgularda preemptif amaçlı uygulanan oral gabapentinin preoperatif anksiyete ve postoperatif ağrı kontrolü üzerindeki etkilerinin karşılaştırılması amaçlanmıştır. Materyal ve Metod: Çalışmaya yaşları 18-60 yaş arasında değişen ASA I-II grubu toplam 62 meme kanserli olgu alınmış olup çalışma prospektif, randomize ve çift kör olarak yürütülmüştür. Olgular iki gruba ayrılmış ve hepsine preoperatif Sürekli Kaygı Ölçeği uygulanmıştır. Birinci gruptaki olgulara operasyondan bir saat öncesi gabapentin 600 mg tablet oral yoldan verilmiş, cerrahiden hemen önce Durumluluk Kaygı Ölçeği uygulanırken 2. gruptaki olgulara yalnızca operasyon öncesi Durumluluk Kaygı Ölçeği uygulanmıştır. Her iki gruba da postoperatif analjezi amacıyla operasyon bitiminden 30 dk önce 1mg/kg i.v. tramadol uygulanmıştır. Postoperatif ağrıyı değerlendirmek amacıyla postoperatif Vizüel Analog Skala değerleri ile total tramadol tüketimi değerlendirilmiştir. Bulgular: Her iki grubun demografik özellikleri, operasyon süreleri, hemodinamik değerleri ve anksiyete skorları birbirine benzer olup intraoperatif 10. ve 60. dakikalarda ölçülen kalp atım hızı değerleri, postoperatif 24 saatte toplam tramadol tüketimi, postoperatif 5., 10. dk ve 6. saat dışındaki VAS değerleri gabapentin verilen grupta kontrol grubuna göre anlamlı düzeyde düşük bulunmuştur (p

Anahtar Kelimeler

Anksiyete, Gabapentin, Hasta kontrollü analjezi, Preemptif analjezi

References

Kisane DW, Grabsch B. Psychiatric disorder in Romen with early stage and advanced breast cancer: a comperative analysis. Australian and New Zeland Journal of Psychiatry. 2004;38:320-6.
Lithner M, Zilling T. Pre and postoperative information needs. Patient Education and Counselling. 2000;40:29-37.
Shuldham C. A review of the impact of pre-operative education on recovery from surgery. International Journal of Nursing Studies. 1999;36:171-7.
Sjöling M, Nordahl G, Olofsson N, Asplund K. The impact of preoperative information on state anxiety, postoperative pain and satisfaction with pain management. Patient Education and Counselling. 2003;51:169-76.
Price B. Body Image Nurcing Concepts and Care. New York, London, Prentice Hall. 1990;234-43.
Suominen T, Leino-Kilpi H, Loupitta P. ”Who provides support and how”. Cancer Nursing, Volume 18 Number 14. Philadelphia, Lippincott-Raen Publishers. 1995;278-85.
Marks K, Nelson C, Lautenschlayer P. Antibiotic impregrated acrylic bone cement. J Bone and Joint Surg. 1976;58-A:358-64.
Tang R, Evans H, Chaput A, Kim C. Multimodal analgesia for hip arthroplasty. Orthop Clin North Am. 2009;40:377-87.
Casali R, Lepri A, Cantini Q, Landi S, Novelli GP. Comparative study of the effects of morphine and tramadol in the treatment of postoperative pain. MinervaAnestesiol. 2000;66:147-52.
Austrup ML, Korean G. Analgesic agents for the postoperative period. Opioids. Surg Clin North Am. 1999;79:253-73.

Johnson FN, Johnson RD, Martin L, Armer ML. Gabapentin in the treatment of neuropathic pain. Rev Contemp Pharmacother. 2001;12:125-6.
Turan A, Memiş D, Kaıamanlıoğlu B, Yağız R, Pamukçu Z, Yavuz E. Analgesic effects of gabapentin in ear-nose-throat surgery. Anesth Analg. 2004;99:375-8.
Menigaux C, Adam F, Guignard B. Preoperative Gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg. 2005;100:1394
Tirault M, Foucan L, Debaene B. Gabapentin premedication: assessment of preoperative anxiolysis and postoperative patient satisfaction. Acta Anaesthesiol Belg. 2010;61:203-9.
Weis OF, Sriwatanakul K, Weintraub M et al. Reduction of anxiety and postoperative analgesic requirements by audiovisual instruction. Lancet 1983;1:43.
Rowbothm DJ. Gabapentin: a new drug for postoperative pain? Editorial II. Br J Anaesth. 2006;96:152-5.
Singh L, Field MJ, Ferris P. The antiepileptic agent gabapentin possesses anxiolyticlike and antinosiseptive actions that are reversed by D-serine. Pshychopharmacology. 1996;127:1-9.
Johnson FN, Johnson RD, Martin L, Armer ML. Gabapentin in the treatment of neuropathic pain. Rev Contemp Pharmacother. 2001;12:125-6.
Magnus L. Nonepileptic uses of gabapentin. Epilepsia. 1999;40:66-72.
White PF, Tufanoğulları B, Taylor J. The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. Anesth Analg. 2009;108:1140-5
Nutt D, Mandel F, Baldinetti F. Early onset anxiolytic efficacy after a single dose of pregabalin: doubleblind, placebo- and active-comparator controlled evaluation using a dental anxiety model. J Psychopharmacol. 2009;23:867.
Gonano C, Latzke D, Sabeti-Aschraf M, Kettner SC. The anxiolytic effect of pregabalin in outpatients undergoing minor orthopaedic surgery. J Psychopharmacol. 2011;25:249.
Syal K, Goma M, Dogra RK et al. ‘Protective premedicatio’: a comparative study of acetaminophen, gabapentin and combination of acetaminophen with gabapentin for postoperative analgesia. J Anaesthesiol Clin Pharmacol. 2010;26:531-6.
Dirks J, Peterson KL, Rowbotham MC, Dahl JB. Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization. Anaesthesiology. 2002;97:102-7.
Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, Singh RB, Singh U, Singh PK. Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. JNeurosurg Anesthesiol. 2005;17:65-8.
Grover VK, Mathew PJ, Yaddanapudi S, Sehgal S. A single dose of preoperative gabapentin for pain reduction and requirement of morphine after total mastectomy and axillary dissection: randomized placebo-controlled double-blind trial. J Postgrad Med. 2009;55:257-60.
Turan A, Karamanlıoğlu B, Memiş D, Uşar P, Pamukçu Z, Türe M. The analgesic effects of gabapentin after abdominal hysterectomy. Anesth Analg. 2004;98:1370-3. Turan A , Karamanlıoğlu B, Memiş D, Hamamcıoğlu
MK, Tükenmez B, Pamukçu Z. Analgesic effect of gabapentin after spinal surgery. Anesthesiology. 2004;100:935-8.
Yazışma Adresi / Address for Correspondence: Dr. Ersel Güleç Çukurova Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon Anabilim Dalı 01330, Balcalı Hastanesi Sarıçam/Adana Tlf: 0 322 338 6060/3289
Email: gulecersel@yahoo.com geliş tarihi/received :09.12.2013 kabul tarihi/accepted:13.01.2014

Details

Primary Language

Turkish

Subjects

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Journal Section

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Authors

Seda Kişi This is me

Ersel Güleç This is me

Mediha Türktan This is me

Zehra Hatipoğlu This is me

Yasemin Güneş This is me

Publication Date

July 22, 2014

Submission Date

July 22, 2014

Acceptance Date

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Published in Issue

Year 2014 Volume: 39 Number: 2

DOI

https://doi.org/10.17826/cutf.82013

IZ

https://izlik.org/JA83UC88AF

MLA

Kişi, Seda, et al. “Meme Kanseri Cerrahisinde Gabapentin Uygulamasının Preoperatif Anksiyete Ve Postoperatif Analjezi Üzerine Etkisi”. Cukurova Medical Journal, vol. 39, no. 2, June 2014, pp. 315-22, doi:10.17826/cutf.82013.

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Effect of Gabapentin on Preoperative Anxiety and Postoperative Analgesia in Breast Cancer Surgery

Abstract

Keywords

Meme Kanseri Cerrahisinde Gabapentin Uygulamasının Preoperatif Anksiyete ve Postoperatif Analjezi Üzerine Etkisi

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

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Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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