Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri

Okan Bakıner; Emre Bozkırlı; Hülya Serinsöz; Çağla Sarıtürk; Eda Ertörer

EN TR

Assessment of prenatal and perinatal characteristics of pregnants with gestationel diabetes mellitus who have postnatal glucose abnormalities

Abstract

Purpose: To examine the difference in terms of prenatal and perinatal characteristics between gestational diabetic (GDM) cases diagnosed with impaired fasting glucose (IFG)and impaired glucose tolerance (IGT) during early postpartum period. Material and Methods: Cases who had no history of any glucose metabolism disorder and diagnosed as GDM due to American Diabetes Association (ADA) criteria were included. Subjects were inquired for pregestational characteristics(glucose abnormality in previous pregnancies, birth of macrosomic baby and history of diabetes in a first-degree relative), prenatal characteristics (age, body mass index BMI), features at diagnosis (BMI,weight-gain ,blood pressure and HbA1C), and perinatal characteristics (birth week and baby birth weight) were recorded. Oral glucose tolerance test (OGTT) was reperformed in the 6th postpartum week. Effects of pregestational, prenatal and perinatal features on postpartum glucose abnormalities were analysed. Results: Out of 80 cases who completed the study 58.7%(n=47) had normal glucose metabolism, 13.7%( n=11) had IFG and 27.5%(n=22) had IGT. No difference was found between pregestational, prenatal , perinatal characteristics, features at the time of diagnosis and postpartum OGTT results. Incidence of IFG in postpartum OGTT for those who had diabetes in a first degree relative was elevated when compared with other cases(p=0,042). The difference was preserved after adjustment for other characteristic features with multivariate analysis (p=0,037). Conclusion: Presence of diabetes in a first degree relative may be a risk factor for postnatal early IFG. In our study other pregestational, prenatal, perinatal factors and features at diagnosis didn"t affect early postpartum glucose metabolism.

Keywords

Gestational diabetes, impaired fasting glucose, impaired glucose tolerance

Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri

Abstract

Amaç: Gestasyonel diyabetes mellitus( GDM) olan ve postpartum erken dönemde bozulmuş açlık glukozu (BAG) ve bozulmuş glukoz toleransı (BGT) tanısı alan olgularda antenatal ve perinatal risk faktörleri açısından fark olup olmadığını araştırmak. Materyal ve Metod: Obstetrik polikliniğinde spontan gebelik takibinde olup GDM tanısı konan ve öyküsünde bilinen glukoz anormalliği olmayan olgular çalışmaya alındı.Olguların geçmişte GDM varlığı, makrosomik bebek doğurma öyküsü ve ailesinde tip-2 diyabet varlığı sorgulandı.Yaş,prekonsepsiyonel ve tanıda vücut-kitle indeksi (VKİ), tanıya kadar alınan kilo, kan basınçları ile tanıdaki HbA1C düzeyleri kaydedildi. Takipte insülin tedavisi başlananlar kaydedildi. Doğum haftası, doğuma kadar alınan toplam kilo, bebeğin doğum kilosu kaydedildi. Postpartum 6. Haftada OGTT uygulandı. Olgular postpartum normal, bozulmuş açlık glukozu(BAG) ve bozulmuş glukoz toleransı (BGT) olarak gruplandırıldı. İstatistiksel analizlerle antenatal ve perinatal özelliklerin doğum sonrası glukoz anormalliklerine etkisi olup olmadığı incelendi. Bulgular:Çalışmayı tamamlayan 80 olgudan postpartum 6. Haftada yapılan OGTT sonrasında %58,7 si normal glukoz metabolizması (n=47),%13,7 "si BAG ( n=11) ve %27,5 "i BGT (n=22) olarak saptandı. Ailesinde diyabet olanlarda BAG görülme sıklığının normallere ve BGT grubuna göre anlamlı artmış olduğu gözlendi (p=0,042). Yine takipte insülin başlananlarda (n=41) BAG görülme sıklığının arttığıbelirlendi (p=0,039). Prenatal ve perinatal diğer özelliklerden hiçbirisi üç gruptada farklılık göstermedi. Yapılan multivaryant analiz sonrası ailede diyabet varlığının postpartum erken dönem BAG için bağımsız risk faktörü olduğu tespit edildi (p=0,037). Risk analizinde ailesinde diyabet olanların (%25-80 güven aralığında) 1,7 kat artmış doğum sonrası BAG riskine sahip olduğu saptandı. Sonuç: Ailede diyabet varlığı gestasyonel diyabetik olgularda postpartum erken dönemde BAG varlığı için bir risk faktörü olabilir.

Keywords

Gestasyonel diyabet, bozulmuş açlık glukozu, bozulmuş glukoz toleransı

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Yazışma Adresi / Address for Correspondence: Dr. Okan Bakıner Başkent Üniversitesi Tıp Fakültesi Adana Uygulama ve Araştırma Hastanesi Endokrinoloji ve Metabolizma Hastalıkları Kliniği Yüreğir/ADANA e-mail; okanbakiner@mynet.com geliş tarihi/received :26.02.2013 kabul tarihi/accepted:01.04.2013

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Turkish

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Authors

Okan Bakıner This is me

Emre Bozkırlı This is me

Hülya Serinsöz This is me

Çağla Sarıtürk This is me

Eda Ertörer This is me

Publication Date

December 1, 2013

Submission Date

July 22, 2014

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Year 2013 Volume: 38 Number: 4

IZ

https://izlik.org/JA54JS66BK

APA

Bakıner, O., Bozkırlı, E., Serinsöz, H., Sarıtürk, Ç., & Ertörer, E. (2013). Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri. Cukurova Medical Journal, 38(4), 617-626. https://izlik.org/JA54JS66BK

AMA

1.Bakıner O, Bozkırlı E, Serinsöz H, Sarıtürk Ç, Ertörer E. Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri. Cukurova Med J. 2013;38(4):617-626. https://izlik.org/JA54JS66BK

Chicago

Bakıner, Okan, Emre Bozkırlı, Hülya Serinsöz, Çağla Sarıtürk, and Eda Ertörer. 2013. “Gestasyonel Diyabeti Olan Gebelerin Prenatal Ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri”. Cukurova Medical Journal 38 (4): 617-26. https://izlik.org/JA54JS66BK.

EndNote

Bakıner O, Bozkırlı E, Serinsöz H, Sarıtürk Ç, Ertörer E (December 1, 2013) Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri. Cukurova Medical Journal 38 4 617–626.

IEEE

[1]O. Bakıner, E. Bozkırlı, H. Serinsöz, Ç. Sarıtürk, and E. Ertörer, “Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri”, Cukurova Med J, vol. 38, no. 4, pp. 617–626, Dec. 2013, [Online]. Available: https://izlik.org/JA54JS66BK

ISNAD

Bakıner, Okan - Bozkırlı, Emre - Serinsöz, Hülya - Sarıtürk, Çağla - Ertörer, Eda. “Gestasyonel Diyabeti Olan Gebelerin Prenatal Ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri”. Cukurova Medical Journal 38/4 (December 1, 2013): 617-626. https://izlik.org/JA54JS66BK.

JAMA

1.Bakıner O, Bozkırlı E, Serinsöz H, Sarıtürk Ç, Ertörer E. Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri. Cukurova Med J. 2013;38:617–626.

MLA

Bakıner, Okan, et al. “Gestasyonel Diyabeti Olan Gebelerin Prenatal Ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri”. Cukurova Medical Journal, vol. 38, no. 4, Dec. 2013, pp. 617-26, https://izlik.org/JA54JS66BK.

Vancouver

1.Okan Bakıner, Emre Bozkırlı, Hülya Serinsöz, Çağla Sarıtürk, Eda Ertörer. Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri. Cukurova Med J [Internet]. 2013 Dec. 1;38(4):617-26. Available from: https://izlik.org/JA54JS66BK

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Assessment of prenatal and perinatal characteristics of pregnants with gestationel diabetes mellitus who have postnatal glucose abnormalities

Abstract

Keywords

Gestasyonel Diyabeti Olan Gebelerin Prenatal ve Perinatal Özelliklerinin Postpartum Erken Glukoz Metabolizması Üzerine Etkileri

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References

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