Agranulocytosis after Metamizole Sodium Use

Year 2015, , 580 - 583, 30.09.2015

Eren Çağan , Havva Çağan Duygu Sürmelihindi

https://doi.org/10.17826/cutf.09574

Abstract

Metamizole sodium (Novalgine) is commonly used as an antipyretic, analgesic, and spasmolytic agent in some parts of the world and our country; however, it is banned in developed countries because of severe side effects. Here we present a case of a three-years- four- months-old girl who developed life-threatening agranulocytosis in his bone marrow after metamizole sodium use for fever, which resolved with granulocyte colony-stimulating factor therapy.

Keywords

-

Metamizol Sodyum Kullanımına Bağlı Agranülositoz

Abstract

Metamizol sodyum (Novalgine) ülkemizde ve dünyanın birçok yerinde antipiretik, aneljezik ve spazmolik olarak yaygın olarak kullanılmaktadır. Ancak gelişmiş ülkelerde şiddetli yan etkilerinden dolayı kullanılmamaktadır. Bu yazıda ateş nedeni ile metamizol sodyum kullanılan ve metamizol sodyum sonrasında kemik iliğinde agranülositoz gelişen ve granülosit koloni-uyarıcı faktör ile tedavi edilen üç yaş dört aylık bir kız hasta sunulmuştur.

Keywords

Agranülositoz, Metamizol, Çocuk, Ateş

References

• 1. Ramacciotti AS, Soares BG, Atallah AN. Dipyrone for acute primary headaches. Cochrane Database Syst Rev. 2007;(2):CD004842.
• 2. Arellano F, Sacristan JA. Metamizole: reassessment of its therapeutic role. Eur J Clin Pharmacol. 1990;38:617-9.
• 3. Basak GW, Drozd-Sokolowska J, Wiktor-Jedrzejczak W. Update on the incidence of metamizole sodiuminduced blood dyscrasias in Poland. J Int Med Res. 2010;38:1374-80.
• 4. van der Klauw MM, Goudsmit R, Halie MR, van't Veer MB, Herings RM, Wilson JH, et al. A populationbased case-cohort study of drug-associated agranulocytosis. Arch Intern Med. 1999;159:369-74.
• 5. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-65.
• 6. Kaufman DW, Kelly JP, Jurgelon JM, Anderson T, Issaragrisil S, Wiholm BE, et al. Drugs in the aetiology of agranulocytosis and aplastic anaemia. Eur J Haematol Suppl. 1996;60:23-30.
• 7. Billekop K, Mosbech J. [Mortality from agranulocytosis in Denmark during the period 1958- 1972]. Ugeskr Laeger 1976;138:1697-9.
• 8. Wiholm BE, Emanuelsson S. Drug-related blood dyscrasias in a Swedish reporting system, 1985- 1994. Eur J Haematol Suppl. 1996;60:42-6.
• 9. Kaufman DW, Kelly JP, Issaragrisil S, Laporte JR, Anderson T, Levy M, et al. Relative incidence of agranulocytosis and aplastic anemia. Am J Hematol. 2006;81:65-7.
• 10. Kaufman DW, Kelly JP, Jurgelon JM, Anderson T, Issaragrisil S, Wiholm BE, et al. Drugs in the aetiology of agranulocytosis and aplastic anaemia. Eur J Haematol Suppl. 1996;60:23-30.
• 11. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-65.
• 12. Andres E, Maloisel F, Zimmer J. The role of haematopoietic growth factors granulocyte colonystimulating factor and granulocyte-macrophage colony-stimulating factor in the management of druginduced agranulocytosis. Br J Haematol. 2010;150:3- 8.
• 13. Thomas D Coates.UpToDate_2014. Drug-induced neutropenia and agranulocytosis. Topic 8374 Version 20.0Topic 8374 Version 20.0. Jennifer S Tirnauer, editor. 7-4-2014. Ref Type: Online Source.
• 14. Hedenmalm K, Spigset O. Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). Eur J Clin Pharmacol. 2002;58:265-74.
• 15. Tajiri J, Noguchi S, Murakami N. Usefulness of granulocyte count measurement four hours after injection of granulocyte colony-stimulating factor for detecting recovery from antithyroid drug-induced granulocytopenia. Thyroid. 1997;7:575-8.