Role of the Hereditary Thrombophilic Abnormalities in Retinal Vein Occlusions

Year 2015, , 723 - 729, 02.10.2015

Handan Canan , A.nihal Demircan

https://doi.org/10.17826/cutf.28275

Abstract

Purpose: The aim of our study was to evaluate the relation between hereditary thrombophilic factors leading to coagulation disorders and retinal vein occlusion (RVO). Material and Methods: A total of 45 consecutive patients with RVO group and 42 healty subjects (Control group) were enrolled. The mean follow-up period was 15.2±5.5 months. The following investigations were performed in both groups: Factor V Leiden (FVL), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) enzyme mutations, antithrombin III, protein C and S activities, fibrinogen, factor VII and VIII levels, D-dimer, activated partial thromboplastin time and prothrombin time/INR, complete blood count, ESR and blood biochemistry. Results: Factor V leiden heterozygote mutation was found in four (9%) patients in RVO and one (2.4%) in Control groups. Homozygote FVL mutation and PT G20210A mutation were not found in neither of the groups. In the RVO group, 26 patients (57.8%) had MTHFR C677T heterozygote mutation and four (8.9%) had homozygote mutation. In the Control group 14 (33.3%) patients had MTHFR C677T heterozygote mutation and four (9.5%) had homozygote mutation. There was a significant difference in MTHFR C677T genotype distribution between the 2 groups (p=0,032). The serum triglyceride, glucose, fibrinogen and ESR levels were significantly higher in patients compared to the controls Conclusion: We believe that, in addition to all related systemic and ophthalmological investigations, hematological screening tests to detect hypercoagulation should be performed while investigating the etiology in patients with RVO.

Keywords

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Retinal Ven Tıkanıklıklarında Herediter Trombofilinin Rolü

Abstract

Amaç: Çalışmamızda retina ven tıkanıklıkları (RVT) ile koagülasyon bozukluklarına yol açan herediter trombofili faktörleri arasındaki ilişkiyi incelemeyi amaçladık. Materyal ve Metod: Çalışmamıza 45 hasta RVT grubu olarak, 42 sağlıklı olgu kontrol grubu olarak dahil edildi. Takip süresi ortalama 15.2±5.5 aydı. Her 2 grupta Faktör V Leiden (FVL), protrombin G20210A ve metilentetrahidrofolat redüktaz (MTHFR) enzim mutasyonu, antitrombin III, protein C ve S aktivitesi, fibrinojen, faktör VII ve VIII seviyeleri, Ddimer, aktive parsiel tromboplastin zamanı, protrombin zamanı/INR, CBC, ESR ve tam kan biyokimyası incelemeleri yapıldı. Bulgular: RVT grubunda 4 (%9), kontrol grubunda ise 1 (%2.4) olguda FVL heterozigot mutasyonu tespit edildi. Her 2 grupta da homozigot FVL mutasyonu ve PT G20210A mutasyonu tespit edilmedi. RVT grubunda 26 (%57.8) hastada heterozigot, 4 olguda (%8.9) homozigot MTHFR C677T mutasyonu tespit edildi. Kontrol grubunda ise 14 (%33.3) olguda heterozigot ve 4(%9.5) olguda ise homozigot MTHFR C677T mutasyonu vardı. Gruplar arasında MTHFR C677T mutasyonu açısından istatistiksel olarak anlamlı fark vardı (p=0,032). RVT grubunda serum trigliserid, glukoz , fibrinojen ve ESR seviyeleri kontrol grubuna göre belirgin olarak yüksek bulundu. Sonuç: RVT olan hastaların etyolojisini araştırırken tüm ilişkili sistemik ve oftalmolojik muayenenin yanısıra hiperkoagülasyon değerlendirmesi için hematolojik testlerin yapılması gerektiğini düşünmekteyiz.

Keywords

Kalıtsal trombofili, Retina ven tıkanıklığı

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