Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients

Year 2015, , 746 - 756, 02.10.2015

Eddy Salim Radiyati Partan Muhammad Mukti Syarifuddin Muhammad Hermansyah Hermansyah

https://doi.org/10.17826/cutf.74353

Abstract

Purpose: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone. An increase of weight bearing affect on knee joint biomechanically and alter concentration of adipokines, such as adiponectin and leptin. Herein we reported a correlation between adiponectin and leptin synovial fluid concentration with the severity of knee OA in obese patients. Material and Methods: Totally 45 patients were included in this research. ELISA was used to determine adiponectin and leptin concentrations of synovial fluid. The severity of knee OA was classified by Kellgren-Lawrence grading scale. Data analysis was conducted using SPSS for windows. Results: Based on the leptin measurement, it was shown that leptin concentrations were correlated positively with the severity of knee OA. Vice versa, adiponectin concentrations were correlated negative. Conclusion: Our study was support the biomarker function of adiponectin and leptin concentration on synovial fluids, in which those concentrations were related with the severity of OA. Those results also suggested the function of leptin and adiponectin on OA.

Keywords

Adiponectin; Knee osteoarthritis; Kellgren-Lawrence; Leptin; Obese

Obez Hastalarda Diz Osteoartrit Şiddetinin Göstergesi Olarak Sinoviyal Sıvıda Adinopektin ve Leptin Konsantrasyonu

Abstract

Amaç: Osteoartrit (OA), eklem kıkırdak kaybı,osteofit oluşumu ve kıkırdak altındaki kemikte meydana gelen değişimlerle karakterize edilen, oynar eklemin kronik dejeneratif eklem hastalığıdır. Vücut ağırlığının artması, diz eklemlerini biyokimyasal olarak etkiler, adiponektin ve leptin gibi adipokinlerin konsantrasyonunu değiştirir. Bu çalışmada obez hastalarda, adiponektin ve leptin sinoviyal sıvı konsantrasyonu ile diz osteoartrit şiddeti arasında korelasyon saptanmıştır. Materyal ve Metod: Çalışmaya 45 hasta dahil edilmiştir. Sinoviyal sıvıda adiponektin ve leptin konsantrasyonlarının saptanmasında ELISA kullanılmıştır. Diz OA’sının şiddeti Kellgren-Lawrence derecelendirmesi ile yapılmıştır. Data analizleri SPSS ile yapılmıştır. Bulgular: Leptin ölçümlerine göre, leptin konsantrasyonları diz OA’sının şiddeti ile pozitif korelasyon göstermektedir. Bunun aksine adiponektin konsantrasyonları negatif korelasyon göstermektedir. Sonuç: Bu çalışma, OA’nın şiddeti ile sinovial sıvıdaki adiponektin ve leptin konsantrasyonları arasında bir ilişki olduğundan, adiponektin ve leptinin biomarker fonksiyonuna sahip olduğunu desteklemektedir. Sonuçlar aynı zamanda leptin ve adiponektinin OA üzerinde fonksiyonu olduğunu göstermektedir

Keywords

Adiponektin; diz osteoartriti; Kellgren-Lawrence; Leptin; Obez

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