First Episode Mania Probably Associated with Discontinuation of Paroxetine Treatment

Year 2015, , 12 - 17, 08.10.2015

Birmay Çam

https://doi.org/10.17826/cutf.38000

Abstract

Antidepressant-induced mania has been reported with all major antidepressant classes in a subgroup of about 20-40% of bipolar patients. Mania/hypomania due to antidepressant withdrawal is rarely reported in the literature as case report. Mania/hypomania due to antidepressant withdrawal is reported to be associated with tricyclic antidepressants as well as selective serotonin reuptake inhibitors. This article offered mania occurring after discontinuation of treatment with paroxetine male patient. Mania associated with antidepressant discontinuation of the differential diagnosis, possible mechanisms, and the treatment has been discussed in the literature. Clinicians should be cautious mania/hypomania associated with antidepressant withdrawal. To do follow-up studies and case reports will help to clarify this table.

Keywords

Antidepressant discontinuation, hypomania, mania, paroxetine

Olası Paroksetin Tedavisinin Kesilmesi İle İlişkili İlk Atak Mani

Abstract

Antidepresan ilaç kullanan duygudurum bozukluğu olan hastalarda hipomanik/manik kayma riskinin %20-40 arasında olduğu bildirilmektedir. Antidepresan ilaçların azaltılması yada kesilmesi ile ortaya çıkan hipomani/mani ise olgu sunumlarıyla sınırlıdır. Daha çok trisiklik antidepresanların kesilmesi ile ortaya çıkmakla beraber seçici serotonin geri alım inhibitörlerinin kesilmesi ile de bildirilmiştir. Bu yazıda paroksetin tedavisinin kesilmesini takiben mani tablosu ortaya çıkan erkek hasta sunulmuş, antidepresan kesilmesi ile ortaya çıkan maninin ayırıcı tanısı, olası mekanizmaları, tedavisi literatür ışığında tartışılmıştır. Klinisyenler antidepresan kesimi ile ilişkili mani/hipomani açısından dikkatli olmalıdır. Bu alanda yapılacak izlem çalışmaları ve olgu bildirimleri bu tablonun aydınlatılmasına yardımcı olacaktır.

Keywords

Antidepresan kesilmesi, mani, hipomani, paroksetin

References

• Goldberg JF, Truman CJ. Antidepressant-induced mania: an overview of current controversies. Bipolar Disord. 2003;5:407-20.
• Kora K, Kaplan P. Antidepresan İlaç Kesimi İle
• Tetiklenen Hipomanik/Manik Kayma. Türk Psikiyatri Dergisi 2008;19:329-33.
• Calabrese JR, Rapport DJ, Kimmel SE, Shelton MD. Controlled trials in bipolar I depression: Focus on switch rates and efficacy. Eur Neuropsychopharmacol. 1999;9:109-12.
• Altıntoprak AE,Önen Sertöz Ö, Çoşkunol H.
• Antidepresan Kesilmesinin Neden Olduğu Mani: Bir Olgu ve Literatürün Gözden Geçirilmesi. Klinik Psikofarmakoloji Bülteni. 2006;16:245-51.
• Goldstein TR, Frye MA, Denicoff KD, Smith-Jackson E, Leverich GS, Bryan Al, Ali O, Post R. Antidepressant-discontinuation-related mania: critical prospective observation and theoretical implications in bipolar disorder. J Clin Psychiatry. 1999;60:563-7.
• Fava GA, Mangelli L. Mania associated with venlafaxine discontinuation. Int J Pharmacol. 1996;42:757-63. Neuropsychopharmacol. 2003;6:89-90.
• Andrade C. Antidepressant-withdrawal mania: a critical review and synthesis of the literature. J Clin Psychiatry 2004;65:987-93.
• Michael N, Erfurth A, Arolt V. A case report of mania related to discontinuation of bupropion therapy for smoking cessation. J Clin Psychiatry. 2004;65:277.
• Shriver AE, Sachs GS, Baldassano CF. Mania and hypomania following antidepressant discontinuation. In: New Research Program and abstracts of the 151st Annual Meeting of the American Psychiatric Association Toronto-Canada, Abstract Book 1998; abstract no: 161.
• Ali S, Milev R. Switch to mania upon discontinuation of antidepressants in patients with mood disorders: a review of the literature. Can J Psychiatry. 2003;48:258-64.
• Amerikan Psikiyatri Birliği. Mental Bozuklukların Tanısal ve Sayımsal El Kitabı. Dördüncü Baskı. Köroğlu E, çev editörü. Ankara: Hekimler Yayın Birliği, 1994..
• Akdemir A, Örsel S, Dağ İ, Türkçapar H, İşcan N, Özbay H. Hamilton Depresyon Derecelendirme Ölçeği (HDDÖ)’nin Geçerliği, Güvenirliği ve Klinikte Kullanımı. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 1996;4:251-9.
• Karadağ F, Oral ET, Aran Yalçın F, Eren E. Young Mani Derecelendirme Ölçeğinin Türkiye’de geçerlilik ve güvenilirliği. Türk Psikiyatri Derg. 2001;13:107-14.
• Guduk M, Yeser Erensoy I, Ersumer F. Mania/Hypomania Associated with Withdrawal of Antidepressants. Düşünen Adam The Journal of Psychiatry and Neurological Sciences, 2013;26:303- 6.
• Altshuler LL, Post RM, Leverich GS, Mikalauskas K, Rosoff A, Ackerman L. Antidepressant induced mania and cycle acceleration: a contoversy revisited. Am J Psychiatry. 1995;152:1130-8.
• Price JS, Waller PC, Wood SM, Mackay AV. A comparison of post-marketing safety of four selective re-uptake inhibitors including the investigation of symptoms occuring on withdrawal. Br J Clin
• Ghadirian AM. Paradoxical mood response following antidepressant withdrawal. Biol Psychiatry. 1986;21:1298-1300.
• Dilsaver SC, Greden JF. Antidepressant withdrawal- induced activation (hypomania and mania): mechanism and theoretical significance. Brain Res. 1984;7:29-48.
• Corral M, Sivertz K, Jones BD. Transient mood elevation associated with antidepressant drug decrease. Can J Psychiatry. 1987;32:764-7.
• Zajecka J, Tracy KA, Mitchell S. Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a literature review. J Clin Psychiatry. 1997;58:291-7.
• Charney DS, Heninger GR, Sternberg DE, Landis H. Abrupt discontinuation of tricyclic antidepressant drugs: evidence for noradrenergic hyperactivity. Br J Psychiatry. 1982;141:377-86.
• McGrath PJ, Stewart JW, Tricamo E, Nunes EN, Quitkin FM. Paradoxical mood shifts to euthymia upon withdrawal of antidepressant agents. J Clin Psychopharmacol. 1993;13:224-5.
• Rothschild AJ. Mania after withdrawal of isocarboxazid. J Clin Psychopharmacol. 1985;5:340- 2.
• Akiskal HS, Hantouche EG, Allilaire JF, Sechter D, Bourgeois ML, Azorin JM, Chatenêt-Duchêne L, Lancrenon S. Validating antidepressant associated hypomania (bipolar III): a systematic comparison with spontaneous hypomania (bipolar II). J Affect Disord. 2003;73:65–74.
• Aydemir Ö. İkincil Mani. Duygudurum Dizisi. 2001;5:234-40.
• Amerikan Psikiyatri Birliği. Ruhsal Bozuklukların Tanısal ve Sayımsal El Kitabı, Beşinci Baskı. Köroğlu E, çev editörü. Ankara: Hekimler Yayın Birliği, 2013.