N-3 çoklu doymamış yağ asitleri alımı ve depresyon üzerine etkileri: güncel literatür ne öneriyor?

Şeyma Kalkuz; Reyhan Nergiz Ünal

doi:10.17826/cumj.780923

TR EN

N-3 çoklu doymamış yağ asitleri alımı ve depresyon üzerine etkileri: güncel literatür ne öneriyor?

Öz

Günümüzde depresyon, sebepleri anlaşılmaya çalışılan ve tedavi yöntemleri üzerine pek çok araştırma yapılan güncel bir konu haline gelmiştir. Yapılan çalışmalara göre hem bireysel hem de toplumsal boyutta önemli bir halk sağlığı problemi haline gelmeye başlayan bu soruna, diyetteki n-3 çoklu doymamış yağ asitlerinin etkisinin irdelenmesi önemlidir. Depresyon tedavisinde n-3 çoklu doymamış yağ asitlerinin rolleri, son on yılda yaygınlaşan depresyon tanısı nedeniyle artan hızda çalışılmaktadır. Depresyon tedavisinde n-3 çoklu doymamış yağ asitlerinin anti-inflamatuar etkiler göstererek, membran akışkanlığını arttırarak, nörotransmitter geçişini değiştirerek, hipotalamus-hipofiz-adrenal aksın aktivitesini ve nörotrofik faktörlerin seviyelerini etkileyerek ve nöroplastisiteyi arttırarak etkili olabileceği birçok çalışmada bildirilmiştir. Bireye özel uygun miktarlarda n-3 çoklu doymamış yağ asitleri kulanımı ile ilişkili bir yan etkinin henüz belirlenmemiş olması nedeniyle daha fazla araştırma yapılmaktadır. Birçok çalışma tarafından n-3 çoklu doymamış yağ asitlerinin etkinliği kanıtlanmış olsa da, ‘ayrı ayrı ya da birlikte kullanımları’ ve ‘depresyon tedavisinde tek başına, alternatif tedavi yöntemi olarak kullanılabilirliği’ konuları hala tartışmalıdır.

Anahtar Kelimeler

Depresyon , yağ asitleri , omega-3 , balık yağları , lipidler

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Review

Authors

Şeyma Kalkuz
0000-0001-9769-5707
Türkiye

Reyhan Nergiz Ünal ^*
0000-0002-3143-7710
Türkiye

Publication Date

December 27, 2020

Submission Date

August 17, 2020

Acceptance Date

October 15, 2020

Published in Issue

Year 2020 Volume: 45 Number: 4

DOI

https://doi.org/10.17826/cumj.780923

IZ

https://izlik.org/JA36KL57KB

MLA

Kalkuz, Şeyma, and Reyhan Nergiz Ünal. “N-3 çoklu Doymamış Yağ Asitleri Alımı Ve Depresyon üzerine Etkileri: Güncel Literatür Ne öneriyor?”. Cukurova Medical Journal, vol. 45, no. 4, Dec. 2020, pp. 1803-17, doi:10.17826/cumj.780923.

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

N-3 çoklu doymamış yağ asitleri alımı ve depresyon üzerine etkileri: güncel literatür ne öneriyor?

N-3 çoklu doymamış yağ asitleri alımı ve depresyon üzerine etkileri: güncel literatür ne öneriyor?

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Anahtar Kelimeler

N-3 polyunsaturated fatty acids intake and effects on depression: what is suggested by the current literature?

Abstract

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