Thiol/disülfid homeostazının kronik obstrüktif akciğer hastalığı ile ilişkili mortalitedeki etkisi

Year 2021, , 566 - 573, 30.06.2021

Hacı Mehmet Çalışkan , Bilal İlanbey , Duygu Zorlu , Zamir Ertürk , Burak Çelik , Süleyman Ersoy

https://doi.org/10.17826/cumj.852885

Abstract

Amaç: Bu çalışmada Hiperkapnik solunum yetmezliği (HSY) olan kronik obstrüktif akciğer hastalarındaki mortalite (KOAH) ile thiol/disülfid homeostazisi arasındaki ilişki araştırılmıştır.
Gereç ve Yöntem: Bu kesitsel prospektif çalışma, solunum yetmezliği nedeniyle acil servise başvuran 64 hiperkapnik solunum yetmezliği (HSY) hastası ve 40 sağlıklı kontrol dahil olmak üzere toplam 104 kişiden oluşmaktadır. HRF hastaları ayrıca 1 ay sonra mortalite meydana gelenler (n = 14) ve hayatta kalanlar olarak iki alt gruba ayrıldı. Thiol/Disülfid homeostazı, Erel ve Neselioğlu tarafından geliştirilen yeni ve otomatik bir ölçme yöntemi kullanılarak değerlendirildi.
Bulgular: Total thiol (TT) ve native thiol (NT) seviyeleri, HSY grubunda kontrol grubuna göre anlamlı derecede daha düşüktü, oysa ortalama disülfid (Ds)/ TT ve Ds / NT değerleri önemli ölçüde daha. Disülfid seviyelerinde ise guruplar arasında önemli bir fark yoktu. Ayrıca Hayatta kalan HRF hastalarının Ds, Ds / TT ve Ds / NT değerleri, ölen HRF hastalarınınkinden önemli ölçüde daha düşüktü. Biz bu makalede Disülfid’in KOAH'da mortalitenin bir göstergesi olabileceğini bulduk (duyarlılık:% 85.7, özgüllük:% 70, EAA: 0.793,% 95 CI: 0.673-0.884, p <0.001).
Sonuç: Tihiol/Disülfid parametreleri acil servislerde ve hastanelerde hiperkapnik solunum yetmezliği tanısında ve prognozun öngörülmesi ve iyileştirilmesinde kullanılabilir.

Keywords

Acil servis, hiperkapnik solunum yetmezliği, oksidatif stres, thiol

Supporting Institution

Yok

Project Number

Proje değil

Thanks

Dr Yusuf Dursun'a katkılarından dolayı teşekkür ediyoruz

The effect of thiol/disulfide homeostasis on chronic obstructive pulmonary disease-related mortality

Abstract

Purpose: Our study investigates the correlation between thiol/disulfide homeostasis and mortality among chronic obstructive pulmonary disease (COPD) patients with hypercapnic respiratory failure (HRF).
Materials and Methods: This cross-sectional prospective study comprises a total of 104 subjects, including 64 HRF patients admitted to the Emergency service due to respiratory failure and 40 healthy controls. HRF patients were further divided into two subgroups as those in whom mortality occured after 1 month (n=14), and those who survied (n=50). Thiol/disulfide homeostasis was evaluated using a novel and automated assay developed by Erel and Neselioglu.
Results: The total thiol (TT) and native thiol (NT) levels were significantly lower in the HRF group than the control group, whereas the mean disulfide (Ds)/TT and Ds/NT values were significantly higher. The Ds levels were not significantly different between the groups. On the other hand, Ds, Ds/TT, and Ds/NT values of surviving HRF patients were significantly lower than those of the HRF patients who died. In this article we found that Ds may be an indicator of mortality in COPD (sensitivity: 85.7%, specificity: 70%, AUC: 0.793, 95% CI: 0.673-0.884, p<0.001).
Conclusion: Thiol/disulfide parameters may be used in emergency service and hospitals in the diagnosis of HRF, and for the prediction and improvement of prognosis.

Keywords

Emergency service, hypercapnic respiratory failure, oxidative stress, thiol

Project Number

Proje değil

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