Which hemogram-derived indices might be useful in predicting the clinical outcomes of sepsis patients in the intensive care unit?

Esra Çakır; Işıl Özkoçak Turan

doi:10.17826/cumj.856741

EN TR

Which hemogram-derived indices might be useful in predicting the clinical outcomes of sepsis patients in the intensive care unit?

Abstract

Purpose: The aim of our study is to investigate the prognostic value of Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in determining mortality in patients hospitalized for intensive care unit (ICU) sepsis. Materials and Methods: This study retrospectively evaluates all patients hospitalized with sepsis in our ICU between February 2017 and April 2018. In addition to the demographic and clinical characteristics of the patients, complete blood count parameters were also recorded. Demographic and clinical characteristics, mainly NLR, MLR and PLR results, and other laboratory results of patients with sepsis were compared between the ones with and without mortality. Results: Four hundred and eleven patients were included in the study. 55.7% (229/411) of patients with sepsis died and 44.3% (182/411) were discharged alive. NLR, MLR and PLR were higher in the group with mortality compared to the survivor group. The cut-off value for predicting mortality in patients with sepsis was 9.2 for NLR, ≥0.8 for MLR, and ≥187.3 for PLR. The area under the curve (AUC) value for NLR was 0.825, the AUC value for MLR 0.835 and the AUC value for PLR was 0.720. Conclusion: High NLR, MLR and PLR values are associated with mortality in sepsis patients hospitalized in ICU, and the most significant parameter for mortality indicator among the three rates was found to be MLR with the highest AUC value.

Keywords

neutrophil-to-lymphocyte ratio , monocyte-to-lymphocyte ratio , platelet-to lymphocyte ratio , sepsis , intensive care unit

Yoğun bakım ünitesindeki sepsis hastalarının klinik sonuçlarını tahmin etmede hangi hemogramdan türetilmiş indeksler yararlı olabilir?

Öz

Amaç: Çalışmamızın amacı, yoğun bakım ünitesinde (YBÜ) sepsis nedeniyle yatan hastalarda nötrofil lenfosit oranı (NLO), monosit lenfosit oranı (MLO) ve trombosit lenfosit oranı (TLO mortaliteyi belirlemedeki prognostik değerini araştırmaktır. Gereç ve Yöntem: Çalışmamızda, Şubat 2017 – Nisan 2018 tarihleri arasında YBÜ’de yatan tüm sepsisli hastalar retrospektif olarak değerlendirilmiştir. Hastaların demografik ve klinik özelliklerine ek olarak tam kan sayımı parametreleri kayıt edildi. Mortalite olan ve olmayan sepsisli hastaların başlıca NLO, MLO ve TLO sonuçları olmak üzere demografik ve klinik özellikleri ile diğer laboratuvar sonuçları karşılaştırıldı. Bulgular: Çalışmaya 411 hasta dahil edildi. Sepsisli hastaların %55,7’si (229/411) öldü ve %44,3 hasta (182/411) sağ taburcu edildi. Mortalite olan grupta yaşayan gruba göre NLO, MLO ve TLO daha yüksek bulundu. Sepsisli hastalarda mortalite tahmini için eşik NLO için ≥9,2, MLO için ≥0,8, TLO için ≥187,3 olarak bulundu. Nötrofil lenfosit oranı için eğri altında kalan alana (AUC) değeri 0,825, MLO için AUC değeri 0,835 ve TLO için AUC değeri 0,720 olarak bulundu. Sonuç: Yoğun bakım ünitesinde yatan sepsis hastalarında yüksek NLO, MLO ve TLO değerleri mortalite ile ilişkili olup, üç oran arasından mortalite göstergesi için en anlamlı parametre AUC değeri en yüksek olan MLO olarak bulundu.

Anahtar Kelimeler

Nötrofil lenfosit oranı , monosit lenfosit oranı , trombosit lenfosit oranı , sepsis , yoğun bakım ünitesi , mortalite

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Details

Primary Language

English

Subjects

Intensive Care

Journal Section

Research Article

Authors

Esra Çakır ^*
0000-0002-6992-5744
Türkiye

Işıl Özkoçak Turan
0000-0002-0405-0107
Türkiye

Publication Date

June 30, 2021

Submission Date

January 8, 2021

Acceptance Date

February 26, 2021

Published in Issue

Year 1970 Volume: 46 Number: 2

DOI

https://doi.org/10.17826/cumj.856741

IZ

https://izlik.org/JA32AG23SR

MLA

Çakır, Esra, and Işıl Özkoçak Turan. “Which Hemogram-Derived Indices Might Be Useful in Predicting the Clinical Outcomes of Sepsis Patients in the Intensive Care Unit?”. Cukurova Medical Journal, vol. 46, no. 2, June 2021, pp. 532-9, doi:10.17826/cumj.856741.

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This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Which hemogram-derived indices might be useful in predicting the clinical outcomes of sepsis patients in the intensive care unit?

Which hemogram-derived indices might be useful in predicting the clinical outcomes of sepsis patients in the intensive care unit?

Abstract

Keywords

Yoğun bakım ünitesindeki sepsis hastalarının klinik sonuçlarını tahmin etmede hangi hemogramdan türetilmiş indeksler yararlı olabilir?

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Diagnostic Role of Systemic Inflammatory Indices in Infants with Moderate-to-Severe Hypoxic Ischemic Encephalopathy

Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis

Role of Systemic Inflammatory Indices in the Prediction of Moderate to Severe Bronchopulmonary Dysplasia in Preterm Infants

Evaluation of the Effectiveness of Systemic Inflammatory Indices in the Diagnosis of Respiratory Distress Syndrome in Preterm with Gestational Age of ≤32 Weeks

Evaluation of the efficacy of systemic inflammatory indices in determining mortality in very low birth weight infants

Effect of sex and mode of delivery on systemic inflammatory indices in preterm infants

Evaluation of systemic inflammatory indices in the diagnosis of early onset neonatal sepsis in very low birth weight infants

How does being a twin premature infant affect systemic inflammatory indices?

Systemic Inflammatory Indices as Predictors of Lung Maturation in Preterm Infants Born Before 32 Weeks of Gestation

Índices Inflamatórios Sistêmicos como Novos Biomarcadores para Canal Arterial Hemodinamicamente Significativo

Systemic Inflammatory Indices as New Biomarkers for Hemodynamically Significant Ductus Arteriosus

The Relationship Between Inflammatory Markers and Supraventricular Tachycardia in Children

Complete blood count (CBC)-derived indices at admission and short-term outcomes in ICU patients: a retrospective study

Prognostic Value of Initial Inflammatory Biomarkers, ECG Findings, and Computed Tomography in the Assessment of Acute Pulmonary Embolism Severity