Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital

Year 2021, , 601 - 609, 30.06.2021

Emine Nur Özdamar , İhsan Özdamar

https://doi.org/10.17826/cumj.865824

Abstract

Purpose: The aim of the present study is to determine the frequency and severity of possible drug-drug interactions (DDIs) in the prescriptions of patients who admitted to the orthopedics and traumatology outpatient clinics.
Materials and Methods: This cross-sectional, retrospective study analyzed the prescription data of patients that admitted to orthopedics and traumatology outpatient clinics of a tertiary care hospital from January 1, 2020 to February 15, 2020. The severity of DDIs was interpreted using the Lexi-comp® drug interaction database. Relationship between the presence of DDIs and the number of prescribed drugs were evaluated.
Results: Out of 753 patient data evaluated, a total of 2248 drugs were prescribed. Among 669 polypharmacy patients, 293 (43.8%) patients had one or more potential DDIs. A total of 437 DDIs were detected of which 300 (68.6%) were D, 82 (18.8%) were X, 49 (11.2%) were C and 6 (1.4%) were B risk category interactions. The most common DDIs were between systemic Diclofenac and topical Diclofenac, (14.4%) The presence of potential DDIs was significantly associated with adult age and female gender.
Conclusion: Although, the severity of the potential DDIs in orthopedics and traumatology outpatient clinics were generally moderate and manageable, it is crutial for physicians to be aware of the interactions between the most frequently prescribed drugs in orthopedics and traumatology outpatient clinics, monitor patients for the safe use of drugs.

Keywords

Drug interactions, polypharmacy, orthopedics

Üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin değerlendirilmesi

Abstract

Amaç: Bu çalışmanın amacı, ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçetelerinde olası ilaç-ilaç etkileşimlerinin sıklığını ve şiddetini belirlemektir.
Gereç ve Yöntem: Bu kesitsel retrospektif çalışma, 1 Ocak 2020- 15 Şubat 2020 tarihleri arasında üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçete verilerini analiz etti. İlaç-ilaç etkileşimlerinin şiddeti, Lexi-comp® ilaç etkileşimi veri tabanı kullanılarak yorumlandı. İlaç-ilaç etkileşimi varlığı ile reçetelenmiş ilaç sayısı arasındaki ilişki değerlendirildi.
Bulgular: Değerlendirilen 753 hasta verisinde toplam 2248 ilaç reçete edildi. 669 polifarmasi hastasından, 293 (%43.8) hastanın bir veya daha fazla potansiyel ilaç- ilaç etkileşimi vardı. 300’ü (%68.6) D, 82’si (%18.8) X, 49’u (%11.2) C ve 6’sı (%1.4) B risk kategorisi etkileşimleri olmak üzere toplam 437 ilaç-ilaç etkileşimi tespit edildi. En sık ilaç- ilaç etkileşimleri sistemik diklofenak ve topical diklofenak arasındaydı (%14.4). Olası ilaç-ilaç etkileşimlerinin varlığı erişkin yaş ve kadın cinsiyet ile anlamlı olarak ilişkiliydi.
Sonuç: Ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin şiddeti genel olarak orta düzeyde ve yönetilebilir olsa da, ortopedi ve travmatoloji polikliniklerinde en sık reçete edilen ilaçlar arasındaki etkileşimlerden haberdar olmak ve ilaçların güvenli kullanımı için hastaları izlemek hekimler açısından önem taşımaktadır.

Keywords

İlaç etkileşimleri, polifarmasi, ortopedi

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