Association between synovial fluid prostanoid levels and ultrasonographic findings in knee osteoarthritis

Gülsev Özen; Ekin İlke Şen; Zeynep Çelik; Tuğba Şahbaz; Gökçe Topal; Demirhan Dıraçoğlu

doi:10.17826/cumj.899751

TR EN

Diz osteoartriti bulunan hastalarda sinoviyal sıvılarındaki prostanoid düzeyleri ve ultrasonografik bulgular arasındaki ilişki

Öz

Amaç: Bu çalışmada, diz osteoartriti olan hastaların sinoviyal sıvılarındaki prostanoidlerin [tromboksan (TxA2) ve prostasiklin (PGI2)] düzeyi ile infrapatellar ve suprapatellar yağ yastığı kalınlığı ve diğer klinik parametreler arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya efüzyonlu diz osteoartriti bulunan 16 hasta dahil edilmiştir. Ağrı düzeyleri görsel analog skala (VAS) ile değerlendirilmiştir. Ağrı, sertlik ve fiziksel fonksiyon osteoartrit indeksi (WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index) ile değerlendirilmiştir. PGI2’nin kararlı metaboliti olan 6-keto-PGF1α ve TxA2’nin kararlı metaboliti olan TxB2 düzeyleri enzim immunoassay yöntemi ile ölçülmüştür. Bulgular: Sinoviyal sıvıda ölçülen 6-keto-PGF1α düzeyleri TxB2 düzeylerine göre anlamlı derecede yüksek bulunmuştur. TxB2 düzeyleri ile suprapatellar yağ yastığı kalınlığı ve TxB2/6-keto- PGF1α oranı ile kıkırdak kalınlığı arasında negatif korelasyon bulunmaktadır. Infrapatellar yağ yastığı kalınlığı ile suprapatellar yağ yastığı kalınlığı ve efüzyon hacmi arasında pozitif korelasyon bulunmaktadır. WOMAC değerleri ile VAS-aktivite ve VAS-gece skorları arasında pozitif korelasyon bulunmaktadır. Sonuç: 6-keto-PGF1α düzeylerine kıyasla, sinoviyal sıvı TxB2 düzeyleri osteoartritli hastalardaki ultrasonografik bulgular ile daha çok ilişkili bulunmuştur.

Anahtar Kelimeler

infrapatellar yağ yastığı , PGI2 , TxA2 , osteoartrit , suprapatellar yağ yastığı

Association between synovial fluid prostanoid levels and ultrasonographic findings in knee osteoarthritis

Abstract

Purpose. The aim of this study was to investigate the association between prostanoid [thromboxane (TxA2) and prostacyclin (PGI2)] levels in synovial fluid and infrapatellar fat pad (IPFP)/ suprapatellar fat pad (SPFP) thickness as well as other clinical findings in knee steoarthritis (OA) patients. Materials and Methods: 16 patients with knee OA with effusion were included. The average pain levels were evaluated using a Visual Analogue Scale (VAS). The pain, stiffness, and physical functions were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The levels of 6-keto-PGF1α, stable metabolite of PGI2, and TxB2, stable metabolite of TxA2, were measured in synovial fluid using an enzyme immunoassay. Results: 6-keto-PGF1α levels were significantly greater than TxB2 levels in synovial fluid of patients with OA. TxB2 levels and TxB2/6-keto- PGF1α ratio were negatively correlated with SPFP and cartilage thickness, respectively. IPFP thickness was positively correlated with SPFP thickness and effusion volume. WOMAC scores were positively correlated with VAS-activity and VAC-evening scores. Conclusion: In comparison to 6-keto- PGF1α levels in synovial fluid, TxB2 levels seem to be more associated with ultrasonographic findings in patients with OA.

Keywords

Prostacyclin , thromboxane A2 , fat pads , cartilage , knee osteoarthritis

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Gülsev Özen ^*
0000-0002-8862-383X
Türkiye

Ekin İlke Şen This is me
0000-0002-6489-3368
Türkiye

Zeynep Çelik This is me
0000-0002-4540-1671
Türkiye

Tuğba Şahbaz
0000-0003-2566-0630
Türkiye

Gökçe Topal
0000-0001-7196-3179
Türkiye

Demirhan Dıraçoğlu This is me
0000-0003-3182-0127
Türkiye

Publication Date

September 30, 2021

Submission Date

March 25, 2021

Acceptance Date

June 10, 2021

Published in Issue

Year 2021 Volume: 46 Number: 3

DOI

https://doi.org/10.17826/cumj.899751

IZ

https://izlik.org/JA65NJ73JG

MLA

Özen, Gülsev, et al. “Association Between Synovial Fluid Prostanoid Levels and Ultrasonographic Findings in Knee Osteoarthritis”. Cukurova Medical Journal, vol. 46, no. 3, Sept. 2021, pp. 934-43, doi:10.17826/cumj.899751.

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Diz osteoartriti bulunan hastalarda sinoviyal sıvılarındaki prostanoid düzeyleri ve ultrasonografik bulgular arasındaki ilişki

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Association between synovial fluid prostanoid levels and ultrasonographic findings in knee osteoarthritis

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