Genç inmeli hastalarda trombofili durumunun kısa dönem sonlanım ile ilişkisi

Year 2021, , 1125 - 1131, 30.09.2021

Cihat Uzunköprü , Esra Başkurt Tea Beqiroski

https://doi.org/10.17826/cumj.913583

Abstract

Amaç: İskemik inme genç kişilerde ciddi sağlık sorunlarına yol açan bir durumdur. Bu çalışmada da genç iskemik inmeli hastalarda trombofili polimorfizmlerinin iskemik inme ve diğer risk faktörleri ile ilişkisi incelenmiştir.
Gereç ve Yöntem: Çalışmaya 50 yaş altında toplam 64 adet iskemik inme geçiren hasta dahil edildi. Hastaların Bilgisayarlı Tomografi Anjiografi, Holter Elektrokardiografi, Transtorasik Ekokardiyografi, trombofili durumları ile baseline ve 1. ay Modifiye Rankin Skalaları kayıt altına alındı. Hastaların trombofili durumları ile kısa dönem iyilik hali arasındaki ilişki değerlendirilmiştir.
Bulgular: Çalışmamıza 64 hasta (38 erkek, % 59.4) dahil edildi. Hastaların ortalama yaşı 42,48 ± 6,73 idi. En sık görülen polimorfizm MTHFRA1298T mutasyonu (% 18.8 homozigot, % 43.7 heterozigot) idi. İkinci sıklıkta MTHFRC677T mutasyonu ve üçüncü olarak da Faktör 5 Leiden mutasyonu (% 21.8 homozigot ve % 34.4 heterozigot) gözlendi. Hastaların % 7,8'inde atriyal fibrilasyon, % 17,2'sinde patent foramen ovale ve % 7,8'inde artmış pulmoner arter basıncı (> 30 mmHg) izlendi. Genç yetişkinlerde trombofili varlığı ve PFO’nun iskemik inme ile ilişkisi saptanmadı.
Sonuç: Genç inmeli hastalarda birçok trombofili polimorfizmi mevcuttur ancak iskemik inme ile ilişkisi saptanmamıştır. Bu hastalarda iskemik inme ile ilişkili birçok klasik risk faktörü tespit edilmiş olup uygun şekilde tedavi edilmelidir. Diğer önemli bir faktör de patent foramen ovale varlığı olup iskemik inme ile ilişkisinin değerlendirilmesi için daha fazla çalışmaya ihtiyaç vardır.

Keywords

iskemik inme, trombofili, patent foramen ovale, atriyal fibrilasyon

Supporting Institution

Yok

Relationship between thrombophilia status and short-term outcome in young adults with ischemic stroke

Abstract

Purpose: Ischemic stroke is a serious health condition in patients with young adults. This study aims to determine thrombophilia polymorphisms in young patients with ischemic stroke and associations with other risk factors.
Materials and Methods: We evaluated 64 patients with ischemic stroke under 50 years old. Computerized Tomography Angiography, Holter Electrocardiography, Transthoracic Echocardiography, thrombophilia status, and Modifying Rankin Scale (MRS) in baseline and first month findings were recorded. We analysed the association between thrombophilia status and short-term outcome in young adults with ischemic stroke.
Results: 64 patients (38 male, 59.4%) were included in our study. The mean age of the patients were 42.486.73. The thrombophilia status showed that the most frequent polymorphism was MTHFRA1298T mutation (18.8% homozygous, 43.7% heterozygous). The second was MTHFRC677T and the third polymorphism was Factor 5 Leiden mutation, of 21.8% was homozygous and 34.4% was heterozygous mutation. 7.8% of the patients have atrial fibrillation, 17.2% of them have patent foramen ovale, and 7.8% have elevated pulmonary artery pressure (>30 mmHg). Thrombophilia status and PFO were not associated with IS in young adults.
Conclusion: Young patients with ischemic stroke have several thrombophilial polymorphism; however, we did not detect any association with IS. Young patients with ischemic stroke have also many classic risk factors which should be treated appropriately. Patent foramen ovale is another remarkable pathology and more researches are needed to realize its relation with ischemic stroke in young adults.

Keywords

Ischemic stroke, thrombophilia, atrial fibrillation, patent foramen ovale

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