Alkol ve madde kullanım bozukluğu tanılı hastalarda inflamasyon düzeyleri

Year 2021, , 1558 - 1565, 30.12.2021

Müberra Kulu , Filiz Özsoy , Bahadır Demir

https://doi.org/10.17826/cumj.975848

Cited By: 4

Abstract

Amaç: Bu çalışmada amaç; alkol kullanım bozukluğu (AKB) ve madde kullanım bozukluğu (MKB) tanısı konulan iki ayrı hasta grubunun inflamasyon belirteçlerini sağlıklı kontroller ve birbirleri ile karşılaştırarak incelemektir.
Gereç ve Yöntem: Çalışmamıza 159 kişi (100 kişi hasta grubu ve 59 kişi kontrol grubu olarak) alındı. Tüm katılımcıların demografik verileri bir form halinde yazıldı ve laboratuvar parametreleri tam kan sayımı ile değerlendirildi.
Bulgular: MKB tanılı hastaların; 24’ü (%48) esrar, 26’sı (%52) sentetik kannabinoid kullanıyordu. Her iki hasta grubunda da hemoglobin, hematokrit, RDW-standart sapma olarak değeri (RDW-SD), ortalama platelet hacmi (MPV) değeri sağlıklı kontrollerden yüksek idi. Platelet değeri AKB hastalarında diğer iki gruptan düşük iken, eritrosit değeri MKB hastalarında diğer iki gruptan yüksek idi.
Sonuç: Hem AMKB patofizyolojisinde bazı inflamatuvar parametrelerinin etkili olabileceği düşünülmüştür. Ayrıca bu parametrelerdeki değişikliklere bağlı olarak oluşabilecek spontan kanama, enfeksiyon hastalıklarına yatkınlık gibi komplikasyonlar da hem hastaların değerlendirilmeleri hem de tedavi planlamalarında göz önüne alınmalıdır.

Keywords

Alkol kullanım bozukluğu, esrar, sentetik kannabinoid, inflamasyon, nötrofil/lenfosit oranları, platelet/lenfosit oranları, monosit lenfosit oranı.

Supporting Institution

Yoktur

Project Number

-

Inflammation levels in patients with alcohol and substance use disorders

Abstract

Purpose: The aim of this study was to analyse the inflammation indicators of two patients, which were diagnosed with alcohol use disorder(AUD), and substance use disorder(SUD), with each other as well as with the healthy control group.
Materials and Methods: A group of 159 people (100 patient, 59 healthy control) have been included in the study. All participants have been applied a demographical data form and laboratory parameters have been evaluated with complete blood cell count.
Results: Among the patients diagnosed with SUD, 24 (%48) cannabis while 26 (%52) used synthetic cannabinoid. In both patient groups the values of haemoglobin, haematocrit, RDW-standard deviation value (RDW-SD), main platelet volume (MPV) was tested to be higher than that of the healthy control groups. While the platelet value of AUD patients was lower than the two other groups, erythrocyte value of SUD patients was higher than the two other groups.
Conclusion: Some inflammatory parameters could affect ASUD pathophysiology. In addition, complications such as spontaneous bleeding and susceptibility to infectious diseases that may occur due to changes in these parameters should be kept in mind during both in treatment planning and the development of symptoms.

Keywords

Alcohol use disorder, cannabis, synthetic cannabinoid, inflammation

Project Number

-

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