C-reactive protein to albumin ratio is associated with increased risk of mortality in COVID-19 pneumonia patients

Selen Acehan; Müge Gülen; Cem Isikber; Adem Kaya; Nurdan Unlu; Cagdas Ince; Basak Toptas Firat; Gonca Koksaldı; Hilmi Erdem Sümbül; Salim Satar

doi:10.17826/cumj.977050

TR EN

C-reaktif protein/albümin oranı COVID-19 pnömonisi olan hastalarda artan mortalite riski ile ilişkilidir

Öz

Amaç: Bu retrospektif gözlemsel çalışmanın amacı, COVID-19 pnömonisi nedeniyle hastaneye yatırılan 18 yaş üstü hastalarda mortaliteyi öngörme açısından acil serviste bakılan C-reaktif protein/albumin oranı ile CURB-65 skorunun karşılaştırılmasıdır. Gereç ve Yöntem: Çalışma 15 Mart-30 Nisan 2020 tarihleri arasında acil servis pandemi alanında toraks bilgisayarlı tomografisinde COVID-19 pnömonisi tespit edilerek hastaneye yatırılan 613 hastayı kapsamaktadır. Hastanede yatan hastalar pozitif ve negatif gerçek zamanlı polimeraz zincir reaksiyonu sonuçlarına göre gruplara ayrıldı. Bulgular: Çalışmaya dahil edilen 613 hastanın %73,1'i (n:448) serviste yatarken, %26,9'u (n:165) yoğun bakımda yatmaktaydı. Toplam hastaların %8,6'sı (n:53) öldü. Ölen hastalarda CURB 65 skoru ortalama 4±1 ve C-reaktif protein/albümin oranı 5.6±4.2 idi.. Çok değişkenli lojistik regresyon analizi, CURB 65 skorunu) ve yüksek C-reaktif protein/albümin oranı olduğunu gösterdi.) COVID-19 pnömonisi için bağımsız risk faktörleri olarak göstermiştir. Sonuç: C-reaktif protein/albumin oranı, kötü prognozlu COVID-19 pnömonisi olan hastaların erken tespitinde CURB 65 kadar duyarlı olup klinisyene yol gösterebilir.

Anahtar Kelimeler

Acil Servis , CRP/Albümin Oranı , Covid-19 , CURB 65 , Pnömoni

C-reactive protein to albumin ratio is associated with increased risk of mortality in COVID-19 pneumonia patients

Abstract

Purpose: The aim of this retrospective observational study is to compare C-reactive protein to albumin ratio and CURB-65 score in the emergency department in terms of predicting mortality in patients over the age of 18 who were hospitalized for COVID-19 pneumonia. Materials and Methods: The study includes 613 patients hospitalized between March 15 and April 30, 2020 due to COVID-19 pneumonia detected on thorax computed tomography at the emergency department pandemic area. Hospitalized patients were divided into groups according to positive and negative real-time polymerase chain reaction results. Results: While 73.1% (n: 448) of 613 patients included in the study were hospitalized in the ward, 26.9% (n: 165) were hospitalized in intensive care. 8.6% (n: 53) of the total patients died. In non-survivors patients the mean CURB 65 score was 4±1 (and C-Reactive Protein to Albumin Ratio was 5.6±4.2 Multivariate logistic regression analysis showed that CURB 65 and high C-Reactive Protein to Albumin Ratio are independent risk factors for COVID-19 pneumonia. Conclusion: The C-reactive protein to albumin ratio is as sensitive as CURB 65 and can guide the clinician in the early detection of patients with poor prognosis COVID-19 pneumonia.

Keywords

CRP/Albumine Ratio , Covid-19 , CURB 65 , Emergency Department , Pneumonia

References

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Selen Acehan ^*
0000-0003-4390-6593
Türkiye

Müge Gülen
0000-0002-5080-3501
Türkiye

Cem Isikber
0000-0002-9904-0189
Türkiye

Adem Kaya
0000-0001-9529-1354
Türkiye

Nurdan Unlu This is me
0000-0002-0460-4472
Türkiye

Cagdas Ince This is me
0000-0002-5914-1460
Türkiye

Basak Toptas Firat
0000-0001-8327-8814
Türkiye

Gonca Koksaldı This is me
0000-0002-0550-3606
Türkiye

Hilmi Erdem Sümbül
0000-0002-7192-0280
Türkiye

Salim Satar
0000-0001-6080-4287
Türkiye

Publication Date

December 30, 2021

Submission Date

August 4, 2021

Acceptance Date

September 27, 2021

Published in Issue

Year 1970 Volume: 46 Number: 4

DOI

https://doi.org/10.17826/cumj.977050

IZ

https://izlik.org/JA85UJ86PR

MLA

Acehan, Selen, et al. “C-Reactive Protein to Albumin Ratio Is Associated With Increased Risk of Mortality in COVID-19 Pneumonia Patients”. Cukurova Medical Journal, vol. 46, no. 4, Dec. 2021, pp. 1449-58, doi:10.17826/cumj.977050.