Serum uric acid levels in borderline personality disorder and its relationship with impulsivity

Year 2021, , 1624 - 1631, 30.12.2021

Aslı Kazğan , Sevler Yıldız , Osman Kurt , Sevda Korkmaz

https://doi.org/10.17826/cumj.999393

Cited By: 1

Abstract

Purpose: The aim of this study is to investigate the serum uric acid levels in patients diagnosed with borderline personality disorder (BPD) who do not use drugs and explore their possible relationship with impulsivity.
Materials and Methods: Sixty-nine patients diagnosed with BPD and 54 healthy controls were enrolled in this study. All participants were administered a sociodemographic data form and the Barratt Impulsivity Scale Short Form (BIS-11). Subsequently, fasting venous blood samples were collected from all participants and serum uric acid levels were studied.
Results: It was found that serum uric acid levels, BDI-11 subdimension and total scores, and the BDI total score were significantly higher in patients diagnosed with BPD than in the control group. A significant positive correlation was seen between serum uric acid levels and the BDI-11 scale score.
Conclusion: This study report higher serum uric acid levels in patients diagnosed with borderline personality disorder who do not use drugs compared to the control group. The results of this study may provide an example that impulsivity in patients diagnosed with borderline personality disorder has a biological basis. Future longitudinal and experimental studies of uric acid levels in BPD patients will allow us an alternative way to diagnose and treat impulsivity in these patients.

Keywords

Borderline personality disorder, impulsivity, uric acid

Sınırda kişilik bozukluğunda serum ürik asit seviyeleri ve dürtüsellikle ilişkisi

Abstract

Amaç: Çalışmanın amacı ilaç kullanımı olmayan sınırda kişilik bozukluğu (SKB) tanılı hastalardaki serum ürik asit seviyelerini incelemek ve bunun dürtüsellikle olabilecek olası ilişkisini araştırmaktır.
Gereç ve Yöntem: Bu çalışmaya SKB tanılı 69 hasta ve 54 sağlıklı kontrol grubu dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Barratt Dürtüsellik Ölçeği Kısa Formu (BDÖ-11) uygulanmıştır. Ardından tüm katılımcılardan açlık venöz kan örnekleri alınarak serum ürik asit düzeyleri çalışılmıştır.
Bulgular: SKB tanılı hastalarda serum ürik asit seviyeleri, BDÖ-11 alt boyut ve toplam puanları ve BDÖ toplam puanı kontrol grubundan anlamlı şekilde yüksek bulunmuştur. Serum ürik asit seviyeleri ile BDÖ-11 ölçek puanı arasında pozitif yönde anlamlı bir korelasyon olduğu görülmüştür.
Sonuç: Bu çalışmada, ilaç kullanımı olmayan sınırda kişilik bozukluğu tanılı hastalarda kontrol grubuna göre daha yüksek serum ürik asit seviyelerini bildirilmiştir. Çalışmanın bulguları SKB tanılı hastalardaki dürtüselliğin biyolojik temellere dayandırılması açısından örnek oluşturabilir. SKB hastalarında ürik asit seviyeleri ile ilgili ileride yapılacak olan uzunlamasına ve deneysel çalışmalar bizlere bu hastalardaki dürtüselliğin tanı ve tedavisi açısından alternatif bir yol gösterecektir.

Keywords

dürtüsellik, kişilik bozukluğu, ürik asit

References

• 1. Links PS, Heslegrave R, van Reekum R. Impulsivity: core aspect of borderline personality disorder. J Pers Disord. 1999; 13:1-9. doı: 10.1521/pedi.1999.13.1.1.
• 2. Guerreiro S, Ponceau A, Toulorge D, Martin E, Alvarez-Fischer D, Hirsch EC, et al. Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: Potentiation by low-level depolarization. J Neurochem. 2009; 109(4): 1118–28. doi: 10.1111/j.1471-4159.2009.06040.x.
• 3. Weisskopf MG, O’Reilly E, Chen H, Schwarzschild MA, Ascherio A. Plasma urate and risk of Parkinson’s disease. Am J Epidemiol. 2007; 166: 561–7. doi:10.1093/aje/kwm127.
• 4. Albert U, De Cori D, Aguglia A, Barbaro F, Bogetto F, Maina G. Increased uric acid levels in bipolar disorder subjects during different phases of illness. J Affect Disord. 2015; 173: 170-5. doi: 10.1016/j.jad.2014.11.005. 5. Lorenzi TM, Borba D, Dutra G, Lara DR. Association of serum uric acid levels with emotional and affective temperaments. J Affect Disord. 2010; 121(1-2): 161-4. doi: 10.1016/j.jad.2009.05.023.
• 6. Salvadore G, Viale CI, Luckenbaugh DA, Zanatto VC, Portela LV, Souza DO, et al. Increased uric acid levels in drug-naive subjects with bipolar disorder during a first manic episode. Prog Neuro-Psychopharmacol Biol Psychiatry. 2010; 34(6): 819–21. doi:10.1016/j.pnpbp.2010.02.027
• 7. Sutin AR, Cutler RG, Camandola S, Uda M, Feldman NH, Cucca F, et al. Impulsivity is Associated with Uric Acid: Evidence from Humans and Mice. Bıol Psychıatry. 2014; 75: 31–7. doi.org/10.1016/j.biopsych.2013.02.024.
• 8. Manowitz P, Amorosa LF, Goldstein HS, Carlton PL. Uric acid level increases in humans engaged in gambling: A preliminary report. Biol Psychol. 1993; 36: 223–9.
• 9. Rosier M, Fischer R, Ammer R, Ose C, Retz W. A randomised, placebocontrolled, 24-week, study of low-dose extended-release methylphenidate in adults with attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. 2009; 259: 120–9.
• 10. Ortiz R, Ulrich H, Zarate Jr CA, Machado-Vieira R. Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics. Prog Neuropsychopharmacol Biol Psychiatry. 2015; 57: 117-31. doi: 10.1016/j.pnpbp.2014.10.016.
• 11. Bartoli F, Crocamo C, Mazza MG, Clerici M, Carra G. Uric acid levels in subjects with bipolar disorder: a comparative meta-analysis. J Psychiatr Res. 2016; 81: 133–9. doi: 10.1016/j.jpsychires.2016.07.007.
• 12. Black CN, Bot M, Scheffer PG, Snieder H, Penninx BW. Uric acid in major depressive and anxiety disorders. J Affect Disord. 2018; 225: 684–90. doi: 10.1016/j.jad.2017.09.003
• 13. Mabrouk H, Houas I, Mechria H, Mechri A, Douki W, Gaha L, et al. Oxidative stress markers in schizophrenic patients. Immuno-analyse & Biologie Spécialisée. 2013; 28 (1): 51–6.
• 14. American Psychiatric Association (2013b) The Personality Inventory DSM-5 (PID-5) Self-Report Form (full version). Arlington: American Psychiatric Publishing.
• 15. Elbir M, Alp Topbaş Ö, Bayad S, Kocabaş T, Topak Oz, Çetin Ş, et al. DSM-5 Kişilik Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-5-PD)'nin Türkçeye Uyarlanması ve Psikometrik Özellikleri. Türk Psikiyatri Dergisi. 2019; 30(1). doi:10.5080/u23431
• 16. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995; 51: 768-74.
• 17. H Güleç, L Tamam, MY Güleç, Karakuş G, Zengin M, Stanford MS. Barratt dürtüsellik ölçeği-11 (BIS-11)’nin Türkçe uyarlamasının psikometrik özellikleri. Klinik Psikofarmakoloji Bülteni. 2008; 18: 251-8.
• 18. Johnson RJ, Gold MS, Johnson DR, Ishimoto T, Lanaspa MA, Zahniser NR, et al. Attention-deficit/hyperactivity disorder: is it time to reappraise the role of sugar consumption? Postgrad Med. 2011; 123(5): 39-49. doi: 10.3810/pgm.2011.09.2458.
• 19. Kesebir S, Tatlidil YE, Suner O, Gultekin BK. Uric acid levels may be a biological marker for the differentiation of unipolar and bipolar disorder: the role of affective temperament. J Affect Disord. 2014; 165: 131–4.
• 20. Jahangard L, Soroush S, Haghighi M, Ghaleiha A, Bajoghli H, Holsboer-Trachsler E, et al. In a double-blind, randomized and placebo-controlled trial, adjuvant allopurinol improved symptoms of mania in in-patients suffering from bipolar disorder. Eur Neuropsychopharmacol. 2014; 24(8): 1210-21. doi: 10.1016/j.euroneuro.2014.05.013.
• 21. Machado-Vieira R, Lara DR, Souza DO, Kapczinski F. Therapeutic efficacy of allopurinol in mania associated with hyperuricemia. J Clin Psychopharmacol. 2001; 21(6): 621–2.
• 22. Burnstock G. Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov. 2008; 7(7): 575–90.
• 23. Schretlen DJ, Ward J, Meyer SM, Yun J, Puig JG, Nyhan WL, et al. Behavioral aspects of Lesch-Nyhan disease and its variants. Dev Med Child Neurol. 2005; 47: 673–7.
• 24. Kring AM, Johnson SL, Davison G, Neale J. Anormal Psikolojisi/Psikopatoloji. İstanbul: Nobel Akademik Yayıncılık, 2017.
• 25. Goodman MA, Wheelock MD, Harnett NG, Mrug S, Granger DA, Knigh DC. The hippocampal response to psychosocial stress varies with salivary uric acid level. Neuroscience. 2016; 17(339): 396-401. doi: 10.1016/j.neuroscience.2016.10.002.
• 26. Machado-Vieira R, Soares JC, Lara DR, Luckenbaugh DA, Busnello JV, Marca G, et al. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry. 2008; 69 (8): 1237–145.
• 27. Ring HA, Heller AJ, Marshall WJ, Johnson AL, Reynolds EH. Plasma uric acid levels in patients receiving anticonvulsant monotherapy. Epilepsy Res. 1991; 8(3): 241–4.
• 28. Sutin AR, Ferrucci F, Zonderman AB, Terracciano A. Personality and obesity across the adult lifespan. J Pers Soc Psychol. 2011; 101: 559–79.
• 29. Mouhamed DH, Ezzaher A, Neffati F, Douki W, Gaha L, Najjar MF. Effect of cigarette smoking on plasma uric acid concentrations. Environ Health Prev Med. 2011; 16: 307–12.