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The value of red cell distribution width for predicting subsequent preeclampsia

Year 2016, Volume: 41 Issue: 2, 224 - 228, 30.06.2016
https://doi.org/10.17826/cutf.199198

Abstract

Purpose: The purpose of our study was too assess the diagnostic value of red cell distribution width and other inflammatory markers such as white blood cell count and mean platelet volume during the first trimester of gestation for predicting the subsequent development of preeclampsia.
Material and Methods: A retrospective study was performed on 137 patients with preeclampsia and 150 normotensive pregnant women. Study group was assessed for presence of preeclampsia and the values of first trimester red cell distribution width, white blood cell count and mean platelet volume. The receiver operator curve was used to evaluate cut-off, sensitivity and specificity values.
Results: The optimal cut-off points to predict preeclampsia were a white blood cell count 10200 cells/mm3 or higher with a sensitivity of 75.1% and specificity of 44.1%, a mean platelet volume 8.6fL or lower with a sensitivity of 62.5% and specificity of 64.4% and a red cell distribution width 15.3% or lower with a sensitivity of 31.2% and specificity of 79.7%.
Conclusion: Regarding the association between first trimester red cell distribution width, white blood cell count and mean platelet volume, statistical analysis revealed that these markers were weak predictors of preeclampsia

References

  • Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357:53-6.
  • Altınbas S, Toğrul C, Orhan A, Yucel M, Danısman N. Increased MPV is not a significant predictor for preeclampsia during pregnancy. J Clin Lab Anal. 2012;26:403-6.
  • Zhang Z, Gao Y, Zhang L, Jia L, Wang P, Zhang L et al. Alterations of IL-6, IL-6R and gp130 in early and late onset severe preeclampsia. Hypertens Pregnancy. 2013;32:270-80.
  • Sacks GP, Seyani L, Lavery S, Trew G. Maternal Creactive protein levels are raised at 4 weeks of gestation. Hum Reprod. 2004;19:1025-30.
  • Faas MM, Schuiling GA, Baller JF, Visscher CA, Bakker WW. A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats. Am J Obstet Gynecol. 1994;171:158-64.
  • Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press. 2012;21:177-81.
  • ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002;77:67-75.
  • Hadlock FP, Harrist RB, Martinez-Poyer J. In utero analysis of fetal growth: a sonographic weight standard. Radiology. 1991;181:129-33.
  • Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y. The role of the immune system in preeclampsia. Mol Aspects Med. 2007;28:192-209.
  • Pijnenborg R, Bland JM, Robertson WB, Brosens I. Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta. 1983;4:397-413.
  • Kurt RK, Aras Z, Silfeler DB, Kunt C, Islimye M, Kosar O. Relationship of Red Cell Distribution Width With the Presence and Severity of Preeclampsia. Clin Appl Thromb Hemost. 2015;21:128-31.
  • Arhan M, Önal İK, Taş A, Kurt M, Kalkan İH, Özin Y et al. The role of red cell distribution width as a marker in inflammatory bowel disease. Turk J Med Sci. 2011;41:227-34.
  • Shehata HA, Ali MM, Evans-Jones JC, Upton GJ, Manyonda IT. Red cell distribution width (RDW) changes in pregnancy. Int J Gynaecol Obstet. 1998;62:43-6.
  • Inanc T, Kaya MG, Yarlioglues M, Ardic I, Ozdogru I, Dogan A et al. The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. Blood Press. 2010;19:81-5.
  • Kosus N, Kosus A, Turhan N. Mean platelet volume as a marker of future cardiovascular disease risk in pregnant women with impaired fasting glucose and impaired glucose tolerance. Turk J Med Sci. 2012;42:245-51.
  • Ekiz F, Yüksel O, Koçak E, Yılmaz B, Altınbaş A, Çoban S et al. Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B. J Clin Lab Anal. 2011;25:162–5.
  • Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N et al. An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume. Platelets. 2009;20:277–81.
  • Oylumlu M, Ozler A, Yildiz A, Oylumlu M, Acet H, Polat N et al. New inflammatory markers in preeclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio. Clin Exp Hypertens. 2014;36:503-7.
  • Felfernig-Boehm D, Salat A, Vogl SE, Murabito M, Felfernig M, Schmidt D et al. Early detection of preeclampsia by determination of platelet aggregability. Thromb Res 2000; 98:139-146.
  • Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW et al: First-trimester prediction of preeclampsia in nulliparous women at low risk. Obstet Gynecol. 2012;119:1234-42.

Eritrosit dağılım genişliğinin sonradan gelişen preeklampsiyi öngörmedeki değeri

Year 2016, Volume: 41 Issue: 2, 224 - 228, 30.06.2016
https://doi.org/10.17826/cutf.199198

Abstract

Amaç: Bu çalışmanın amacı ilk trimester eritrosit dağılım genişliği, lökosit sayısı ve ortalama platelet hacmi gibi inflamatuar markerların sonradan gelişen preeklampsiyi belirlemedeki tanısal değerini belirlemektir.
Gereç ve Yöntem: Preeklampsili 137 hasta ve 150 normal tansiyonlu hasta retrospektif olarak incelendi. Çalışma grubu preeklampsinin varlığına ve ilk trimester eritrosit dağılım genişliği, lökosit sayısı ve ortalama platelet hacmi açısından değerlendirildi. Eşik değeri, sensitivite ve spefisite değerlerini belirmek için ROC eğrisi kullanıldı.
Bulgular: Preeklampsiyi öngörmede lökosit için optimal eşik değeri ≥10200 hücre/mm3, sensitivite %75.1 ve spesifisite %44.1; ortalama platelet hacmi için optimal eşik değeri ≤ 8.6fL, sensitivite %62.5 ve spesifisite %64.4; eritrosit dağılım genişliği için optimal eşikd eğeri %15.3, sensitivite %31.2 ve spesifisite %79.7 olarak belirlendi. 
Sonuç: İlk trimester eritrosit dağılım genişliği, ortalama platelet hacmi ve lökosit değerleri preeklampsiyi öngörmede zayıf öngörücü belirteçlerdir.

References

  • Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357:53-6.
  • Altınbas S, Toğrul C, Orhan A, Yucel M, Danısman N. Increased MPV is not a significant predictor for preeclampsia during pregnancy. J Clin Lab Anal. 2012;26:403-6.
  • Zhang Z, Gao Y, Zhang L, Jia L, Wang P, Zhang L et al. Alterations of IL-6, IL-6R and gp130 in early and late onset severe preeclampsia. Hypertens Pregnancy. 2013;32:270-80.
  • Sacks GP, Seyani L, Lavery S, Trew G. Maternal Creactive protein levels are raised at 4 weeks of gestation. Hum Reprod. 2004;19:1025-30.
  • Faas MM, Schuiling GA, Baller JF, Visscher CA, Bakker WW. A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats. Am J Obstet Gynecol. 1994;171:158-64.
  • Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press. 2012;21:177-81.
  • ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002;77:67-75.
  • Hadlock FP, Harrist RB, Martinez-Poyer J. In utero analysis of fetal growth: a sonographic weight standard. Radiology. 1991;181:129-33.
  • Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y. The role of the immune system in preeclampsia. Mol Aspects Med. 2007;28:192-209.
  • Pijnenborg R, Bland JM, Robertson WB, Brosens I. Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta. 1983;4:397-413.
  • Kurt RK, Aras Z, Silfeler DB, Kunt C, Islimye M, Kosar O. Relationship of Red Cell Distribution Width With the Presence and Severity of Preeclampsia. Clin Appl Thromb Hemost. 2015;21:128-31.
  • Arhan M, Önal İK, Taş A, Kurt M, Kalkan İH, Özin Y et al. The role of red cell distribution width as a marker in inflammatory bowel disease. Turk J Med Sci. 2011;41:227-34.
  • Shehata HA, Ali MM, Evans-Jones JC, Upton GJ, Manyonda IT. Red cell distribution width (RDW) changes in pregnancy. Int J Gynaecol Obstet. 1998;62:43-6.
  • Inanc T, Kaya MG, Yarlioglues M, Ardic I, Ozdogru I, Dogan A et al. The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. Blood Press. 2010;19:81-5.
  • Kosus N, Kosus A, Turhan N. Mean platelet volume as a marker of future cardiovascular disease risk in pregnant women with impaired fasting glucose and impaired glucose tolerance. Turk J Med Sci. 2012;42:245-51.
  • Ekiz F, Yüksel O, Koçak E, Yılmaz B, Altınbaş A, Çoban S et al. Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B. J Clin Lab Anal. 2011;25:162–5.
  • Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N et al. An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume. Platelets. 2009;20:277–81.
  • Oylumlu M, Ozler A, Yildiz A, Oylumlu M, Acet H, Polat N et al. New inflammatory markers in preeclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio. Clin Exp Hypertens. 2014;36:503-7.
  • Felfernig-Boehm D, Salat A, Vogl SE, Murabito M, Felfernig M, Schmidt D et al. Early detection of preeclampsia by determination of platelet aggregability. Thromb Res 2000; 98:139-146.
  • Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW et al: First-trimester prediction of preeclampsia in nulliparous women at low risk. Obstet Gynecol. 2012;119:1234-42.
There are 20 citations in total.

Details

Primary Language English
Journal Section Research
Authors

Cenk Gezer

Atalay Ekin This is me

Ulaş Solmaz This is me

Mehmet Özeren This is me

Cüneyt Taner This is me

Gökhan Tosun This is me

Publication Date June 30, 2016
Published in Issue Year 2016 Volume: 41 Issue: 2

Cite

MLA Gezer, Cenk et al. “The Value of Red Cell Distribution Width for Predicting Subsequent Preeclampsia”. Cukurova Medical Journal, vol. 41, no. 2, 2016, pp. 224-8, doi:10.17826/cutf.199198.