Daptomisin alan hastalarda gelişen ani solunum yetmezliği ve eozinofilik pnömoni: beş olgunun sunumu

Year 2016, Volume: 41 Issue: 2, 396 - 399, 30.06.2016

Süheyla Kömür Aslıhan Ulu Behice Kurtaran Ayşe İnal Ferit Kuşçu Deniz Tekin Yeşim Taşova

https://doi.org/10.17826/cutf.208261

Cited By: 2

Abstract

Daptomisin, dirençli gram pozitif enfeksiyonların tedavisinde kullanıma giren siklik lipopeptidlerin ilk üyesidir. Gram pozitif bakteriler ile oluşan ciddi enfeksiyonların tedavisinde iyi bir seçenek olabileceği çeşitli çalışmalarda gösterilmiştir. Eozinofilik pnömoni daptomisin kullanımı sırasında nadiren gelişebilir. Bu yazıda daptomisin ilişkili eozinofilik pnömoni düşünülen 5 olgu sunulmuştur. Hastalarda ani gelişen solunum yetmezliği, takipne, taşikardi görülmüş, bir olguda periferik eozinofili saptanmıştır. Destek tedavisi ve ilacın kesilmesiyle genellikle semptomlar kontrol altına alınmış, ancak bazı hastalarda steroid ve mekanik ventilasyon ihtiyacı olmuştur. Daptomisin kullanımı esnasında ani gelişen solunum yetmezliğinde eozinofilik pnömoni akılda tutulmalıdır.

Keywords

Daptomisin, eozinpfilik pnömoni

Sudden respiratory failure and eosinophilic pneumonia in patients treated with daptomycin: a report of five cases

Abstract

Daptomycin is the first member of cyclic lipopeptides came into use in the treatment of resistant gram-positive infections. It is shown to be a good option in the treatment of serious infections caused by gram-positive bacteria. Eosinophilic pneumonia may occur rarely during the use of daptomycin. In this paper we described 5 cases of daptomycin-associated eosinophilic pneumonia. Sudden onset of respiratory failure with tachypnea, tachycardia was observed, peripheral eosinophilia was detected in one patient. The symptoms usually resolved with supportive treatment and after discontinuation of the drug, but steroid treatment and mechanical ventilation was required in some patients. Eosinophilic pneumonia in the sudden onset of respiratory failure should be kept in mind during daptomycin treatment.

Keywords

-

References

• Kosmidis C, Levine DP. Daptomycin: pharmacology and clinical use. Expert Opin Pharmacother. 2010;11:615-25.
• Philit F, Etienne-Mastroianni B, Parrot A, Guerin C, Robert D, Cordler JF. Idiopathic acute eosinophilic pneumonia: a study of 22 patients. Am J Respir Crit Care Med. 2002;166:1235-9.
• Lal Y, Assimacopoulos AP. Two cases of daptomycin-induced eosinophilic pneumonia and chronic pneumonitis. Clin Infect Dis. 2010;50:737- 40.
• Phillips J, Cardile AP, Patterson TF, Lewis II JS. Daptomycin-induced acute eosinophilic pneumoniae: Analysis of the current data and illustrative case reports. Scand J Infect Dis. 2013;45:804-8.
• Mikerov AN, Gan X, Umstead TM, Miller L, Chinchilli VM, Phelps DS et al. Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection. Respir Res. 2008;9:24.
• Miller BA, Gray A, LeBlanc TW, Sexton DJ. Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases. Clin Infect Dis. 2010;50:e63- e68.
• Hayes D Jr, Anstead MI, Kuhn RJ. Eosinophilic pneumonia induced by daptomycin. J Infect. 2007;54:e211-3