Abstract
İlaca bağlı kutanöz alerjik reaksiyonlar atropin, antikonvülzanlar ve benzodiyazepinler gibi birçok ilaç türü ile ortaya çıkabilir. Fakat bezodiyazepinlere bağlı alerjik reaksiyonlar oldukça nadirdir. Alprazolam antihistaminerjik etkisinden dolayı refraktör idiyopatik ürtiker tedavisinde faydalı olabilecek bir benzodiyazepindir. Alprazolamın antihistaminerjik etkisine rağmen literatürde alprazolam ile tetiklenen bir anjioödem vakası ve bir de soğuk ürtikeri vakası bilinmektedir. Bu olguda biz tek doz alprazolamdan dolayı kutanöz alerjik reaksiyon gelişen bir çocuğu sunacağız.
Keywords
References
- Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology. 2005;209:123-9.
- Bachot N, Roujeau JC. Differential diagnosis of severe cutaneous drug eruptions. Am J Clin Dermatol. 2003;4:561-72.
- Hernandez-Salazar A, Rosales SP, Rangel-Frausto S, Criollo E, Archer-Dubon C, Orozco-Topete R. Epidemiology of adverse cutaneous drug reactions. A prospective study in hospitalized patients. Arch Med Res. 2006;37:899-902.
- Pichler WJ. Delayed drug hypersensitivity reactions. Ann Int Med. 2003;139:683-93.
- Warnock JK, Morris DW. Adverse cutaneous reactions to antidepressants. Am J Clin Dermatol. 2002;3:329-39.
- Shin HT, Change MW. Drug eruptions in children. Curr Probl Dermatol. 2002;14:147-82.
- Bigby M. Rates of cutaneous reactions to drugs. Arch Dermatol. 2001;137:765-70.
- Impicciatore P, Choonara I, Clarkson A, Provasi D, Pandolfini C, Bonati M. Incidence of adverse drug reaction in pediatric in\out patients: a systemic review and metaanalysis of prospective studies. Br J Clin Pharmacol. 2001;52:77-83.
- Paller AS, Mancini AJ. Hurwitz Clinical Pediatric Dermatology. 3rd ed. Elsevier; 2006:525-39.
- Ghosh JS. Allergy to diazepam and other benzodiazepines. Br Med J. 1977;1:902-3.
- Sellas-Dupre G, Nieto-López M, García-Vicente JA, Salvador-Chiva J. Alprazolam-induced tongue angioedema. Med Clin (Barc). 2006;127:399.
- Gandolfo-Cano M, González-Mancebo E, Gonzálezde Olano D, Meléndez-Baltanás A, MohedanoVicente E. Cold urticarial induced by alprazolam. J Investig Allergol Clin Immunol. 2012;22:222.
- Kandemir H, Yumru M, Kul M, Kandemir SB. Behavioral disinhibition, suicidal ideation, and selfmutilation related to clonazepam. J Child Adolesc Psychopharmacol. 2008;18:409.
- Dueñas-Laita A, Ruiz-Muñoz P, Armentia A, Pinacho F, Martín-Armentia B. Successful treatment of chronic drug-resistant urticaria with alprazolam. J Allergy Clin Immunol. 2009;123:504-5.
Abstract
Cutaneous allergic reactions due to drug intake may be triggered by many types of drugs such as atropine, anticonvulsants and benzodiazepines. But allergic reactions due to benzodiazepines are extremely rare. Alprazolam is a benzodiazepine which may be useful for refractory idiopathic urticaria due to antihistaminergic effect. Although antihistaminergic effect of alprazolam, a cold urticaria case and an angioedema case induced by alprazolam are known in the literature. In the case, we present a child suffering from cutaneous allergic reaction due to alprazolam at the first dose taken.
Keywords
References
- Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology. 2005;209:123-9.
- Bachot N, Roujeau JC. Differential diagnosis of severe cutaneous drug eruptions. Am J Clin Dermatol. 2003;4:561-72.
- Hernandez-Salazar A, Rosales SP, Rangel-Frausto S, Criollo E, Archer-Dubon C, Orozco-Topete R. Epidemiology of adverse cutaneous drug reactions. A prospective study in hospitalized patients. Arch Med Res. 2006;37:899-902.
- Pichler WJ. Delayed drug hypersensitivity reactions. Ann Int Med. 2003;139:683-93.
- Warnock JK, Morris DW. Adverse cutaneous reactions to antidepressants. Am J Clin Dermatol. 2002;3:329-39.
- Shin HT, Change MW. Drug eruptions in children. Curr Probl Dermatol. 2002;14:147-82.
- Bigby M. Rates of cutaneous reactions to drugs. Arch Dermatol. 2001;137:765-70.
- Impicciatore P, Choonara I, Clarkson A, Provasi D, Pandolfini C, Bonati M. Incidence of adverse drug reaction in pediatric in\out patients: a systemic review and metaanalysis of prospective studies. Br J Clin Pharmacol. 2001;52:77-83.
- Paller AS, Mancini AJ. Hurwitz Clinical Pediatric Dermatology. 3rd ed. Elsevier; 2006:525-39.
- Ghosh JS. Allergy to diazepam and other benzodiazepines. Br Med J. 1977;1:902-3.
- Sellas-Dupre G, Nieto-López M, García-Vicente JA, Salvador-Chiva J. Alprazolam-induced tongue angioedema. Med Clin (Barc). 2006;127:399.
- Gandolfo-Cano M, González-Mancebo E, Gonzálezde Olano D, Meléndez-Baltanás A, MohedanoVicente E. Cold urticarial induced by alprazolam. J Investig Allergol Clin Immunol. 2012;22:222.
- Kandemir H, Yumru M, Kul M, Kandemir SB. Behavioral disinhibition, suicidal ideation, and selfmutilation related to clonazepam. J Child Adolesc Psychopharmacol. 2008;18:409.
- Dueñas-Laita A, Ruiz-Muñoz P, Armentia A, Pinacho F, Martín-Armentia B. Successful treatment of chronic drug-resistant urticaria with alprazolam. J Allergy Clin Immunol. 2009;123:504-5.
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | June 30, 2016 |
| Published in Issue | Year 2016 Volume: 41 Issue: 2 |
