Postmenapozal kadınlarda kas iskelet sistemi ağrılarının D vitamini eksikliği ile ilişkisi

Year 2017, Volume: 42 Issue: 3, 470 - 476, 30.09.2017

Eda Çelik Güzel

https://doi.org/10.17826/cutf.278137

Abstract

Amaç: Bu çalışmanın amacı postmenapozal dönemdeki kadınlarlarda görülen kas iskelet sistemi ağrılarının ortaya çıkmasında D vitamini eksikliğinin etkisini araştırmaktır

Gereç ve Yöntem: Çalışma postmenapozal dönemde olan 130 hasta ve 50 sağlıklı gönüllüden oluşturuldu. Hasta ve kontrol grubunda hastaların demografik bilgileri ve visual analog skala (VAS) ile ağrı skorları belirlendi. Serum 25 hidroksi D vitamini (25(OH)D), Östrodiol (E2), kalsiyum, fosfor, alkalen fosfataz (ALP) ve parathormon (PTH) düzeyleri değerlendirildi.

Bulgular: Çalışmaya katılan hastaların yaş ortalaması 51.03±4.22 ve kontrol grubunun ise 48.37± 5.47 yıldı. Serum 25 (OH) D düzeyi hasta grubunda kontrol grubuna göre anlamlı olarak düşüktü. Kalsiyum, fosfor, ALP ve PTH düzeyleri arasında her iki grup arasında farklılık görülmedi. Ağrı durumunu değerlendirmek için kullanılan VAS ağrı skoru hasta grubunda kontrol grubuna göre anlamlı olarak yüksek saptandı. Postmenapozal hastalarda VAS ağrı skorları D vitamini eksikliği ve yetersizliği olan gruplarda, D vitamini düzeyleri yeterli olan gruba göre anlamlı olarak yüksek saptandı. Hasta grubunda uygulanan korelasyon analizinde 25 (OH) D düzeyleri ile yaş, vücut kütle indeksi ve VAS skoru arasında negatif korelasyon ve egzersiz ve E2 arasında pozitif korelasyon saptandı. 

Sonuç: Postmenapozal hastalarda ağrı şiddetindeki artışın serum 25 (OH) D düzeylerindeki azalmayla ilişkili olduğunu göstermektedir. Üstelik 25(OH)D düzeyleri düşük hastalarda alt ekstremite ağrılarının daha fazla görüldüğü veserum  25 (OH) D’nin  kas iskelet sistemi ağrılarının şiddetini belirlemede rol oynayabileceği kanısındayız.

Keywords

Postmenapozal dönem, D vitamini

Relationship between vitamin D deficiency and musculoskeletal pain in postmenopausal women

Abstract

Purpose: The aim of this study was to investigate the effect of vitamin D deficiency on the appearance of musculoskeletal pain seen in postmenopausal women.

Material and Methods: The study consisted of 130 patients in the postmenopausal period and 50 healthy volunteers. Patients and control group were assessed with demographic information and visual analogue scale (VAS) and pain scores. Serum 25-hydroxyvitamin D (25 (OH) D), estradiol (E2) calcium, phosphorus, alkaline phosphatase (ALP) and parathormone (PTH) levels were evaluated.

Results: The mean age of the subjects participating in the study was 51.03±4.22 and the control group was 48.27±5.47 years. Serum 25 (OH) D level was significantly lower in the patient group than in the control group. There was no difference between the two groups in calcium, phosphorus, ALP and PTH levels. The VAS pain score used to assess pain status was significantly higher in the patient group than in the control group (p<0.001). VAS pain scores in Postmenopausal patients were significantly higher in patients with vitamin D deficiency and inadequate than those with adequate vitamin D levels. In patients group serum 25(OH) D were negatively correlated with age, body mass index and VAS score and positively correlated with exercise and E2.

Conclusion: The increase in pain intensity in postmenopausal patients is associated with a decrease in serum 25 (OH) D levels. Moreover, we believe that 25 (OH) D levels are more common in patients with lower levels of the lower extremities and that serum 25 (OH) D may play a role in determining the severity of musculoskeletal pain.

Keywords

Postmenopausal period, vitamin D

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