Relationship between obesity and platelet indices in children

Year 2018, Volume: 43 Issue: 1, 30 - 35, 31.03.2018

Elif Özsu , Bahadır Yazıcıoglu

https://doi.org/10.17826/cumj.340109

Cited By: 3

Abstract

Purpose: The aim of this study was to assess platelet count, MPV and PDW as metabolic indicator in obese children with or without insuline resistances.

Materials and Methods: Two hundered sixtyseven obese patients (160 female) and 50 (25 female) controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid, hemoglobin, platelet count, MPV, PDW  and insulin resistance by using  homeostasis model of assessment of insulin resistance (HOMA-IR)  and  oral glucose tolerance test were investigated. 

Results: Uric acid level were significantly higher in the obese group while there was no statistically significantly differences in platelet indices between in the  two groups. Platelet counts, MPV and PDW levels were not significantly different between in three groups. However MPV inversely correlated with HOMA-IR, platelet counts, ALT and LDL levels and positively correlated with PDW. 

Conclusion: The relationship between platelets, MPV, PDW has previously been demonstrated. However   platelet indices may not to be related to  degree of obesity as currently thought.  Uric acid may be a more useful marker for selected patients with insulin resistance.

Keywords

Childhood, Obesity, Platelet, Mean platalet volume

Çocuklarda trombosit indeksleri ve obesite arasındaki ilişki

Abstract

Amaç: Bu çalışmada insulin direnci olan ve olmayan obez çocuklarda trombosit sayısı, ortalama trombosit volümü (MPV) ve trombosit dağılım genişliği (PDW)  parametrelerinin metabolik bir belirleyici olarak kullanılıp kullanılamayacağını göstermeyi amaçladık. 

Gereç ve Yöntem: Çalışmaya 267 obez  çocuk  ( kız 160) ve 50 ( 25 kız) kontrol alındı. Antropometrik ölçümler, serum trigliserid,total kollesterol, yüksek dansiteli lipoprotein kollesterol  (HDL), düşük dansiteli lipoprotein kolesterol (LDL), Alanin aminotransferaz( ALT)  Asparta aminotransferaz (AST), ürik asit, hemogloulin, , trombosit sayısı, MPV, PDW tüm hastalarda bakıldı.  İnsulin direnci homostatik model assesmant (HOMA-IR) kullanarak ve oral glikoz yükleme testi (OGTT) yapılarak belirlendi. 

Bulgular: Ürik asit değerleri obez grupta anlamlı yüksek saptandı. Ancak trombosit indeksleri arasında istatistiksel anlamlı fark bulunamadı. Trombosit sayısı, MPV,PDW değerleri insulin direnci olan, olmayan ve control grubunda istatistiksel olarak anlamlı farklı saptanmadı. Buna ragmen MPV HOMA-IR değeri, trombosit sayısı ,ALT ve LDL  arasında arasında  negatif yönde korelasyon varken MPV ile PDW arasında pozitif korelasyon saptandı.

Sonuç: Obezite ile trombosit sayısı, PDW ve MPV arasındaki ilişki daha önce gösterilmiştir. Biz düşündüğümüz gibi trombosit indeksleri ile obezite derecesi arasında bir ilişki saptayamadık. Ancak insulin direncini belirlemede seçilmiş hastalarda ürik asit düzey ölçümü daha yararlı olabilir. 

Keywords

Çocukluk, obezite, trombosit, ortalama platalet birim

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