Seroprevalence of Hepatitis B, Hepatitis C and HIV in Patients with Hemoglobinopathy Patients

Year 2014, Volume: 39 Issue: 4, 0 - , 22.07.2014

Gül İlhan Fuat Ekiz Can Acıpayam Gonul Oktay

https://doi.org/10.17826/cutf.49433

Abstract

Purpose: Thalassemia and sickle cell anemia patients have frequent transfusions. Hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) are tramsmitted infections with blood. The objective of this study is to determine frequency of these infections in our hemoglobinopathy patients. Material and Methods: We investigated 410 hemoglobinopathy patients. Viral serologies were detected with second-generation enzyme-linked immunosorbent assay method. In 410 patients (116 thalassemia major, 16 thalassemia intermedia, 12 hemoglobin H, 222 sickle cell anemia, 43 sickle-beta thalassemia and 1 Hb SE), there were 258 males and 152 females. Results: The rate of HBV is 1,2%, HCV is 3,2% and HIV is 0%. Our results shows that transfusion transmitted viral infection prevelance is not high compared to the literature. Conclusion: Using sensitive screening tests with periodically and right donor selection are very important for preventing these infections in hemoglobinopathy patients who are under high risk.

Keywords

viral hepatitis, HIV, hemoglobinopathy

Hemoglobinopati Hastalarında Hepatit B, Hepatit C ve HIV Seroprevalansı

Abstract

Amaç: Talasemi ve orak hücreli anemi hastaları sık transfüzyon almaktadır. Hepatit B (HBV), hepatit C (HCV) ve insan immün yetmezlik virüsü (HIV) kanla geçmektedir. Bu çalışmanın amacı hemoglobinopati hastalarımızda bu enfeksiyonların sıklığını belirlemektir. Materyal ve Metod: Dört yüz on hemoglobinopati hastasını inceledik.Viral serolojiler "ikinci jenerasyon enzim bağlantılı immün absorban tahlil" metoduyla incelendi. Dört yüz on hastanın (116 talasemi major, 16 talasemi intermedia, 12 hemoglobin H, 222 orak hücreli anemi, 43 orak-beta talasemi ve 1 Hb E) 258"i erkek, 152"si kadındı. Bulgular: HBV sıklığı %1,2, HCV %3,2 ve HIV %0 bulundu. Sonuçlarımız göstermektedir ki transfüzyon ilişkili viral enfeksiyon sıklığı literatüre kıyasla daha yüksek değildir. Sonuç: Peryodik olarak duyarlı tarama testlerinin kullanılması ve doğru verici seçimi yüksek risk altındaki hemoglobinopati hastalarının bu enfeksiyolarda korunmasında çok önemlidir.

Keywords

viral hepatit, HIV, hemoglobinopati

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• Kabul tarihi/Accepted on: 28.05.2014