Life-threatening Anemia with Hemolysis, Thrombocytopenia and Brain Atrophy due to Vitamin B12 Deficiency

Year 2014, Volume: 39 Issue: 4, 0 - , 22.07.2014

Ebru Yılmaz Keskin Hilal Kabasakal Hülya İnce Mahmut Keskin Mahir İğde Banu Gülcan Öksüz

https://doi.org/10.17826/cutf.46278

Abstract

Megaloblastic anemia due to vitamin B12 deficiency is rare in infancy. It usually occurs in exclusively breast-fed infants born to vitamin B12-deficient mothers. We report a one-year-old female infant with initial diagnosis of leukemia who was found severely vitamin B12-deficient secondary to maternal deficiency. She had marked neurodevelopmental retardation, and presented with life-threatening anemia, findings of hemolysis, thrombocytopenia and cerebral atrophy on magnetic resonance imaging.

Keywords

Vitamin B12 deficiency hemolysis, thrombocytopenia, growth failure, neuromotor retardation

B12 Vitamini Eksikliğine İkincil Hemoliz Bulguları Olan Yaşamı Tehdit Eden Anemi, Trombositopeni ve Beyin Atrofisi

Abstract

Süt çocukluğu döneminde B12 vitamini eksikliğine bağlı megaloblastik anemi nadirdir. Bu durum genellikle, annesinde B12 depoları yetersiz olan ve sadece anne sütü ile beslenen bebeklerde görülür. Kendisinde başlangıçta lösemi tanısı düşünülen, ancak tetkikler sonrasında, annedeki eksikliğe ikincil ağır B12 eksikliği olduğu bulunan 1 yaşındaki bir kız hastayı sunmak istedik. Olguda belirgin nörogelişimsel gerilik, yaşamı tehdit eden anemi, hemoliz bulguları, trombositopeni ve kranial manyetik rezonans görüntülemede serebral atrofi mevcuttu.

Keywords

B12 vitamini eksikliği, hemoliz, trombositopeni, büyüme geriliği, nöromotor gerilik

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• YazışmaAdresi / Address for Correspondence: Dr. Ebru Yılmaz Keskin Samsun Education and Research Hospital Department of Pediatric Hematologyand Oncology 55100 İlkadım, SAMSUN
• E-mail: [e-mail] G eliştarihi/Received on : 05.03.2014
• Kabul tarihi/Accepted on: 14.04.2014