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Life-threatening Anemia with Hemolysis, Thrombocytopenia and Brain Atrophy due to Vitamin B12 Deficiency

Year 2014, Volume: 39 Issue: 4, 0 - , 22.07.2014
https://doi.org/10.17826/cutf.46278

Abstract

Megaloblastic anemia due to vitamin B12 deficiency is rare in infancy. It usually occurs in exclusively breast-fed infants born to vitamin B12-deficient mothers. We report a one-year-old female infant with initial diagnosis of leukemia who was found severely vitamin B12-deficient secondary to maternal deficiency. She had marked neurodevelopmental retardation, and presented with life-threatening anemia, findings of hemolysis, thrombocytopenia and cerebral atrophy on magnetic resonance imaging.

References

  • Honzik T, Adamovicova M, Smolka V et al.. Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency--what have we learned? Eur J PaediatrNeurol 2010;14:488-95.
  • Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med 2013;368:149-60.
  • Demir N, Koc A, Ustyol L, et al.. Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. J Paediatr Child Health 2013;49:820-4.
  • Sekhar J, Stabler SP. Life-threatening megaloblastic pancytopenia with normal mean cell volume: Case series. Eur J Intern Med 2007;18:548-50.
  • Yenicesu I. Pancytopenia due to vitamin B12 deficiency in a breast-fed infant. PediatrHematolOncol 2008;25:365-7.
  • Citak FE, Citak EC. Severe vitamin B12 deficiency in a breast fed infant with pancytopenia. J Trop Pediatr 2011;57:69-70.
  • Acharya U, Gau JT, Horvath W et al..Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature. J HematolOncol 2008;1:26.
  • Chandra J, Jain V, Narayan S et al.. Tremors and thrombocytosis during treatment of megaloblastic anaemia. Ann Trop Paediatr 2006;26:101-5.
  • Demir N, Dogan M, Koc A et al.. Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms. CutanOculToxicol 20Doi:10.3109/15569527.2013.861477.
  • Quentin C, Huybrechts S, Rozen L et al.. Vitamin B12 deficiency in a 9-month-old boy. Eur J Pediatr 2012;171:193-5.
  • YazışmaAdresi / Address for Correspondence: Dr. Ebru Yılmaz Keskin Samsun Education and Research Hospital Department of Pediatric Hematologyand Oncology 55100 İlkadım, SAMSUN
  • E-mail: ebruyilmaz81@hotmail.com G eliştarihi/Received on : 05.03.2014
  • Kabul tarihi/Accepted on: 14.04.2014

B12 Vitamini Eksikliğine İkincil Hemoliz Bulguları Olan Yaşamı Tehdit Eden Anemi, Trombositopeni ve Beyin Atrofisi

Year 2014, Volume: 39 Issue: 4, 0 - , 22.07.2014
https://doi.org/10.17826/cutf.46278

Abstract

Süt çocukluğu döneminde B12 vitamini eksikliğine bağlı megaloblastik anemi nadirdir. Bu durum genellikle, annesinde B12 depoları yetersiz olan ve sadece anne sütü ile beslenen bebeklerde görülür. Kendisinde başlangıçta lösemi tanısı düşünülen, ancak tetkikler sonrasında, annedeki eksikliğe ikincil ağır B12 eksikliği olduğu bulunan 1 yaşındaki bir kız hastayı sunmak istedik. Olguda belirgin nörogelişimsel gerilik, yaşamı tehdit eden anemi, hemoliz bulguları, trombositopeni ve kranial manyetik rezonans görüntülemede serebral atrofi mevcuttu.

References

  • Honzik T, Adamovicova M, Smolka V et al.. Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency--what have we learned? Eur J PaediatrNeurol 2010;14:488-95.
  • Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med 2013;368:149-60.
  • Demir N, Koc A, Ustyol L, et al.. Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. J Paediatr Child Health 2013;49:820-4.
  • Sekhar J, Stabler SP. Life-threatening megaloblastic pancytopenia with normal mean cell volume: Case series. Eur J Intern Med 2007;18:548-50.
  • Yenicesu I. Pancytopenia due to vitamin B12 deficiency in a breast-fed infant. PediatrHematolOncol 2008;25:365-7.
  • Citak FE, Citak EC. Severe vitamin B12 deficiency in a breast fed infant with pancytopenia. J Trop Pediatr 2011;57:69-70.
  • Acharya U, Gau JT, Horvath W et al..Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature. J HematolOncol 2008;1:26.
  • Chandra J, Jain V, Narayan S et al.. Tremors and thrombocytosis during treatment of megaloblastic anaemia. Ann Trop Paediatr 2006;26:101-5.
  • Demir N, Dogan M, Koc A et al.. Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms. CutanOculToxicol 20Doi:10.3109/15569527.2013.861477.
  • Quentin C, Huybrechts S, Rozen L et al.. Vitamin B12 deficiency in a 9-month-old boy. Eur J Pediatr 2012;171:193-5.
  • YazışmaAdresi / Address for Correspondence: Dr. Ebru Yılmaz Keskin Samsun Education and Research Hospital Department of Pediatric Hematologyand Oncology 55100 İlkadım, SAMSUN
  • E-mail: ebruyilmaz81@hotmail.com G eliştarihi/Received on : 05.03.2014
  • Kabul tarihi/Accepted on: 14.04.2014
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Research
Authors

Ebru Yılmaz Keskin This is me

Hilal Kabasakal This is me

Hülya İnce This is me

Mahmut Keskin This is me

Mahir İğde This is me

Banu Gülcan Öksüz This is me

Publication Date July 22, 2014
Published in Issue Year 2014 Volume: 39 Issue: 4

Cite

MLA Keskin, Ebru Yılmaz et al. “B12 Vitamini Eksikliğine İkincil Hemoliz Bulguları Olan Yaşamı Tehdit Eden Anemi, Trombositopeni Ve Beyin Atrofisi”. Cukurova Medical Journal, vol. 39, no. 4, 2014, doi:10.17826/cutf.46278.