Primary spinal cord glioblastoma multiforme presenting with transverse myelitis

Year 2014, Volume: 39 Issue: 3, 606 - 610, 22.07.2014

Melikhan Çerçi Begül Yağcı-küpeli Ali İhsan Ökten Kerem Mazhar Özsoy Tamer Çelik Fulya Adamhasan Ümit Çelik Suzan Zorludemir Serhan Küpeli

https://doi.org/10.17826/cutf.91183

Abstract

Primary spinal cord tumors are rarely encountered in childhood period. Ependymomas and pilocytic astrocytomas comprise the majority of spinal cord tumors in children. Spinal glioblastoma multiforme (GM) (grade IV astrocytoma) is a rare clinical entity accounting for only 1-3% of all pediatric intramedullary tumors. We report a 3- year-8- month-old male with primary spinal cord GM who presented with back pain, paraparesis, gait disturbance and loss of sphincter control and initially diagnosed as transverse myelitis.

Keywords

Spinal cord tumors, glioblastoma multiforme, transverse myelitis, childhood

Transvers miyelitle gelen bir primer spinal kord glioblastoma multiforme vakası

Abstract

Primer spinal kord tümörlerine çocukluk çağında nadiren rastlanır. Ependimomlar ve pilositik astrositomlar bunların başında gelir. Spinal glioblastoma multiforme pediatrik intramedüller tümörlerin %1-3'ünü oluşturan nadir bir antitedir.Bu yazıda sırt ağrısı, paraparezi, yürüme bozukluğu ve sfinkter fonksiyon kaybı ile başvuran ve başlangıçta transvers miyelit olarak değerlendirilen 3 yaş 8 aylık erkek hasta sunulmuştur. Klinisyenlere bu şekilde transvers miyelit bulgularıyla başvuran vakalarda intramedüller tümörlerin de ayırıcı tanıda akılda tutulması gerektiği önerilmiştir.

Keywords

Spinal kord tümörleri, glioblastoma multiforme, transverse myelitis, çocukluk çağı

References

• Stiller CA, Nectoux J. International incidence of childhood brain and spinal tumours. Int J Epidemiol. 1994;23:458-64.
• Yamamoto Y, Raffel C. Intraspinal extramedullary neoplasms. In:Albright A, Pollack I, Adelson P (eds) Operative techniques in Pediatric Neurosurgery. New York: Thieme. 2001;183-92.
• Lowis SP, Pizer BL, Coakham H et al. Chemotherapy for spinal cord astrocytoma: can natural history be modified? Childs Nerv Syst. 1998;14:317-21.
• Lee M, Rezai AR, Freed D, Epstein FJ. Intramedullary spinal cord tumors in neurofibromatosis. Neurosurgery. 1996;38:32-7.
• Andrews AA, Enriques L, Renaudin J, Tomivasu U. Spinal intramedullary glioblastoma with intracranial seeding. Report of a case. Arch Neurol. 1978;35:244
• Steinbok P, Cochrane DD, Poskitt K. Intramedullary spinal cord tumors in children. In:Berger MS (ed.) Pediatric Neurooncology. Philadelphia: Saunders, 1992, pp. 931-945.
• O’Halloran PJ, Farrell M, Caird J, Capra M, O’Brien D. Paediatric spinal glioblastoma: case report and review of therapeutic strategies. Childs Nerv Syst. 2013;29:367–74.
• Ferner RE. Neurofibromatosis I and neurofibromatosis 2: a twenty first century perspective. The Lancet Neurology. 2007;6:340-51.
• Morais N, Mascarenhas L, Soares-Fernandes J.P, Silva A, Magalhaes Z, Moreira Da Costa JA. Primary spinal glioblastoma: A case report and review of the literatüre Oncology Letters. 2013;5:992-6.
• Ciappetta P, Salvati M, Capoccia G et al. Spinal glioblastomas:report of seven cases and review of the literatüre. Neurosurgery. 1991;28:302-6.
• Nadkarni TD, Rekate HL. Pediatric intramedullary spinal cord tumors. Critical review of the literature. Childs Nerv Syst. 1999;15:17–28.
• Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987–96.
• Ononiwu C, Mehta V, Bettegowda C, Jallo GI. Pediatric spinal glioblastoma multiforme: current treatment strategies and possible predictors of survival. Childs Nerv Syst. 2012;28:715–20.
• Allen JC, Aviner S, Yates AJ, Boyett JM, Cherlow JM, Turski PA, Epstein F, Finlay JL. Treatment of high-grade spinal cord astrocytoma of childhood with “8-in-1” chemotherapy and radiotherapy: a pilot study of CCG-945. Children's Cancer Group. J Neurosurg. 1998;88:215–20.
• Finlay JL, Boyett JM, Yates AJ et al. Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight- drugs-in-1-day regimen. Childrens Cancer Group. J Clin Oncol. 1995;13:112–23.
• Cohen KJ, Pollack IF, Zhou T, Buxton A, Holmes EJ, Burger PC, Brat DJ, Rosenblum MK, Hamilton RL, Lavey RS, Heideman RL. Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group. Neuro Oncol. 2011;13:317–23.
• Santi M, Mena H, Wong K et al. Spinal cord malignant astrocytomas. Clinicopathologic features in 36 cases. Cancer. 2003;98:554-61.
• Ononiwu C, Mehta V, Bettegowda C, Jallo G. Pediatric spinal glioblastoma multiforme: current treatment strategies and possible predictors of survival Childs Nerv Syst. 2012;28:715–20.
• Yazışma Adresi / Address for Correspondence: Dr. Serhan Küpeli, Çukurova University, Faculty of Medicine, Department of Pediatric Oncology, ADANA GSM: 905327616752
• Email: [e-mail] G eliş tarihi/Received on: 31.09.2013
• Kabul tarihi/Accepted on:07.11.2013