Churg-Strauss Syndrome associated with montelukast: Three Case Reports

Year 2014, Volume: 39 Issue: 2, 347 - 352, 22.07.2014

Fatih Yıldız Suzan Zorludemir Eren Erken

https://doi.org/10.17826/cutf.72026

Abstract

Churg-Strauss syndrome (new name Eosinophilic granulomatosis and polyangiitis); asthma, fever, peripheral blood eosinophilia, eosinophilic tissue infiltration, small and medium sized arteries characterized by necrotizing granulomatous inflammation is a multisystemic disorder. Classified in ANCA associated vasculitis. The drugs such as leukotriene receptor antagonists (montelukast, zafirlukast, pranlukast), inhaled glucocorticoids, omalizumab, cocaine and clarithromycin is thought to be associated with Churg-Strauss Syndrome cases have been reported. Herein we presented a rare three CSS cases associated with montelukast.

Keywords

Churg Strauss Syndrome, leukotriene receptor antagonists, montelukast, vasculitis.

Montelukast ilişkili Churg Strauss Sendromu: Üç Olgu

Abstract

Churg-Strauss Sendromu yeni adıyla Eozinofilik Granülomatosis ve Polianjiitis; astım, ateş, periferik kanda eozinofili, eozinofilik doku infiltrasyonu, küçük ve orta çaptaki damarların nekrotizan granülomatöz inflamasyonu ile karakterize multisistemik bir hastalıktır. ANCA ilişkili vaskülitler içinde sınıflandırılmaktadır. Lökotrien reseptör antagonistleri (montelukast, zafirlukast, pranlukast), inhaler glukokortikoidler, omalizumab, kokain ve klaritromisin gibi ilaçlarla ilişkili olduğu düşünülen Churg-Strauss Sendromu vakaları bildirilmiştir. Burada montelukast ile ilişkili nadir görülen 3 CSS olgusu sunulmuştur.

Keywords

Churg Strauss Sendromu, Lökotrien reseptör antagonistleri, Montelukast, Vaskülit.

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• Yazışma Adresi / Address for Correspondence: Dr. Fatih Yıldız Çukurova Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı Romatoloji– İmmünoloji Bilim Dalı 01330, Balcalı Hastanesi Sarıçam/Adana Tlf: 0 322 338 6060/3146
• Email: [e-mail] geliş tarihi/received :22.08.2013 kabul tarihi/accepted:16.09.2013