Mediastinal Extranodal Follicular Dendritic Cell Sarcoma: A Case Report

Year 2014, Volume: 39 Issue: 2, 377 - 382, 22.07.2014

Arbil Açıkalın Emine Kılıç Bağır Eif Çalış Ezgi Özyılmaz Melek Ergin Derya Gümürdülü

https://doi.org/10.17826/cutf.82454

Abstract

Follicular dendritic cell sarcoma is a spindle cell neoplasm, originating from follicular dendritic cells. It frequently presents in lymph nodes. Occasionally, it occurs in extranodal regions like head and neck, mediastinum, gastrointestinal system. We present a 50 years old woman with mediastinal and metastatic follicular dendritic cell sarcoma with clinical and pathological findings. Follicular dendritic cell sarcoma is usually under-recognized because of the misleading histomorphology and the rarity of this tumor. Hence, this tumor has specific immunohistochemical markers, it is important to keep in mind this tumor in differential diagnosis of spindle cell tumors.

Keywords

extranodal, follicular dendritic cell sarcoma, immunohistochemistry, mediastinum

Mediasten Yerleşimli Ekstranodal Folliküler Dendritik Hücreli Sarkom; Olgu sunumu

Abstract

Folliküler dendritik hücreli sarkom, folliküler dendritik hücre kökenli, iğsi hücreli neoplazidir. Genellikle lenf nodlarında ortaya çıkar, baş-boyun, mediasten ve gastrointestinal sistem gibi ekstranodal bölgelerde de nadiren görülmektedir. Bu makalede, 50 yaşında, kadın hastada mediasten yerleşimli folliküler dendritik hücreli sarkom olgusunun klinik ve patolojik bulguları literatür eşliğinde tartışıldı. Hastanın yaşı ve tümörün mediasten yerleşimli olması nedeni ile ayırıcı tanıda lenfoma, timik neoplaziler, metastaz düşünüldü. Ancak immünohistokimyasal yöntemle vimentin ve CD21 pozitif saptandı ve olgu mediastinal yerleşimli folliküler dendritik hücreli sarkom olarak rapor edildi. Folliküler dendritik hücreli sarkom, yanıltıcı histomorfolojisi ve nadir görülmesi nedeniyle özgün immünohistokimyasal belirleyiciler ile kesin tanıya ulaşmak için ayırıcı tanıda akılda tutulmalıdır.

Keywords

ekstranodal, folliküler dendritik hücreli sarkom, immünohistokimya, mediasten.

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• Yazışma Adresi / Address for Correspondence: Dr. Arbil Açıkalın Çukurova Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı 01330, Balcalı Hastanesi Sarıçam/Adana
• Email: [e-mail] geliş tarihi/received :23.09.2013 kabul tarihi/accepted:24.10.2013