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Corpus Callosum Agenesis Presented With Attention Deficit Hyperactivity Disorder: Two Case Reports

Year 2013, Volume: 38 Issue: 4, 759 - 764, 01.12.2013

Abstract

ADHD is a treatable neuropsychiatric disorder which can continue till adulthood. There have been three subtypes including attention deficiency, hyperactivity and impulsivity. Its etiology remains unclear yet. It is hypothesized that there is an impairment of neurodevelopment in early developmental periods through the interactions between genetic and environmental processes. Corpus callosum provides an integration of cognitive, sensorial and motor functions of brain as a response to the impulses originating from the cortex. The damage of this region may result in deterioration of some cerebral functions such as cognitive functions, speaking, learning ability and impulse control. In this paper, we report two pediatric cases who had comorbid attention deficiency and corpus callosum agenesis without mental retardation.

References

  • Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and meta regression analysis. Am J Psychiatry. 2007;164:942-8
  • Schweitzer JB, Faber LT, Grafton ST, Tune LE, Hoffman JM, Kilts CD. Alterations in the functional anatomy of working memory in adult attention deficit hyperactivity disorder. Am J Psychiatry. 2000;157:278-80.
  • Jensen PS, Hinshaw SP, Swansom JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn JH, Severe JB, Vitiello B, Wells K, Wigal T. Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): Implications and applications for primary care providers. J Dev Behav Pediatr. 2001;22: 60-73.
  • Sonuga-Barke EJ, Halperin JM. Developmental phenotypes and causal pathways in attention deficit/hyperactivity disorder: potential targets for early intervention? J Child Psychol Psychiatry. 2010;51:368-89.
  • Taylor M, David AS. Agenesis of the corpus callosum: A United Kingdom series of 56 cases. J Neurol Neurosurg Psychiatry. 1998; 64:131-4.
  • Pisani F, Bianchi ME, Scarano A, Viola P, Volante E, Faienza C. Clinical features in subjects with congenital anomalies of the corpus callosum. Acta Biomed Ateneo Parmense. 2000; 71:497-502.
  • Glass HC, Shaw GM, Ma C, Sherr EH. Agenesis of the corpus callosum in California 1983-2003: a population-based study. Am J Med Genet. A. 2008;146:2495-2500.
  • Jeret JS, Serur D, Wisniewski K, Fisch C. Frequency of agenesis of the corpus callosum in the developmentally disabled population as determined by computerized tomography. Pediatr Neurosci. 1985;12:101-3.
  • Frazier JA, Breeze JL, Papadimitriou G, Kennedy DN, Hodge SM, Moore CM, Howard JD, Rohan MP, Caviness VS, Makris N: White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord. 2007;9:799–809.
  • Rueckert L, Levy J. Further evidence that the callosum is involved in sustaining attention. Neuropsychologia. 1996;34:927–35.
  • Barkovich AJ (ed). Pediatric Neuroimaging. Philadelphia: Lippincott Williams&Wilkins, 2000.
  • Giedd JN, Castellanos FX, Casey BJ, Kozuch P, King AC, Hamburger SD, Rapaport JL. Quantitative morphology of the corpus callosum in attention deficit hyperactivity disorder. Am J Psychiatry. 1994; 151:665-69.
  • Prasad AN, Bunzeluk K, Prasad C, Chodirker BN, Magnus KG, Greenberg CR. Agenesis of the corpus callosum and cerebral anomalies in inborn errors of metabolism. Journal of Japanese Teratology Society. 2007; 47:125–35.
  • Hynd GW, Semrud-Clikeman M, Lorys AR, Novey ES, Eliopulos D, Lyytinen H. Corpus callosum morphology in attention deficit-hyperactivity disorder: morphometric analysis of MRI. J Learn Disabil. 1991; 24; 141–6.
  • Lyoo IK, Noam GG, Lee CK, Lee HK, Kennedy BP, Renshaw PF. The corpus callosum and lateral ventricles in children with attention-deficit hyperactivity disorder: a brain magnetic resonance imaging study. Biol Psychiatry. 1996;40; 1060–63.
  • Hutchinson AD, Mathias JL, Banich MT. Corpus callosum morphology in children and adolescents with attention deficit hyperactivity disorder: a metaanalytic review. Neuropsychology. 2008; 22: 341–9.
  • Raybaud C, Girard N. The developmental disorders of the commissural plate of the telencephalon: MR imaging study and morphologic classification. Nerv Syst Child. 1999; 24: 348–57.
  • Symington SH, Paul LK, Symington MF, Ono M, Brown WS Social cognition in individuals with agenesis of the corpus callosum. Soc Neurosci. 2010;5:296-308
  • Yazışma Adresi / Address for Correspondence: Dr. Gonca Çelik Çukurova Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı 01330 Balca lı-ADANA e-mail: goncagulcelik@gmail.com geliş tarihi/received :15.02.2013 kabul tarihi/accepted:29.03.2013

Dikkat Eksikliği Hiperaktivite Bozukluğu İle Prezente Olan Corpus Callosum Agenezisi: İki Olgu Bildirimi

Year 2013, Volume: 38 Issue: 4, 759 - 764, 01.12.2013

Abstract

ÖZET: Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) erişkin hayatta da devam edebilen, tedavi edilebilir nöropsikiyatrik bir bozukluktur. Dikkat eksikliği, aşırı hareketlilik ve dürtüsellikle karakterize üç alt tipi bulunmaktadır. DEHB, etiyolojisi halen yeterince aydınlatılamamış bir alandır. DEHB de erken gelişim evrelerinde, çeşitli genetik ve çevresel etkenlerin etkileşimiyle, nörogelişimde bir aksama olduğu öne sürülmektedir. Korpus kallozum, korteksten köken alan uyaranları karşı taraf hemisfere bağlayarak beynin motor, duyusal ve kognitif performansını sağlamaktadır. Bu bölgede meydana gelen bir hasar kognitif beceriler, konuşma, ögrenme ve dürtü kontrol gibi beyin fonksiyonlarında bozulmaya neden olabilir. Bu yazıda; ilk ruhsal belirtileri dikkat eksikliği ve hiperaktivite olan iki çocuk olgudaki, korpus kallozum agenezisi ve DEHB birlikteliğinin olası patofizyolojik mekanizmaları tartışılmaktadır.

References

  • Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and meta regression analysis. Am J Psychiatry. 2007;164:942-8
  • Schweitzer JB, Faber LT, Grafton ST, Tune LE, Hoffman JM, Kilts CD. Alterations in the functional anatomy of working memory in adult attention deficit hyperactivity disorder. Am J Psychiatry. 2000;157:278-80.
  • Jensen PS, Hinshaw SP, Swansom JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn JH, Severe JB, Vitiello B, Wells K, Wigal T. Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): Implications and applications for primary care providers. J Dev Behav Pediatr. 2001;22: 60-73.
  • Sonuga-Barke EJ, Halperin JM. Developmental phenotypes and causal pathways in attention deficit/hyperactivity disorder: potential targets for early intervention? J Child Psychol Psychiatry. 2010;51:368-89.
  • Taylor M, David AS. Agenesis of the corpus callosum: A United Kingdom series of 56 cases. J Neurol Neurosurg Psychiatry. 1998; 64:131-4.
  • Pisani F, Bianchi ME, Scarano A, Viola P, Volante E, Faienza C. Clinical features in subjects with congenital anomalies of the corpus callosum. Acta Biomed Ateneo Parmense. 2000; 71:497-502.
  • Glass HC, Shaw GM, Ma C, Sherr EH. Agenesis of the corpus callosum in California 1983-2003: a population-based study. Am J Med Genet. A. 2008;146:2495-2500.
  • Jeret JS, Serur D, Wisniewski K, Fisch C. Frequency of agenesis of the corpus callosum in the developmentally disabled population as determined by computerized tomography. Pediatr Neurosci. 1985;12:101-3.
  • Frazier JA, Breeze JL, Papadimitriou G, Kennedy DN, Hodge SM, Moore CM, Howard JD, Rohan MP, Caviness VS, Makris N: White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord. 2007;9:799–809.
  • Rueckert L, Levy J. Further evidence that the callosum is involved in sustaining attention. Neuropsychologia. 1996;34:927–35.
  • Barkovich AJ (ed). Pediatric Neuroimaging. Philadelphia: Lippincott Williams&Wilkins, 2000.
  • Giedd JN, Castellanos FX, Casey BJ, Kozuch P, King AC, Hamburger SD, Rapaport JL. Quantitative morphology of the corpus callosum in attention deficit hyperactivity disorder. Am J Psychiatry. 1994; 151:665-69.
  • Prasad AN, Bunzeluk K, Prasad C, Chodirker BN, Magnus KG, Greenberg CR. Agenesis of the corpus callosum and cerebral anomalies in inborn errors of metabolism. Journal of Japanese Teratology Society. 2007; 47:125–35.
  • Hynd GW, Semrud-Clikeman M, Lorys AR, Novey ES, Eliopulos D, Lyytinen H. Corpus callosum morphology in attention deficit-hyperactivity disorder: morphometric analysis of MRI. J Learn Disabil. 1991; 24; 141–6.
  • Lyoo IK, Noam GG, Lee CK, Lee HK, Kennedy BP, Renshaw PF. The corpus callosum and lateral ventricles in children with attention-deficit hyperactivity disorder: a brain magnetic resonance imaging study. Biol Psychiatry. 1996;40; 1060–63.
  • Hutchinson AD, Mathias JL, Banich MT. Corpus callosum morphology in children and adolescents with attention deficit hyperactivity disorder: a metaanalytic review. Neuropsychology. 2008; 22: 341–9.
  • Raybaud C, Girard N. The developmental disorders of the commissural plate of the telencephalon: MR imaging study and morphologic classification. Nerv Syst Child. 1999; 24: 348–57.
  • Symington SH, Paul LK, Symington MF, Ono M, Brown WS Social cognition in individuals with agenesis of the corpus callosum. Soc Neurosci. 2010;5:296-308
  • Yazışma Adresi / Address for Correspondence: Dr. Gonca Çelik Çukurova Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı 01330 Balca lı-ADANA e-mail: goncagulcelik@gmail.com geliş tarihi/received :15.02.2013 kabul tarihi/accepted:29.03.2013
There are 19 citations in total.

Details

Primary Language Turkish
Journal Section Research
Authors

Musa Şahpolat This is me

Gonca Çelik This is me

Ayşe Avcı This is me

Ayşegül Tahiroğlu This is me

Publication Date December 1, 2013
Published in Issue Year 2013 Volume: 38 Issue: 4

Cite

MLA Şahpolat, Musa et al. “Dikkat Eksikliği Hiperaktivite Bozukluğu İle Prezente Olan Corpus Callosum Agenezisi: İki Olgu Bildirimi”. Cukurova Medical Journal, vol. 38, no. 4, 2013, pp. 759-64.