BibTex RIS Cite

Atomoxetine Induced Seperation Anxiety: A Case Report

Year 2013, Volume: 38 Issue: 3, 503 - 505, 01.09.2013

Abstract

Atomoxetine, a selective norepinephrine (NE) inhibitor, is introduced as a safe non-stimulant alternative treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD), especially co-morbid ADHD and anxiety disorder and/or Tourette syndrome. Generally known side effects were including weight loss, decrease appetite, nausea and somnolence, exacerbation of tics. In this paper, we want to present an adolescent case with ADHD-inattention type who developed separation anxiety during Atomoxetine treatment. It will be discussed in light of current knowledge about possible neurotransmitter systems associated with side effects of Atomoxetine. Consequently, atomoxetine treatment may trigger anxiety or obsessional thoughts although without any premorbid psychopathology. However, it is unclear whether effects of genetic, gender or adolescence period are associated with this.

References

  • American Psychiatric Association and American Psychiatric Association Task Force on DSM-IV. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Association. Washington: DC, USA; 2000; S. 943.
  • Spencer TJ, Biederman J, Wilens TE, Faraone SV Overview and neurobiology of attentiondeficit/hyperactivity disorder. J Clin Psychiatry. 2002;63 Suppl 12:3-9.
  • Moran-Gates T, Zhang K, Baldessarini RJ, Tarazi FI Atomoxetine blocks motor hyperactivity in neonatal 6hydroxydopamine-lesioned rats: implications for treatment of attention-deficit hyperactivity disorder. Int J Neuropsychopharmachol 2005; 8: 439-44.
  • Biederman J, Spencer T, Wilens T Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder. Int J Neuropsychopharmacol 2004; 7: 77
  • Michelson D, Allen J, Busner J , Casat C, Dunn D, Kratochvil C et al. Once-daily atomoxetine treatment for children and adolescents with attentiondeficit/hyperactivity disorder: a randomized, placebocontrolled study. Am J Psychiatry 2002; 159: 1896– 0
  • US Food and Drug Administration. Additional safeguards for children on clinical investigation of FDA-regulated products, 21CFR Parts 50 and 56, Federal Register, April 24 2001;66: 20589–600.
  • Sears J, Patel NC Development of Tics in a ThirteenYear-Old Male Following Atomoxetine Use. CNS Spectrum 2008; 13: 301-3.
  • Henderson TA, Hartman K Aggression, mania, and hypomania induction associated with atomoxetine. Pediatrics 2004;114:895-6.
  • Madras BK, Miller GM, Fischman AJ The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry 2005; 57:1397– 09.
  • Bymaster FP, Katner JS, Nelson DL, HemrickLuecke SK, Threlkeld PG, Heiligenstein JH, et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attentiondeficit/hyperactivity disorder. Neuropsychopharmacol 2002; 27:699-711.
  • Arnsten AF, Li BM Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry 2005; 57:1377–84.
  • Yazışma Adresi / Address for Correspondence: Dr. Gonca Gül Çelik Cukurova University School of Medicine Department of Child and Adolescent Psychiatry 01330 Balcalı-ADANA e-mail: goncagulcelik@gmail.com geliş tarihi/received :11.12.2012 kabul tarihi/accepted:28.12.2012

Atomoksetin Tedavisine Bağlı Ayrılma Anksiyetesi: Bir Olgu Sunumu

Year 2013, Volume: 38 Issue: 3, 503 - 505, 01.09.2013

Abstract

Atomoxetine, DEHB, (Dikkat Eksikliği Hiperaktivite Bozukluğu) tedavisinde, özellikle eş tanı olarak anksiyete bozukluğu ve Tourette bozukluğunun olduğu durumlarda uyarıcı olmayan, güvenilir bir alternatif tedavi olarak bilinen seçici norepinefrin geri alım inhibitörüdur. Çoğunlukla bilinen yan etkileri kilo kaybı, iştahta azalma, bulantı, uykuya eğilim ve tiklerde alevlenmedir. Bu yazıda Atomoksetin tedavisi sırasında ayrılma anksiyetesi geliştiren DEHB-dikkat eksikliği tanılı bir ergen olgu sunulacaktır. Güncel bilgiler ışığında Atomoksetine yan etkileri ile ilişkili muhtemel nörotransmitter sistemleri tartışılacaktır. Sonuç olarak Atomokseetin tedavisi premorbid psikopatoloji olmamasına rağmen anksiyeteyi ve obsesyonel düşünceleri tetikleyebilir. Ancak bu reaksiyonun cinsiyet, ergenlik ve genetik etkenlerle ilişkilendirilip ilişkilendirilemeyeceği kesin değildir

References

  • American Psychiatric Association and American Psychiatric Association Task Force on DSM-IV. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Association. Washington: DC, USA; 2000; S. 943.
  • Spencer TJ, Biederman J, Wilens TE, Faraone SV Overview and neurobiology of attentiondeficit/hyperactivity disorder. J Clin Psychiatry. 2002;63 Suppl 12:3-9.
  • Moran-Gates T, Zhang K, Baldessarini RJ, Tarazi FI Atomoxetine blocks motor hyperactivity in neonatal 6hydroxydopamine-lesioned rats: implications for treatment of attention-deficit hyperactivity disorder. Int J Neuropsychopharmachol 2005; 8: 439-44.
  • Biederman J, Spencer T, Wilens T Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder. Int J Neuropsychopharmacol 2004; 7: 77
  • Michelson D, Allen J, Busner J , Casat C, Dunn D, Kratochvil C et al. Once-daily atomoxetine treatment for children and adolescents with attentiondeficit/hyperactivity disorder: a randomized, placebocontrolled study. Am J Psychiatry 2002; 159: 1896– 0
  • US Food and Drug Administration. Additional safeguards for children on clinical investigation of FDA-regulated products, 21CFR Parts 50 and 56, Federal Register, April 24 2001;66: 20589–600.
  • Sears J, Patel NC Development of Tics in a ThirteenYear-Old Male Following Atomoxetine Use. CNS Spectrum 2008; 13: 301-3.
  • Henderson TA, Hartman K Aggression, mania, and hypomania induction associated with atomoxetine. Pediatrics 2004;114:895-6.
  • Madras BK, Miller GM, Fischman AJ The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry 2005; 57:1397– 09.
  • Bymaster FP, Katner JS, Nelson DL, HemrickLuecke SK, Threlkeld PG, Heiligenstein JH, et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attentiondeficit/hyperactivity disorder. Neuropsychopharmacol 2002; 27:699-711.
  • Arnsten AF, Li BM Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry 2005; 57:1377–84.
  • Yazışma Adresi / Address for Correspondence: Dr. Gonca Gül Çelik Cukurova University School of Medicine Department of Child and Adolescent Psychiatry 01330 Balcalı-ADANA e-mail: goncagulcelik@gmail.com geliş tarihi/received :11.12.2012 kabul tarihi/accepted:28.12.2012
There are 12 citations in total.

Details

Primary Language Turkish
Journal Section Research
Authors

Gonca Gül Çelik This is me

Ayşegül Tahiroğlu This is me

Ayşe Avcı This is me

Publication Date September 1, 2013
Published in Issue Year 2013 Volume: 38 Issue: 3

Cite

MLA Çelik, Gonca Gül et al. “Atomoksetin Tedavisine Bağlı Ayrılma Anksiyetesi: Bir Olgu Sunumu”. Cukurova Medical Journal, vol. 38, no. 3, 2013, pp. 503-5.