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Distribution of Postmortem Tissue in Acute Endosulfan Poisoining: Case Report

Year 2013, Volume: 38 Issue: 3, 515 - 519, 01.09.2013

Abstract

In this study, we aimed to determine the distribution of endosulfan in the two postmortem cases, who died due to accidental poisoning. The blood, liver, kidney, brain and stomach content samples obtained from cases were studied with Gas Chromatography-Mass Spectrometry (GC/MS). In the biologic samples, endosulfan isomer (α-Endosulfan and β- Endosulfan) and metabolites (endosulfan sulfate and endosulfan ether) levels were examined. The endosulfan concentrations in the blood were determined as: α- endosulfan was 0.47 mg/l and β-endosulfan was 0.05 mg/l in the first case; α-endofulsan was 0.24 mg/l and β-endosulfan was 0.03 mg/l in the second case. The highest levels of endosulfan were found in the stomach contents. The endosulfan concentrations in the stomach contents were determined as: α-endofulsan was 2.4 mg/kg and β-endosulfan was 1.1 mg/kg in the first case, α- endosulfan was 3.4 mg/kg and β-endosulfan was 2.65 mg/kg in the second case. The liver, brain and the kidney; α- endosulfan, β-endosulfan, endosulfan sulfate and endosulfan ether levels of both cases were examined in our studies as well.

References

  • Klassen CD, Amdur MO, Doull J. Casarett and Doull’s Toxicology: Basic Science of Poisons, 6th Edition, McGraw-Hill International Editions, New York. 2001; 763-84.
  • Vural N. Toksikoloji. Ankara: Ankara Üniversitesi Eczacılık Fakültesi Yayınları. 1996; 342-73..
  • Endosulfan. http://www.inchem.org/documents/pds/pds/pest15_e. htm Yavuz Y, Yürümez Y, Küçüker H, Ela Y, Yüksel S et al. Two cases of acute endosulfan Toxicity . Clinical Toxicology. 2007; 45:530-2.
  • Coronodo-Blanco JL, Repetto M, Ginestal RJ, Vicente JR, Yelamos F, Lardelli A. Acute Intoxication by Endosulfan. Clinical Toxicology. 1992; 30:5755
  • International Atomic Energy Association. IAEAMEL/MESL training manual. No.12, 1998.
  • Frias MM, Torres MJ, Frenich1 AG, Vidal1 JLM, Olea SF, Olea N. Determination of organochlorine compounds in human biological samples by GCMS/MS. Biomedical Chromatography. 2004; 18:102–
  • Lacossie E, Marquet P, Gaulier JM, Dreyfuss MF, Lachatre G. Sensitive and spesific multiresidue methods for the determination of pesticides of various classes in clinical and forensic toxicology. Forensic Science International. 2001; 121: 116-25.
  • Demeter J, Hendrickx. Two lethal endosulfan poisonings in man. Journal of Analytical Toxicology. 1978; 2: 68-74.
  • Coutselinis A, Kentarchou P, Boukis D. Concentration levels of endosulfan in biological material. Forensic Science. 1978; 11:75.
  • Chan MM, Mohd MA. Analysis of Endosulfan and its methabolites in rat plasma and selected tissue samples by gas chromatographymass spectrometry. Environmental Toxicology. 2005; 20:45-52.
  • Ansari RA, Siddiqui MKJ, Gupta PK. Toxicity of endosulfan: distribution of alfa and beta isomers of racemic endosulfan following oral administration in rats. Toxicology Letters. 1984; 21:29-33.
  • Dikshith TSS, Raizada RB, Srivastava MK, Kaphalia BS. Response of rats to repeated oral administration of endosulfan. Industrial Health. 1984;22:295-304.
  • Kuvarega AT, Taru P. Accumulation of Endosulfan in Wild Rat, Rattus norvegious as a Result of Application to Soya Bean in Mazoe (Zimbabwe). Environmental Monitoring and Assessment. 2007; 125:333–45.
  • Chan MPL, Mohd MA. Analysis of Endosulfan and Its Metabolites in Rat Plasma and Selected Tissue Samples by Gas Chromatograph-Mass Spectrometry. Environmental Toxicology. 2005; 20:45-52.
  • Menendez M. Five cases of endosulfan poisoning. Bull Int Assoc Forensic Toxicol. 1988; 20:28-9.
  • Yazışma Adresi / Address for Correspondence: Dr. Nebile Dağlıoğlu Çukurova Üniversitesi Tıp Fakültesi, Adli Tıp Anabilim Dalı 01330 Balcalı-ADANA e-mail: nebiled@hotmail.com geliş tarihi/received :21.12.2012 kabul tarihi/accepted:03.01.2013

Akut Endosülfan Zehirlenmesinde Postmortem Organ Dağılımı : Olgu Sunumu

Year 2013, Volume: 38 Issue: 3, 515 - 519, 01.09.2013

Abstract

Çalışmamızda, kaza sonucu endosülfanla zehirlenen iki ölüm olgusunda endosülfanın vücutta postmortem dağılımının gösterilmesi amaçlanmıştır. Olgulardan alınan kan, karaciğer, böbrek, beyin ve mide içerikleri Gaz Kromatografi-Kütle Spektrometresinde (GC/MS) çalışıldı. Biyolojik örneklerde endosülfan izomer (α-Endosülfan ve β-Endosülfan) ve metabolitlerin (endosülfan sülfat ve endosülfan eter) düzeyleri araştırıldı. Birinci olgunun kanında α-endosülfan 0.47 mg/l, β-endosülfan 0.05 mg/l, ikinci olguda α-endosülfan kanında 0.24 mg/l, β-endosülfan ise 0.03 mg/l olarak bulundu. Endosülfan düzeyinin en yüksek olduğu örneğin mide içeriği olduğu saptandı. Birinci olguda mide içeriğinde α-endosülfan 2.4 mg/kg ve β-endosülfan 1.1 mg/kg, ikinci olguda α-endosülfan 3.4 mg/kg ve β-endosülfan 2.65 mg/kg olarak bulundu. Her iki olgunun karaciğer, beyin ve böbreklerdeki α-endosülfan, β-endosülfan, endosülfan eter ve endosülfan sülfat miktarları da hesaplandı.

References

  • Klassen CD, Amdur MO, Doull J. Casarett and Doull’s Toxicology: Basic Science of Poisons, 6th Edition, McGraw-Hill International Editions, New York. 2001; 763-84.
  • Vural N. Toksikoloji. Ankara: Ankara Üniversitesi Eczacılık Fakültesi Yayınları. 1996; 342-73..
  • Endosulfan. http://www.inchem.org/documents/pds/pds/pest15_e. htm Yavuz Y, Yürümez Y, Küçüker H, Ela Y, Yüksel S et al. Two cases of acute endosulfan Toxicity . Clinical Toxicology. 2007; 45:530-2.
  • Coronodo-Blanco JL, Repetto M, Ginestal RJ, Vicente JR, Yelamos F, Lardelli A. Acute Intoxication by Endosulfan. Clinical Toxicology. 1992; 30:5755
  • International Atomic Energy Association. IAEAMEL/MESL training manual. No.12, 1998.
  • Frias MM, Torres MJ, Frenich1 AG, Vidal1 JLM, Olea SF, Olea N. Determination of organochlorine compounds in human biological samples by GCMS/MS. Biomedical Chromatography. 2004; 18:102–
  • Lacossie E, Marquet P, Gaulier JM, Dreyfuss MF, Lachatre G. Sensitive and spesific multiresidue methods for the determination of pesticides of various classes in clinical and forensic toxicology. Forensic Science International. 2001; 121: 116-25.
  • Demeter J, Hendrickx. Two lethal endosulfan poisonings in man. Journal of Analytical Toxicology. 1978; 2: 68-74.
  • Coutselinis A, Kentarchou P, Boukis D. Concentration levels of endosulfan in biological material. Forensic Science. 1978; 11:75.
  • Chan MM, Mohd MA. Analysis of Endosulfan and its methabolites in rat plasma and selected tissue samples by gas chromatographymass spectrometry. Environmental Toxicology. 2005; 20:45-52.
  • Ansari RA, Siddiqui MKJ, Gupta PK. Toxicity of endosulfan: distribution of alfa and beta isomers of racemic endosulfan following oral administration in rats. Toxicology Letters. 1984; 21:29-33.
  • Dikshith TSS, Raizada RB, Srivastava MK, Kaphalia BS. Response of rats to repeated oral administration of endosulfan. Industrial Health. 1984;22:295-304.
  • Kuvarega AT, Taru P. Accumulation of Endosulfan in Wild Rat, Rattus norvegious as a Result of Application to Soya Bean in Mazoe (Zimbabwe). Environmental Monitoring and Assessment. 2007; 125:333–45.
  • Chan MPL, Mohd MA. Analysis of Endosulfan and Its Metabolites in Rat Plasma and Selected Tissue Samples by Gas Chromatograph-Mass Spectrometry. Environmental Toxicology. 2005; 20:45-52.
  • Menendez M. Five cases of endosulfan poisoning. Bull Int Assoc Forensic Toxicol. 1988; 20:28-9.
  • Yazışma Adresi / Address for Correspondence: Dr. Nebile Dağlıoğlu Çukurova Üniversitesi Tıp Fakültesi, Adli Tıp Anabilim Dalı 01330 Balcalı-ADANA e-mail: nebiled@hotmail.com geliş tarihi/received :21.12.2012 kabul tarihi/accepted:03.01.2013
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Research
Authors

Nebile Dağlıoğlu This is me

Pınar Efeoğlu This is me

Mete K. Gülmen This is me

Necmi Çekin This is me

Publication Date September 1, 2013
Published in Issue Year 2013 Volume: 38 Issue: 3

Cite

MLA Dağlıoğlu, Nebile et al. “Akut Endosülfan Zehirlenmesinde Postmortem Organ Dağılımı : Olgu Sunumu”. Cukurova Medical Journal, vol. 38, no. 3, 2013, pp. 515-9.