Abstract
Watery diarrhea associated with hypokalemia and achlorhydria (WDHA) syndrome is commonly caused by vasoactive intestinal peptide (VIP) secreting tumors in adults and generally associated with neural crest tumors in pediatric population. VIP secretion is associated with neuroblastic cell differentiation. Octreotide treatment can be a choice for diarrhea in such cases. However, its benefit is controversial and surgery is usually needed. A 14-month-old female with diagnosis of inoperable undifferantiated intraabdominal neuroblastoma who developed chronic diarrhea at first year of chemotherapy is reported. Octreotide treatment was used to control diarrhea. Because of the failure of octreotide treatment, debulking surgery was performed and diarrhea subsided after the surgery.
Keywords
References
- Verner JV, Morrison AS. Islet cells tumor and a syndrome of refractory watery diarrhea and hypokalaemia. Am J Med. 1958;25:374–80. Bourdeaut F, de Carli E, Timsit S, et al. VIP hypersecretion as primary or secondary syndrome in neuroblastoma: A retrospective study by the Société Française des Cancers de I’Enfant (SFCE). Pediatr Blood Cancer. 2009; 52:585-90.
Abstract
Diyare ilişkili hipokalemi ve aklorhidri sendromu (WDHA) erişkinlerde çoğunlukla vazoaktif intestinal peptit (VIP) salgılayan tümörlere, çocuklarda ise nöral krest tümörlerine bağlı olarak ortaya çıkmaktadır. VIP salgılanması nöroblastik hücre diferansiyasyonu ile ilişkilidir. Somatostatin analoğu olan ve VIP etkisini antagonize eden oktreotit, bu tür vakalarda diyareye yönelik bir tedavi seçeneği olabilir. Ancak tedavideki yararı tartışmalı olup, hastaların çoğunda diyare cerrahiden sonra geçmektedir. Burada kemoterapisinin 1. yılında kronik diyare gelişen, total kitle rezeksiyonu için uygun olmayan, intraabdominal nöroblastomlu 14 aylık bir kız hastadaki diyare yönetimi sunulmuştur.
Keywords
References
- Verner JV, Morrison AS. Islet cells tumor and a syndrome of refractory watery diarrhea and hypokalaemia. Am J Med. 1958;25:374–80. Bourdeaut F, de Carli E, Timsit S, et al. VIP hypersecretion as primary or secondary syndrome in neuroblastoma: A retrospective study by the Société Française des Cancers de I’Enfant (SFCE). Pediatr Blood Cancer. 2009; 52:585-90.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research |
| Authors | |
| Publication Date | September 1, 2013 |
| Published in Issue | Year 2013 Volume: 38 Issue: 3 |
