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Histopathological analysis of 177 cases with operated intracranial meningioma

Year 2013, Volume: 38 Issue: 1, 41 - 50, 01.03.2013

Abstract

Purpose: Aim of this study is to evaluate histopathologic properties of patients with intracranial meningioma who were operated due to intracranial mass. Method: 177 cases diagnosed with intracranial meningioma were retrospectively examined in our clinic between the years of 2007-2012 and their age, sex, tumor localization, and histopathologic properties were analyzed. Results: 74.6% of 177 intracranial meningioma cases were females, 25.4% were males and the ratio of Male/Female was found 3.4/10. The age interval of the cases was between 12-105 years old. It was most frequently seen at the interval of 51-60. In histopathologic examination, 163 cases (92.1%) were noted as WHO Grade I, 11 cases (6.2%) were WHO Grade II, and 3 cases (1.7%) were WHO Grade III. While meningotelial transitional, and psammomatous type was the most frequently seen in WHO Grade I, atypical meningioma was only dominant in Grade II. In WHO Grade II and III cases, dominance of the male sex was present. While 88.1% of the cases had supratentorial localization, 11.9% had infratentorial localization, 1 case had lateral ventricle localization. In 7 cases (3.9%) of the series, multiple meningiomas were determined. Conclusion: In a series of 177 cases, intracranial meningiomas were seen between 51-60 years old and its most frequent localization was convexity. While Grade I cases were seen in the female sex, dominance of the male sex was present in Grade II and III cases. Additionally, all of multiple meningiomas detected were female cases. Meningotelial meningiomas constitute the most commonly seen subtype among Grade I cases. Key Words: Intracranial meningioma, histopathological classification, clinical study

References

  • Cushing H. The meningiomas (dural endotheliomas): Their source and favored seats of origin: Brain. 1922; 45:282-316.
  • Perry A, Louis DN, Scheithauer BW, Budka H, VonDeimling A: Meningiomas. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds), WHO classification of tumours of the central nervous system, Lyon:IARC Press. 2007; 164–72.
  • Alexiou GA, Markoula S, Gogoy P, Kyritsis AP. Genetic and molecular alterations in meningiomas. ClinNeurolNeurosurg. 2010; 112:261-7
  • Bony AC, Bouvier G, Rue M at al. Brain tumors and hormonal factors: Review of the epidemiological literature. Cancer Causes Control. 2011; 22:697-714 Fisher JL, Schwartzbaum JA, Wrensch MM. Epidemiology of brain tumors. Neurol Clin. 2007; 25:867-90.
  • Korhonen KK, Salminen TT, Raitanen JJ, at al. Female predominance in meningiomas can not be explained by differences in progesterone, estrogen and androgen receptor expression. J Neurooncol. 2006; 80:1-7.
  • Phillips LE, Frankenfeld CL, Drangholt MM, at al. Intracranial meningioma and ionizing radiation in medical and occupational settings. Neurology. 2005; 64:350-2.
  • Haines DE. On thequestion of a subduralspace. Anat Rec 1991; 230:3-21.
  • CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004-2008 (March 23, Revision). Source: Central Brain Tumor Registry of the United States, Hinsdale, IL. 2012. Website: www.cbtrus.org Lawrens E, Dixon M. Meningiomas Imaging. Neurosurgery Volume1 2.nd edition. McGraw-Hill. 1996; 855-72.
  • Borges A. Imaging of the central skull base. Neuroimaging Clinics of North America 2009; 19:669-96.
  • Hakyemez B, Yildirim N, Gokalp G, Erdogan C, Parlak M. The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas. Neuroradiology. 2006; 48:513-20.
  • Nagar VA, Ye JR, Ng WH, Chan YH, Hui F, Lee CK, at al. Diffusion-weighted MR imaging: Diagnosing atypical or malignant meningiomas and detecting tumor dedifferentiation. Am J Neuroradiol 2008; 29:1147-52.
  • Sanverdi SE, Ozgen B, Oguz KK, Mut M, Dolgun A, Soylemezoglu F, at al. Is diffusion-weighted imaging useful in grading and differentiating histopathological subtypes of meningiomas. Eur J Radiol. 2011; Article in press.
  • Berger MS. Perfusion MR and the evaluation of meningiomas: Is it important surgically? AJNR Am J Neuroradiol. 2003; 24:1499-1500.
  • Cho YD, Choi GH, Lee SP, Kim JK. (1)H-MRS metabolic patterns for distinguishing between meningiomas and other brain tumors. Magn Reson Imaging. 2003; 21:663-72.
  • Pfisterer WK, Nieman RA, Scheck AC, Coons SW, Spetzler RF, Preul MC. Using exvivo proton magnetic resonance spectroscopy to reveal associations between biochemical and biological features of meningiomas. Neurosurg Focus. 2010; 28:E
  • Dean BL, Flom RA, Wallace RC, et al. Efficacy of endo-vasculartreatment of meningiomas: Evaluation with matched samples. Am J Neuroradiol. 1994; 15:1675–80.
  • DeMonte F, Marmor E, Al-Mefty O. Meningiomas. Brain Tumors, an encyclopedic approach, 2nd ed ( EdsKaye AH and Laws ER): London, Harcourt Publishers. 2001; 719-51.
  • Bondy M, Ligon BL. Epidemiology and etiology of intracranial meningiomas: A review. J Neurooncol 1996; 29:197–205.
  • Simpson D. Recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 1957; 20:22-39.
  • Commins DL, Atkinson RD, Burnett ME. Review of meningioma histopathology. Neurosurg Focus. 2007; 3:3

177 Opere İntrakranial Meningiom Olgusunun Histopatolojik Özelliklerinin Analizi

Year 2013, Volume: 38 Issue: 1, 41 - 50, 01.03.2013

Abstract

AMAÇ: Kliniğimizde intrakranial kitle nedeniyle opere edilerek meningiom tanısı alan olguların histopatolojik özelliklerinin değerlendirilmesi amaçlandı. MATERYAL VE METOD: 2007-2012 yılları arasında, kliniğimizde intrakranial meningiom tanısı alan 177 olgu retrospektif olarak incelendi ve yaş, cins, tümör lokalizasyonu ve histopatolojik sınıflama özellikleri analiz edildi. BULGULAR: 177 intrakranial meningiom olgusunun % 74.6"sı kadın, % 25.4"ü erkekti ve Erkek/Kadın oranı 3.4/10 olarak bulundu. Olguların yaş aralığı 12-105 arasındaydı. En sık 51-60 yaş aralığında olduğu görüldü. Histopatolojik incelemede; 163 olgu (%92.1) WHO Grade I, 11 olgu (% 6.2) WHO Grade II, 3 olgu (%1.7) ise WHO Grade III olarak tespit edildi. WHO Grade I olgularda sırasıyla meningotelyal, transizyonel ve psammamatöz tip en sık görülürken, Grade II olgularda atipik meningiom hakimiyeti vardı. WHO Grade II ve III olgularda erkek cinsiyet hakimiyeti mevcuttu. Olguların % 88.1"i supratentorial, %11.9"u infratentorial iken, 1 olgu lateral ventrikül yerleşimliydi. Serideki 7 olguda (%3.9) çoğul meningiom saptandı. SONUÇ: 177 olguluk seride intrakranial meningiomların en sık 51-60 yaş arasında görüldüğü ve en sık yerleşim yerinin konveksite olduğu saptandı. Grade I olgular daha sık kadın cinste görülürken, Grade II ve III olgularda erkek hakimiyeti mevcuttu. Ayrıca saptanan çoğul meningiomların hepsi kadın olgulardı. Grade I olgular içinde meningotelyal meningiomlar en fazla görülen alt tipi oluşturmaktaydı.

References

  • Cushing H. The meningiomas (dural endotheliomas): Their source and favored seats of origin: Brain. 1922; 45:282-316.
  • Perry A, Louis DN, Scheithauer BW, Budka H, VonDeimling A: Meningiomas. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds), WHO classification of tumours of the central nervous system, Lyon:IARC Press. 2007; 164–72.
  • Alexiou GA, Markoula S, Gogoy P, Kyritsis AP. Genetic and molecular alterations in meningiomas. ClinNeurolNeurosurg. 2010; 112:261-7
  • Bony AC, Bouvier G, Rue M at al. Brain tumors and hormonal factors: Review of the epidemiological literature. Cancer Causes Control. 2011; 22:697-714 Fisher JL, Schwartzbaum JA, Wrensch MM. Epidemiology of brain tumors. Neurol Clin. 2007; 25:867-90.
  • Korhonen KK, Salminen TT, Raitanen JJ, at al. Female predominance in meningiomas can not be explained by differences in progesterone, estrogen and androgen receptor expression. J Neurooncol. 2006; 80:1-7.
  • Phillips LE, Frankenfeld CL, Drangholt MM, at al. Intracranial meningioma and ionizing radiation in medical and occupational settings. Neurology. 2005; 64:350-2.
  • Haines DE. On thequestion of a subduralspace. Anat Rec 1991; 230:3-21.
  • CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004-2008 (March 23, Revision). Source: Central Brain Tumor Registry of the United States, Hinsdale, IL. 2012. Website: www.cbtrus.org Lawrens E, Dixon M. Meningiomas Imaging. Neurosurgery Volume1 2.nd edition. McGraw-Hill. 1996; 855-72.
  • Borges A. Imaging of the central skull base. Neuroimaging Clinics of North America 2009; 19:669-96.
  • Hakyemez B, Yildirim N, Gokalp G, Erdogan C, Parlak M. The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas. Neuroradiology. 2006; 48:513-20.
  • Nagar VA, Ye JR, Ng WH, Chan YH, Hui F, Lee CK, at al. Diffusion-weighted MR imaging: Diagnosing atypical or malignant meningiomas and detecting tumor dedifferentiation. Am J Neuroradiol 2008; 29:1147-52.
  • Sanverdi SE, Ozgen B, Oguz KK, Mut M, Dolgun A, Soylemezoglu F, at al. Is diffusion-weighted imaging useful in grading and differentiating histopathological subtypes of meningiomas. Eur J Radiol. 2011; Article in press.
  • Berger MS. Perfusion MR and the evaluation of meningiomas: Is it important surgically? AJNR Am J Neuroradiol. 2003; 24:1499-1500.
  • Cho YD, Choi GH, Lee SP, Kim JK. (1)H-MRS metabolic patterns for distinguishing between meningiomas and other brain tumors. Magn Reson Imaging. 2003; 21:663-72.
  • Pfisterer WK, Nieman RA, Scheck AC, Coons SW, Spetzler RF, Preul MC. Using exvivo proton magnetic resonance spectroscopy to reveal associations between biochemical and biological features of meningiomas. Neurosurg Focus. 2010; 28:E
  • Dean BL, Flom RA, Wallace RC, et al. Efficacy of endo-vasculartreatment of meningiomas: Evaluation with matched samples. Am J Neuroradiol. 1994; 15:1675–80.
  • DeMonte F, Marmor E, Al-Mefty O. Meningiomas. Brain Tumors, an encyclopedic approach, 2nd ed ( EdsKaye AH and Laws ER): London, Harcourt Publishers. 2001; 719-51.
  • Bondy M, Ligon BL. Epidemiology and etiology of intracranial meningiomas: A review. J Neurooncol 1996; 29:197–205.
  • Simpson D. Recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 1957; 20:22-39.
  • Commins DL, Atkinson RD, Burnett ME. Review of meningioma histopathology. Neurosurg Focus. 2007; 3:3
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Research
Authors

Güner Menekşe This is me

Yurdal Gezercan This is me

Tuncay Ateş This is me

Kerem Mazhar Özsoy This is me

Ali İhsan Ökten This is me

Pelin Demirtürk This is me

Fulya Adamhasan This is me

Ebru Güzel This is me

Aslan Güzel This is me

Publication Date March 1, 2013
Published in Issue Year 2013 Volume: 38 Issue: 1

Cite

MLA Menekşe, Güner et al. “177 Opere İntrakranial Meningiom Olgusunun Histopatolojik Özelliklerinin Analizi”. Cukurova Medical Journal, vol. 38, no. 1, 2013, pp. 41-50.