Synthesis and Antifungal Activity of New Heterocyclic Compounds

Year 2013, Volume: 38 Issue: 1, 103 - 107, 01.03.2013

Zafer Asım Kaplancıklı Mehlika Dilek Altıntop Gülhan Turan-zitouni Ahmet Özdemir Rasime Demirel Usama Abu Mohsen Weiam Hussein

Abstract

Purpose:The objective of this study was to describe the synthesis of 2-arylthio-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide derivatives as heterocyclic compounds and focused on their potential antifungal effects against fungi species. Method: The reaction of 2-chloro-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide with various aromatic thiols gave 2-arylthio-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide derivatives. Antifungal activities of the synthesized compounds have been evaluated using microbroth dilution method. Results: Four new heterocyclic compounds were synthesized. All compounds were as effective as ketoconazole against T. harzianum, A. ochraceus, C. albicans, whilst the compounds were more effective than ketoconazole against F. solani, F. moniliforme, F. culmorum. Conclusion: All synthesized compounds showed significant antifungal activity when compared with ketoconazole.

Keywords

Antifungal activity, Microbroth dilution method, Dibenzofuran, Heterocyclic compound

Yeni Heterosiklik Bileşiklerin sentezleri ve Antifungal Etkileri

Abstract

Amaç: Bu çalışmanın amacı, heterosiklik bileşik olarak, 2-ariltiyo-N-(2-metoksidibenzo[b,d]furan-3-il)asetamid türevlerinin sentezleri ve mantar türlerine karşı etkilerini araştırmaktır. Yöntem: 2-Kloro-N-(2-metoksidibenzo[b,d]furan-3-il)asetamid ile uygun aromatik tiyollerin reaksiyonu 2-ariltiyo-N-(2-metoksidibenzo[b,d]furan-3-il)asetamid türevlerini verdi. Sentezlenen bu bileşiklerin antifungal aktiviteleri microbroth dilution method kullanılarak araştırıldı. Bulgular: Dört yeni heterosiklik bileşik sentezlendi. Bileşiklerin tamamı F. solani, F. moniliforme, F. culmorum"a karşı Ketokonazol"den daha aktif çıkarken, C. albicans, T. harzianum, A. ochraceus"e karşı Ketokonazol ile aynı etkiyi göstermiştir. Sonuç: Ketokonazol ile kıyaslandığında, sentezlenen tüm bileşikler önemli derecede antifungal etki göstermişlerdir.

Keywords

Antifungal aktivite, Microbroth dilution method, Dibenzofuran, Heterosiklik bileşik

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• ışma Adresi / Address for Correspondence: Dr. Zafer Asım Kaplancıklı Anadolu University Graduate Scholl of Health Sciences ESKİŞEHİR e-mail: [e-mail]. geliş tarihi/received :11.07.2012 kabul tarihi/accepted:07.09.2012