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Diffusion-Weighted Magnetic Resonance Imaging in Renal Lesion Characterization

Year 2012, Volume: 37 Issue: 1, 27 - 36, 01.03.2012

Abstract

Objective: To present the diffusion weighted magnetic resonance imaging findings of the patients with renal lesions and to explore ADC values of cystic and solid lesions. Materials and Methods: 20 patients with renal lesion (16 men, 4 women) were included in the study. All patients evaluated with diffusion weighted magnetic resonance imaging. 9 patients had renal cell carcinoma, one patient had oncocytoma and 10 patients had cyst. Results: Between all ADC values of lesions and ADC values of normal kidney parenchyma were significantly different. In addition, ADC values of malignant lesions were significantly lower than ADC values of normal kidney parenchyma and cyst. The lowest ADC value of malignant lesions was 0.75x 10-3 mm2 / s. The ADC values of malignant lesions varied between 0.75x 10-3 - 2.25x 10-3 mm2 / s values for ADC (b0, 111, 222, 333 s/mm2) . Whereas the lowest ADC value of cysts were calculated 2.81x 10-3 mm2 / s. All cysts had hyperintense signal on T2 weighted and diffusion-weighted images and high ADC values on ADC maps. Malignant lesions had low ADC values on ADC maps. Conclusion: The technique has the advantage that it is non-invasive without need for gadolinium administration, takes about 2 minute. This method provides qualitative and quantitative infomation on tissue characterization. DA-MRI and ADC values are important for characterization of renal lesions. Especially, utility of diffusion-weighted magnetic resonance imaging in the patients with risk for nephrogenic systemic fibrosis (NSF) could be beneficial.

References

  • Le Bihan D, Turner R, Douek P, et al. Diffusion MR Imaging: clinical applications. AJR Am J Roentgenol. 1992; 159:591-9.
  • Srinivasan A, Goyal M, Azri FA, Lum C. State of the art imaging of acute stroke. Radiographics 2006; 26(1) :75-95.
  • Al-Okaili RN, Krejza J, Wang S, Woo JH, Melhem ER. Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults. RadioGraphics 2006; 26(1) :173-189.
  • Yang D, Korogi Y, Sugahara T, et al. Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI. Neuroradiology.2002; 44:656-66
  • Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H. Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent Radiology. 1999; 210:617-23 MR iamging.
  • Yoshikawa T, Kawamitsu H, Mitchell DG, et al. ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol. 2006; 187:1521-30
  • Kim T, Murakami T, Takahashi S, Hori M, Tsuda K,
  • H.Diffusion-weighted Nakamura
  • echoplanar MR imaging for liver disease. AJR Am J
  • Roentgenol. 1999; 173: 393-98 single shot
  • Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T. Diffusion-weighted MR imaging with single shot echo planar imaging in the upper abdomen: preliminary clinical experience in 61 patients. Abdom Imaging. 1999; 24:456-61
  • Thoeny HC, De Keyzer F, Oyen R, Peeters RR. Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases: initial experience. Radiology. 2005; 235:911-17
  • Thoeny HC, Zumstein D, Simon-Zoula S, et al. Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience. Radiology. 2006; 241:812-21.
  • Cova M, Squillaci E, Stacul F, et al. Diffusion- weighted MRI in the evaluation of renal lesions: preliminary results. Br J Radiol. 2004; 77:851-57.
  • Duchene DA, Lotan Y, Cadeddu JA, Sagalowsky AI, Koeneman managed renal tumors: analysis of a contemporary series. Urology. 2003; 62:827-30 of surgically
  • Semelka RC, Shoenut JP, Kroeker MA, Macmahon RG, Greenberg HM. Renal lesions: controlled comparison between CT and 1.5 T MR imaging with nonenhanced suppressed spin-echo and breath-hold FLASH techniques. Radiology. 1992; 182:425-30. fat
  • Scialpi M, Di Maggio A, Midiri M, Loperfido A, Angelelli G, Rotondo A( 2000) Small renal masses: assessment vascularity on dynamic contrast-enhanced MR imaging with fat suppression. AJR Am J Roentgenol. 175:751-57.
  • characterization and
  • Namimoto T, Yamashita Y, Mitsuzaki K, Nakayama Y, Tang Y, Takahashi M. Measurement of the apparent diffusion coefficient in diffuse renal disease by diffusion-weighted echo-planar imaging. J Magn Reson Imaging. 1999; 9:832-7
  • Fukuda Y, Ohashi I, Hanafusa K, Nakagawa T, Ohtani S, Annaka Y, et al. Anisotropic diffusion in kidney: apparent diffusion coefficient measurements for clinical use. J Magn Reson Imaging. 2000; 11: 156-60.
  • Toyoshima S, Noguchi K, Seto H, Shimizu M, Watanabe N. hydronephrosis by diffusion- weighted MR imaging. Acta Radiol. 2000; 41:642-6. evaluation of
  • Chan JHM, Tsui EYK, Luk SH, Fung SL, Cheung YK, Chan MSM, et al. MR diffusion-weighted imaging of kidney: differentiation between hydronephrosis and pyonephrosis. J Clin Imaging. 2001; 25:110-3.
  • Muller MF, Prasad PV, Bimmler D, Kaiser A, Edelman RR. Functional imaging of the kidney by means of measurement of the apparent diffusion coefficient. Radiology. 1994;193:711-5.
  • Koh DM, Collins DJ. Diffusion-weighted MRI in the body: applications and challenges in oncology. AJR Am J Roentgenol. 2007; 188:1622-35.
  • Colagrande S, Carbone SF, Carusi LM, Cova M, Villari N. Magnetic resonance diffusion weighted imaging: extraneurological applications. Radiol Med ( Torino). 2006; 111:392-419.
  • Squillaci E, Manenti G, Di Stefano F, et al. Diffusion- weighted MR imaging in the evaluation of renal tumours. J Exp Clin Cancer Res. 2004; 23:39-45.
  • Zhang J, Tehrani YM, Wang L, et al. Renal masses: characterization with diffusion-weighted MR imaging –a preliminary experience. Radiology. 2008; 247:458-64.
  • Squillaci E, Manenti G, Cova M, Roma M, et al. Correlation of diffusion-weighted MR imaging with cellularity of renal tumours. Anticancer Research. 2004; 24: 4175-80.

Böbrek Lezyonlarının Karakterizasyonunda Difüzyon Ağırlıklı Manyetik Rezonans Görüntülemesi

Year 2012, Volume: 37 Issue: 1, 27 - 36, 01.03.2012

Abstract

Amaç: Böbrek lezyonlarını difüzyon ağırlıklı Manyetik Rezonans Görüntüleme (DA-MRG) ile değerlendirmek ve kistik ve solid lezyonların ADC değerlerini ortaya koymaktır Gereç ve Yöntem: Böbrek lezyonu olan 20 hasta (16 erkek, 4 kadın) çalışmaya dahil edildi. Tüm hastalar (9 renal hücreli karsinom, 1 onkositom, 10 kist) difüzyon ağırlıklı manyetik rezonans görüntüleme ile değerlendirildi Bulgular: Normal böbrek parankiminin ADC değerleri ile lezyonların tüm ADC değerleri arasında istatistiksel olarak önemli fark vardı. Malign lezyonların ADC değerleri normal böbrek parankimi ve kistlerden önemli derecede düşük bulundu. Malign lezyonların en düşük ADC değerleri 0.75x 10-3 mm2 / s bulundu. ADC (b0, 111, 222, 333 s/mm2) için, malign lezyonların ortalama ADC değerleri 0.75x 10-3 - 2.25x 10-3 mm2/s arasında değişmekte olup, buna karşın kistlerin en düşük ADC değerleri 2.81x 10-3 mm2 / s bulundu. Tüm kistler T2 ağırlıklı sekanslarda, difüzyon ağırlıklı görüntülerde hiperintens sinyal ve ADC haritalarında yüksek ADC değerleri gösterirken, malign lezyonlarda düşük ADC değerleri bulundu. Sonuç: DA-MRG’nin avantajı yaklaşık 2 dakika süren, gadolinyum gereksinimi olmayan, noninvaziv bir teknik olmasıdır. Bu metod kalitatif ve kantitatif doku karakterizasyonu yapılmasına olanak sağlamaktadır. Böbrek lezyonlarının karakterizasyonunda difüzyon ağırlıklı görüntüleme ve ADC değerleri önemlidir. Özellikle nefrojenik sistemik fibrozis (NSF) riski olan hastalarda DA-MRG kullanımı yararlı olabilir.

References

  • Le Bihan D, Turner R, Douek P, et al. Diffusion MR Imaging: clinical applications. AJR Am J Roentgenol. 1992; 159:591-9.
  • Srinivasan A, Goyal M, Azri FA, Lum C. State of the art imaging of acute stroke. Radiographics 2006; 26(1) :75-95.
  • Al-Okaili RN, Krejza J, Wang S, Woo JH, Melhem ER. Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults. RadioGraphics 2006; 26(1) :173-189.
  • Yang D, Korogi Y, Sugahara T, et al. Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI. Neuroradiology.2002; 44:656-66
  • Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H. Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent Radiology. 1999; 210:617-23 MR iamging.
  • Yoshikawa T, Kawamitsu H, Mitchell DG, et al. ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol. 2006; 187:1521-30
  • Kim T, Murakami T, Takahashi S, Hori M, Tsuda K,
  • H.Diffusion-weighted Nakamura
  • echoplanar MR imaging for liver disease. AJR Am J
  • Roentgenol. 1999; 173: 393-98 single shot
  • Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T. Diffusion-weighted MR imaging with single shot echo planar imaging in the upper abdomen: preliminary clinical experience in 61 patients. Abdom Imaging. 1999; 24:456-61
  • Thoeny HC, De Keyzer F, Oyen R, Peeters RR. Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases: initial experience. Radiology. 2005; 235:911-17
  • Thoeny HC, Zumstein D, Simon-Zoula S, et al. Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience. Radiology. 2006; 241:812-21.
  • Cova M, Squillaci E, Stacul F, et al. Diffusion- weighted MRI in the evaluation of renal lesions: preliminary results. Br J Radiol. 2004; 77:851-57.
  • Duchene DA, Lotan Y, Cadeddu JA, Sagalowsky AI, Koeneman managed renal tumors: analysis of a contemporary series. Urology. 2003; 62:827-30 of surgically
  • Semelka RC, Shoenut JP, Kroeker MA, Macmahon RG, Greenberg HM. Renal lesions: controlled comparison between CT and 1.5 T MR imaging with nonenhanced suppressed spin-echo and breath-hold FLASH techniques. Radiology. 1992; 182:425-30. fat
  • Scialpi M, Di Maggio A, Midiri M, Loperfido A, Angelelli G, Rotondo A( 2000) Small renal masses: assessment vascularity on dynamic contrast-enhanced MR imaging with fat suppression. AJR Am J Roentgenol. 175:751-57.
  • characterization and
  • Namimoto T, Yamashita Y, Mitsuzaki K, Nakayama Y, Tang Y, Takahashi M. Measurement of the apparent diffusion coefficient in diffuse renal disease by diffusion-weighted echo-planar imaging. J Magn Reson Imaging. 1999; 9:832-7
  • Fukuda Y, Ohashi I, Hanafusa K, Nakagawa T, Ohtani S, Annaka Y, et al. Anisotropic diffusion in kidney: apparent diffusion coefficient measurements for clinical use. J Magn Reson Imaging. 2000; 11: 156-60.
  • Toyoshima S, Noguchi K, Seto H, Shimizu M, Watanabe N. hydronephrosis by diffusion- weighted MR imaging. Acta Radiol. 2000; 41:642-6. evaluation of
  • Chan JHM, Tsui EYK, Luk SH, Fung SL, Cheung YK, Chan MSM, et al. MR diffusion-weighted imaging of kidney: differentiation between hydronephrosis and pyonephrosis. J Clin Imaging. 2001; 25:110-3.
  • Muller MF, Prasad PV, Bimmler D, Kaiser A, Edelman RR. Functional imaging of the kidney by means of measurement of the apparent diffusion coefficient. Radiology. 1994;193:711-5.
  • Koh DM, Collins DJ. Diffusion-weighted MRI in the body: applications and challenges in oncology. AJR Am J Roentgenol. 2007; 188:1622-35.
  • Colagrande S, Carbone SF, Carusi LM, Cova M, Villari N. Magnetic resonance diffusion weighted imaging: extraneurological applications. Radiol Med ( Torino). 2006; 111:392-419.
  • Squillaci E, Manenti G, Di Stefano F, et al. Diffusion- weighted MR imaging in the evaluation of renal tumours. J Exp Clin Cancer Res. 2004; 23:39-45.
  • Zhang J, Tehrani YM, Wang L, et al. Renal masses: characterization with diffusion-weighted MR imaging –a preliminary experience. Radiology. 2008; 247:458-64.
  • Squillaci E, Manenti G, Cova M, Roma M, et al. Correlation of diffusion-weighted MR imaging with cellularity of renal tumours. Anticancer Research. 2004; 24: 4175-80.
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Research
Authors

Elif Karadeli This is me

Gürcan Erbay This is me

Zafer Koç This is me

Bahattin Ulu This is me

Publication Date March 1, 2012
Published in Issue Year 2012 Volume: 37 Issue: 1

Cite

MLA Karadeli, Elif et al. “Böbrek Lezyonlarının Karakterizasyonunda Difüzyon Ağırlıklı Manyetik Rezonans Görüntülemesi”. Cukurova Medical Journal, vol. 37, no. 1, 2012, pp. 27-36.